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HBS1L encodes a member of the GTP-binding elongation factor family. Additionally we are shipping HBS1-Like (S. Cerevisiae) Proteins (3) and many more products for this protein.
Showing 10 out of 74 products:
Human Polyclonal HBS1L Primary Antibody for ICC, IF - ABIN4316620
Ahmad, Boisvert, Lundberg, Uhlen, Lamond: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization. in Molecular & cellular proteomics : MCP 2012
Induction of ribosome rescue factors PELO and HBS1L is required to support protein synthesis when ABCE1 levels fall in platelets, including for hemoglobin production during blood cell development.
Knowledge of the interacting residues in the yeast complexes allowed identification of a splice variant of human HBS1-Like as a Ski7-like exosome-binding protein, revealing the evolutionary conservation of this cytoplasmic cofactor.
high-risk genotypes of six Hb F-associated SNPs, rs9376090, rs7776054, rs9399137, rs9389268, rs9402685 in the HBS1L-MYB (show MYB Antibodies) intergenic region and rs189984760 in the BCL11A (show BCL11A Antibodies) locus, showed association with high Hb F levels
The HBS1L-MYB (show MYB Antibodies) region contains two HbF QTLs, HMIP (show MIPEP Antibodies)-2A and HMIP (show MIPEP Antibodies)-2B (HBS1L-MYB (show MYB Antibodies) intergenic polymorphisms A and B) HMIP (show MIPEP Antibodies)-A is tagged by the SNP rs9399137, with the C" allele promoting HbF. Only 1 sickle cell patient had this allele. HMIP (show MIPEP Antibodies)-B was tagged in these patients by rs4895441and represented Amerindian ethnic origin.
we find that the interaction of UPF2 with UPF3b interferes with the assembly of the UPF2-eRF3 complex, and that UPF2 binds UPF3b more strongly than eRF3
eRF3 neither interacts with the rRNA ribosephosphate backbone nor dissociates from the complex after GTP (show AK3 Antibodies) hydrolysis at translation termination.
The study compares polymorphism at BCL11A (show BCL11A Antibodies) to HBS1L-MYB (show MYB Antibodies) loci and explains less of the variance in HbF in patients with sickle cell disease in Cameroon.
Genetic variants of HBS1L is associated with sickle cell disease.
Several HBS1L-MYB (show MYB Antibodies) intergenic variants reduce transcription factor binding, affecting interactions with MYB (show MYB Antibodies) and MYB (show MYB Antibodies) expression levels. This may explain the genetic association of HBS1L-MYB (show MYB Antibodies) intergenic polymorphisms with erythroid traits and HbF levels.
The non-stop (show USP22 Antibodies) decay mechanism exists in mammalian cells and involves Hbs1, Dom34, and the exosome-Ski (show SKI Antibodies) complex.
This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
HBS1-like (S. cerevisiae)
, HBS1-like protein
, ef-1 alpha
, elongation factor 1-alpha
, ERF3-similar protein
, Hsp70 subfamily B suppressor 1-like protein
, eukaryotic release factor 3