anti-Hes Family bHLH Transcription Factor 1 (HES1) Antibodies

This protein belongs to the basic helix-loop-helix family of transcription factors. Additionally we are shipping HES1 Kits (15) and HES1 Proteins (15) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HES1 3280 Q14469
HES1 15205 P35428
HES1 29577 Q04666
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Top anti-HES1 Antibodies at antibodies-online.com

Showing 10 out of 161 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IF, IP, IHC, WB WB Suggested Anti-HES1 Antibody Titration:  1.25ug/ml  Positive Control:  Raji cell lysate HES1 is strongly supported by BioGPS gene expression data to be expressed in Human Raji cells 100 μL Log in to see 2 to 3 Days
$249.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Hes1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  Rat Kidney 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ChIP, ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: HES-1 Antibody (4H1) [NBP1-47791] - Staining of paraffin-embedded endometrium using anti-Hes1 mouse monoclonal antibody. Immunohistochemistry-Paraffin: HES-1 Antibody (4H1) [NBP1-47791] - Staining of paraffin-embedded Carcinoma of liver using anti-Hes1 mouse monoclonal antibody. 0.1 mL Log in to see 8 to 11 Days
$587.60
Details
Human Rabbit Un-conjugated WB HES1 Antibody (N-term) (ABIN657944) western blot analysis in U251 cell line lysates (35 µg/lane). This demonstrates the HES1 antibody detected the HES1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ICC, IF, IP, WB Western Blot: HES-1 Antibody [NBP1-30912] - PC-12 whole cell extract.12 % SDS-PAGE HES1 antibody [N1], N-term dilution: 1:1000 Western Blot: HES-1 Antibody [NBP1-30912] - Sample(30 ug whole cell lysate)A:A431 12% SDS PAGE, antibody diluted at 1:1000. 100 μL Log in to see 8 to 11 Days
$516.98
Details
Human Mouse Un-conjugated IF, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated FACS, IF, WB Western blot analysis of anti-HES1 Antibody (N-term T24) (ABIN390222) in HL60 cell line lysates (35 µg/lane). HES1 (arrow) was detected using the purified polyclonal antibody (1:60 dilution). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to HES1 on HeLa cell (antibody concentration 10 µg/mL). HES1 monoclonal antibody (M02), clone 3A3. Western Blot analysis of HES1 expression in H9c2(2-1). 100 μg Log in to see 8 to 11 Days
$527.50
Details
Mouse Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human kidney tissue labeled with Anti-HES-1 Polyclonal Antibody, Unconjugated (ABIN682393) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain labeled with Anti-HES1 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$329.45
Details
Bat Rabbit Un-conjugated WB 100 μg Log in to see 11 to 14 Days
$493.17
Details

Top referenced anti-HES1 Antibodies

  1. Cow (Bovine) Polyclonal HES1 Primary Antibody for IF, IP - ABIN2779597 : Hoebeke, De Smedt, Van de Walle, Reynvoet, De Smet, Plum, Leclercq: Overexpression of HES-1 is not sufficient to impose T-cell differentiation on human hematopoietic stem cells. in Blood 2006 (PubMed)
    Show all 12 Pubmed References

  2. Human Monoclonal HES1 Primary Antibody for ChIP, ICC - ABIN4317125 : Wang, Wei, Han, Sato, Ghanbari-Azarnier, Whetstone, Poon, Hu, Zheng, Zhang, Wang, Wunder, Alman: Hedgehog and Notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas. in Cancer research 2012 (PubMed)
    Show all 5 Pubmed References

  3. Human Monoclonal HES1 Primary Antibody for IP, ELISA - ABIN532673 : Iso, Kedes, Hamamori: HES and HERP families: multiple effectors of the Notch signaling pathway. in Journal of cellular physiology 2003 (PubMed)
    Show all 4 Pubmed References

  4. Mouse (Murine) Polyclonal HES1 Primary Antibody for IF (p), IHC (p) - ABIN682393 : Long, Qiu, Liu, Fei, Feng, Wang, Zhong, Yi, Liu, Zhang, Han: Functional recovery and neuronal regeneration of a rat model of epilepsy by transplantation of Hes1-down regulated bone marrow stromal cells. in Neuroscience 2012 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal HES1 Primary Antibody for ELISA, WB - ABIN545784 : Karlsson, Brantsing, Svensson, Brisby, Asp, Tallheden, Lindahl: Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2007 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal HES1 Primary Antibody for ICC, IF - ABIN440957 : Kang, Yang, Xiao, Guo, Guo, Yan, Qi, Wang, Ryffel, Li, Deng: Osteoblast Hypoxia-Inducible Factor-1α Pathway Activation Restrains Osteoclastogenesisviathe Interleukin-33-MicroRNA-34a-Notch1 Pathway. in Frontiers in immunology 1970 (PubMed)

More Antibodies against HES1 Interaction Partners

Human Hes Family bHLH Transcription Factor 1 (HES1) interaction partners

  1. MiR-182 alleviates the development of cyanotic congenital heart disease by suppressing HES1

  2. The results of this study demonstrate that HES1 is a specific downstream gene of NOTCH1 and that it contributes to SACC proliferation, apoptosis and metastasis.

  3. HES1 is mono-ubiquitinated in a Fanconi anemia core complex-dependent manner.

  4. Hes-1 knockdown promotes osteopontin expression in HUVECs and enhances OPN-induced angiogenesis.

  5. Our results suggest that KN promotes goblet cell differentiation by regulating Wnt, Notch, and AhR signals and expression of Hes1 and Hath1.

  6. In the present study, the authors reported the first observation of Hes1 oscillatory expression in human neural progenitor /stem cells, with an approximately 1.5 hour periodicity and a Hes1 protein half-life of about 17 (17.6 +/- 0.2) minutes. Human cytomegalovirus infection disrupts the Hes1 rhythm and down-regulates its expression.

  7. A three-molecule score based on the expression of Notch pathway molecules: Jagged1, intracellular Notch1 (ICN1) and Hes1 (JIH score) to assess prognostic value in non-metastasis clear cell renal cell carcinoma (ccRCC).

  8. we demonstrate for the first time an essential role of HPV oncoprotein E6 that selectively overexpresses in CaCxSLCs and participates in maintenance of stem cell phenotype and stemness through upregulation of Hes1 while preponderance of E7 leads to differentiation.

  9. IE1 is involved in Hes1 degradation by assembling a ubiquitination complex and promoting Hes1 ubiquitination as a potential E3 ubiquitin ligase, followed by proteasomal degradation of Hes1.

  10. Notch signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce neural stem cell maintenance and quiescence in the absence of Notch.

  11. The phenotype was rescued by ectopic expression of miRNA182-5p in Delta182 cells. A bioinformatic analysis and Hes1 modulation data suggested that Hes1 could be a putative target of miRNA182-5p. A reciprocal relationship between miRNA182-5p and Hes1 was seen in the context of TK inhibition

  12. These results suggest that HES1 promotes extracellular matrix protein expression and inhibits proliferative and migratory functions in the trabecular meshwork cells under oxidative stress, thereby providing a novel pathogenic mechanism underlying and a potential therapeutic target to primary open-angle glaucoma

  13. Hes1 disruption leads to tumor regression without perturbing normal stem cell homeostasis, preclinically validating Hes1 as a cancer therapeutic target.

  14. Low Hes1 expression is associated with left ventricle hypertrabeculation/non-compaction and Menetrier-like gastropathy.

  15. GPR146 has an antiviral role in fighting against viral infection, although the GPR146-mediated protection is eliminated by IRF3/HES1-signalling.

  16. In SNSCC, the subgroup of patients with high expression (5th quintile) of HES1 mRNA was associated with better survival (P = .04); however these patients with high expression of HES1 mRNA had also a more favorable tumor stage and grade and more unfavorable resections representing potential confounders.

  17. Loss of nuclear expression of Hes1 occurs in 83% of colorectal adenocarcinomas and is associated with female sex, right-sided location, BRAFV600E mutation, microsatellite instability, larger tumor size, and significantly worse survival.

  18. Hes1 plays a key role in acinar cell integrity and plasticity on cellular insults.

  19. miR-182 reveals its oncogenic capacity in medullary thyroid carcinoma by directly contributing to the invasive behavior through loss of the tumor suppressive HES1/Notch1 signaling circuit.

  20. Cells could therefore regulate the proportion of Wnt- and Notch-mediated control of the Hes1 promoter to coordinate the timing of cell fate selection as they migrate through the intestinal epithelium and are subject to reduced Wnt stimuli. Furthermore, mutant cells characterised by hyperstimulation of the Wnt pathway may, through coupling with Notch, invert cell fate in neighbouring healthy cells, enabling an aberrant cel

Mouse (Murine) Hes Family bHLH Transcription Factor 1 (HES1) interaction partners

  1. this paper shows that epithelial Hes1 maintains gut homeostasis by preventing microbial dysbiosis

  2. miR-374b regulates the proliferation and differentiation of neural stem cells through targeting Hes1. Overexpression of Hes1 reverses the effect of miR-374b overexpression on neural stem cells differentiation.

  3. Hes1 might contribute to the maturation and the cellular structure organization of biliary epithelial cells, which provides new insight into understanding the pathology of biliary atresia.

  4. the results raise the possibility that HES1 or other genes that affect HES1 expression could be involved in the etiology of Ectopic pancreas .

  5. These results suggest that hyperhomocysteinemia-enhanced brain damage is associated with increased autophagy and neuronal apoptosis in Apo E(-/-) mice, in which downregulation of hes1 and hes5 is involved.

  6. Although Hes5-GFP and Hes1 are coexpressed in particular developmental contexts, we also noted cohorts of lens or retinal cells expressing just one factor. The dynamic Hes5-GFP expression pattern, coupled with its derepressed expression in Hes1 mutants, suggests that this transgene contains the relevant cis-regulatory elements that regulate endogenous Hes5 in the mouse lens and retina.

  7. there is a link between Dmrta2 modulation of Hes1 expression and the maintenance of neural progenitor cells during cortical development

  8. Hes-1 expression is maintained in neural progenitor territory throughout mouse neocortical development, a simple shift from Notch-independent to -dependent state makes it pleiotropic as the former maintains the neural stem cells in a non-dividing/slow-dividing state, whereas the latter is very much required for maintenance and proliferation of radial glial cells.

  9. inhibition of PTEN by Notch1/Hes1 in response to high glucose concentration inhibits autophagy, which is associated with the progression of fibrosis in diabetic nephropathy

  10. this paper shows the critical role of the Notch1-Hes1 signaling cascade in the regulation of innate immunity in acetaminophen-triggered liver inflammation

  11. results suggest that SCF(FBXL14) promotes neuronal differentiation by targeting HES1 for ubiquitin-dependent proteolysis and that the C-terminal WRPW motif in HES1 is required for this process

  12. Notch signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce neural stem cell maintenance and quiescence in the absence of Notch.

  13. that HIF-1alpha but not HIF-2alpha is able to interact with either GA-binding protein alpha or GA-binding protein beta1

  14. Hes1 disruption leads to tumor regression without perturbing normal stem cell homeostasis, preclinically validating Hes1 as a cancer therapeutic target.

  15. Notch1-Hes-1 signaling controls TLR7-induced autophagic death of macrophage via regulation of P62 in mice with lupus.

  16. Hes1 plays a key role in acinar cell integrity and plasticity on cellular insults.

  17. the RBPjkappa-dependent Notch targets HES1 and HES5 suppress chondrogenesis and promote the onset of chondrocyte hypertrophy.

  18. this study identifies Hes1 as a homeostatic suppressor of inflammatory responses that exerts its suppressive function by regulating transcription elongation

  19. the glucose-regulated antagonism between CREB and Sirt-1 for Hes-1 transcription participates in the metabolic regulation of neurogenesis.

  20. This study demonstrated that Hes1 and Hes5 modulate not only maintenance of progenitor cells but also pituicyte versus neuron fate specification during neurohypophysis development.

Pig (Porcine) Hes Family bHLH Transcription Factor 1 (HES1) interaction partners

  1. study identified nucleolar complex protein 3 homolog(FAD24) as a novel downstream target of transcription factor HES1 during adipogenesis

HES1 Antigen Profile

Protein Summary

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.

Gene names and symbols associated with HES1

  • hes family bHLH transcription factor 1 (HES1) antibody
  • hairy and enhancer of split 1 (Drosophila) (Hes1) antibody
  • hes family bHLH transcription factor 1 (Hes1) antibody
  • hes family bHLH transcription factor 4 (HES4) antibody
  • hes family bHLH transcription factor 1 L homeolog (hes1.L) antibody
  • bHLHb39 antibody
  • c-hairy1A antibody
  • HAIRY1 antibody
  • HES-1 antibody
  • hes1 antibody
  • HHL antibody
  • Hry antibody
  • Xhairy-1 antibody
  • Xhairy1 antibody
  • Xlh1 antibody

Protein level used designations for HES1

class B basic helix-loop-helix protein 39 , hairy homolog , hairy-like protein , transcription factor HES-1 , RHL , C-HAIRY1 , c-hairy1B , Hairy and enhancer of split 1-A , Protein hairy-1 , hairy1 , transcription factor HES-1-A , hairy and enhancer of split 1 , LOW QUALITY PROTEIN: transcription factor HES-1

GENE ID SPECIES
3280 Homo sapiens
539547 Bos taurus
15205 Mus musculus
29577 Rattus norvegicus
395128 Gallus gallus
100499567 Sus scrofa
397813 Xenopus laevis
100734567 Cavia porcellus
101106560 Ovis aries musimon
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