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The protein encoded by HIPK1 belongs to the Ser/Thr family of protein kinases and HIPK subfamily.
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Mouse (Murine) Monoclonal HIPK1 Primary Antibody for ICC, IF - ABIN2668291
Isono, Nemoto, Li, Takada, Suzuki, Katsuki, Nakagawara, Koseki: Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. in Molecular and cellular biology 2006
Analysis of these mutants revealed that HIPK1, HIPK2 (show HIPK2 Antibodies) and HIPK3 (show HIPK3 Antibodies) but not HIPK4 (show HIPK4 Antibodies) are capable of autophosphorylating on other tyrosines
PAGE4 (show PAGE4 Antibodies), a regulator of c-Jun (show JUN Antibodies) transactivation, is phosphorylated by homeodomain-interacting protein kinase 1.
HIPK1 drives p53 (show TP53 Antibodies) activation to limit colorectal cancer cell growth.
HIPK1 and HIPK2 (show HIPK2 Antibodies), are transcriptional corepressors that regulate TGF-beta (show TGFB1 Antibodies)-dependent angiogenesis during embryonic development.
HIPK1 expression was identified only in invasive breast cancer cells with three different patterns: cytoplasmic, nuclear, and both cytoplasmic and nuclear.
These findings indicate that the control of HIPK1 stability by Mdm2 (show MDM2 Antibodies)-NORE1 (show RASSF5 Antibodies) has a major effect on cell behaviour, and epigenetic inactivation of NORE1 (show RASSF5 Antibodies) enables adenocarcinoma formation in vivo through HIPK1 stabilization.
TNFalpha (show TNF Antibodies)-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha (show TNF Antibodies)-induced ASK1 (show MAP3K5 Antibodies)-JNK (show MAPK8 Antibodies)/p38 (show CRK Antibodies) activation
c-Myb (show MYB Antibodies) appears to be phosphorylated by HIPK1 in its negative regulatory domain as supported by both in vivo and in vitro data.
Therefore, our data confirm that the beta-Catenin (show CTNNB1 Antibodies) signaling plays a dual role in controlling cell proliferation/differentiation in the brain and indicate that Hipk1 is the crucial interactor able to revert the outcome of beta-Catenin (show CTNNB1 Antibodies) signaling in cells.
Despite the expanded marginal zone B cell population in the HIPK1(-/-) mice, the T-independent type 2 humoral response was impaired.
HIPK1 and Daxx (show DAXX Antibodies) collaborate in regulating transcription.
characterization of cells and gene-targeted mice deficient for the p53 (show TP53 Antibodies)-binding kinase homeodomain-interacting protein kinase 1
The present study indicated the overlapping roles for Hipk1 and Hipk2 (show HIPK2 Antibodies) in mediating cell proliferation and apoptosis in response to morphogenetic and genotoxic signals during mouse development.
SENP1 (show SENP1 Antibodies) mediates TNF (show TNF Antibodies)-induced desumoylation and translocation of HIPK1, leading to an enhanced ASK1 (show MAP3K5 Antibodies)-dependent apoptosis.
TNFalpha (show TNF Antibodies)-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha (show TNF Antibodies)-induced ASK1 (show MAP3K5 Antibodies)-JNK (show MAPK8 Antibodies)/p38 (show MAPK14 Antibodies) activation
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
homeodomain interacting protein kinase 1
, homeodomain-interacting protein kinase 1-like
, homeodomain-interacting protein kinase 1
, homeodomain interacting protein kinase 1-like protein
, nuclear body associated kinase 2b
, nuclear body-associated kinase 2
, protein kinase Myak