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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Additionally we are shipping Histone Cluster 1, H3a Kits (1) and Histone Cluster 1, H3a Proteins (1) and many more products for this protein.
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Here, we report that JMJD5, a Jumonji C (JmjC) domain-containing protein, is a Cathepsin L-type protease that mediates histone H3 N-tail proteolytic cleavage under stress conditions that cause a DNA damage response.
Data suggest that Ki-67 (show MKI67 Antibodies) antigen proliferative index has important limitations and hhosphohistone H3 (PHH3) is an alternative proliferative marker.
This data indicates that, in the early developing human brain, HIST1H3B constitutes the largest proportion of H3.1 transcripts among H3.1 isoforms.
This series of 47 diffuse midline gliomas, histone H3 (show HIST3H3 Antibodies)-K27M mutation was mutually exclusive with IDH1 (show IDH1 Antibodies)-R132H mutation and EGFR (show EGFR Antibodies) amplification, rarely co-occurred with BRAF (show BRAF Antibodies)-V600E mutation, and was commonly associated with p53 (show TP53 Antibodies) overexpression, ATRX (show ATRX Antibodies) loss, and monosomy 10. Among these K27M+ diffuse midline gliomas.
Data show that histone chaperone HIRA (show HIRA Antibodies) co-localizes with viral genomes, binds to incoming viral and deposits histone H3.3 (show H3F3A Antibodies) onto these.
These experiments showed that PHF13 (show PHF13 Antibodies) binds specifically to DNA and to two types of histone H3 (show HIST3H3 Antibodies) methyl tags (lysine 4-tri (show VANGL2 Antibodies)-methyl or lysine 4-di-methyl) where it functions as a transcriptional co-regulator.
Hemi-methylated CpGs DNA recognition activates UHRF1 (show UHRF1 Antibodies) ubiquitylation towards multiple lysines on the H3 tail adjacent to the UHRF1 (show UHRF1 Antibodies) histone-binding site.
We describe, for the first time, the MR imaging features of pediatric diffuse midline gliomas with histone H3 (show HIST3H3 Antibodies) K27M mutation
Approximately 30% of pediatric high grade gliomas (pedHGG) including GBM and DIPG harbor a lysine 27 mutation (K27M) in histone 3.3 (H3.3) which is correlated with poor outcome and was shown to influence EZH2 (show EZH2 Antibodies) function.
H3F3A (show H3F3A Antibodies) K27M mutation in adult cerebellar HGG is not rare.
Hemi-methylated DNA opens a closed conformation of UHRF1 (show UHRF1 Antibodies) to facilitate its H3 histone (show HIST1H3B Antibodies) recognition.
Findings show that CCL2 (show CCL2 Antibodies) and CCL3 (show CCL3 Antibodies) are upregulated in the injured peripheral nerve through epigenetic histone modification in infiltrating immune cells such as macrophages.
This result suggests that the incorporation of H3.1 has a detrimental effect on the process of genome remodeling and contributes to the low success rate of somatic nuclear cloning.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails\; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
H3 histone family, member A
, histone 1, H3a
, histone H3.1
, histone H3/a