anti-Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) Antibodies

The protein encoded by HIF3A is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). Additionally we are shipping HIF3A Kits (5) and HIF3A Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HIF3A 64344 Q9Y2N7
HIF3A 53417 Q0VBL6
HIF3A 64345 Q9JHS2
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Top anti-HIF3A Antibodies at antibodies-online.com

Showing 10 out of 88 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-HIF3A Antibody Titration: </b>1.25ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of HIF3 alpha expression in HeLa (A), HepG2 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ICC, IF, IP, WB Western Blot: HIF-3 alpha Antibody [ABIN250965] - Hif3a expression in papillary renal cell carcinoma samples. Image from verified customer review. 0.1 mL Log in to see 7 to 9 Days
$444.19
Details
Human Mouse Un-conjugated IHC, IHC (p), WB Immunohistochemistry: HIF-3 alpha Antibody (2D2) [NBP2-45735] - Analysis of Carcinoma of Human bladder tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Western Blot: HIF-3 alpha Antibody (2D2) [NBP2-45735] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HIF3A. 0.1 mL Log in to see 8 to 11 Days
$585.06
Details
Mouse Rabbit Un-conjugated EIA, IF, IHC (p), WB   0.1 mg Log in to see 12 to 15 Days
$636.30
Details
Human Rabbit Un-conjugated WB Detection of HIF-3 alpha in a reticulocyte lysate using ABIN151687. Western Blot: HIF-3 alpha Antibody [ABIN250675] - Analysis of HIF-3 alpha in Jurkat cell lysate. 0.1 mL Log in to see 7 to 9 Days
$415.44
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Mouse Un-conjugated IHC (p), WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Rat Rabbit Un-conjugated WB Anti-HIF3 antibody, Western blotting WB: Rat Brain Tissue Lysate 100 μg Log in to see 4 to 6 Days
$240.00
Details
Mouse Rabbit Un-conjugated ELISA, WB Western blot using Affinity Purified anti-Hif3A antibody shows detection of a band ~72 kDa corresponding to mouse Hif3A (arrowhead).   Approximately 10 µg of a CoCl<sub>2</sub> treated 3T3 cell lysate (lane 1) and control 3T3 cell lysate (lane 2) were separated by 4-20% SDS-PAGE and transferred onto nitrocellulose.  Treatment of exponentially growing 3T3 cells with 130 µM CoCl<sub>2</sub> for 6 h at 37° C effectively mimics hypoxia.   After blocking the membrane was probed overnight at 4° C with the primary antibody diluted to 1:1,600.  The membrane was washed and reacted with a 1:10,000 dilution of IRDye™800 conjugated Gt-a-Rabbit IgG [H&L] MX (611-132-122) for 45 min at room temperature. IRDye™800 fluorescence image was captured using the Odyssey® Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc.  Other detection systems will yield similar results. Western blot using Affinity Purified anti-Hif antibody shows detection of a band ~72 kDa corresponding to mouse Hif3a (arrowhead). Approximately 10 ?g of a CoCl2 treated 3T3 cell lysate (lane 1) and control 3T3 cell lysate (lane 2) were separated by 4-20% SDS-PAGE and transferred onto nitrocellulose. Treatment of exponentially growing 3T3 cells with 130 uM CoCl2 for 6 h at 37° C effectively mimics hypoxia. After blocking the membrane was probed overnight at 4° C with the primary antibody diluted to 1:1,600. The membrane was washed and reacted with a 1:10,000 dilution of IRDye800 conjugated Gt-a-Rabbit IgG [H&L] MX for 45 min at room temperature. IRDye800 fluorescence image was captured using the Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Other detection systems will yield similar results. 100 μg Log in to see 1 to 2 Days
$389.00
Details

HIF3A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-HIF3A Antibodies

  1. Human Polyclonal HIF3A Primary Antibody for ICC, IF - ABIN250964 : Forooghian, Razavi, Timms: Hypoxia-inducible factor expression in human RPE cells. in The British journal of ophthalmology 2007 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal HIF3A Primary Antibody for ICC, IF - ABIN315681 : Huang, Kapere Ochieng, Kempen, Munck, Swagemakers, van Ijcken, Grosveld, Tibboel, Rottier: Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development. in PLoS ONE 2013 (PubMed)

  3. Human Polyclonal HIF3A Primary Antibody for WB - ABIN151687 : Jackson, Zhang, Hadley, Rabbani, Zhang, Marks, Vujaskovic: Temporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lung. in Free radical biology & medicine 2012 (PubMed)

  4. Human Monoclonal HIF3A Primary Antibody for IHC, IHC (p) - ABIN4317485 : Liu, Fang, Song, Jiang, He, Liu: Expression of hypoxia-inducible factor 3α in hepatocellular carcinoma and its association with other hypoxia-inducible factors. in Experimental and therapeutic medicine 2016 (PubMed)

  5. Human Polyclonal HIF3A Primary Antibody for IHC, WB - ABIN2778530 : Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006 (PubMed)
    Show all 2 Pubmed References

  6. Mouse (Murine) Polyclonal HIF3A Primary Antibody for ELISA, WB - ABIN100475 : Takeda, Ho, Takeda, Duan, Nagy, Fong: Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. in Molecular and cellular biology 2006 (PubMed)

More Antibodies against HIF3A Interaction Partners

Human Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

  1. NAP peptide prevents outer blood retinal barrier breakdown by reducing HIF1alpha (show HIF1A Antibodies)/HIF2alpha (show EPAS1 Antibodies), VEGF (show VEGFA Antibodies)/VEGFRs, and increasing HIF3alpha expression Moreover it is able to reduce the percentage of apoptotic cells by modulating the expression of two death related genes, BAX (show BAX Antibodies) and Bcl2 (show BCL2 Antibodies).

  2. HIF3A methylation was found in the association between the HIF3A rs3826795 polymorphism and alanine aminotransferase (show ALT Antibodies) among obese children.

  3. TIMP2 (show TIMP2 Antibodies) suppression, in a hypoxic environment, was induced through a regulatory feedback circuit consisting of hypoxia-inducible factor (HIF) 1 alpha (show HIF1A Antibodies), microRNA-210 (miR (show MLXIP Antibodies)-210), and HIF-3alpha.

  4. Results were discordant with those expected if HIF3A methylation has a causal effect on body mass index (BMI) & provided more evidence for causality in the reverse direction (i.e., an effect of BMI on HIF3A methylation); results also show a long-lasting intergenerational influence of maternal BMI on offspring methylation at this locus, which may confound associations between own adiposity & HIF3A methylation.

  5. DNA methylation (show HELLS Antibodies) in HIF3A shares moderate correlation between adipose tissue and blood, and both are associated with BMI. In contrast, methylation in FASN (show FASN Antibodies) is poorly correlated across tissues, but the DNA methylation (show HELLS Antibodies) in adipose tissue but not blood is highly associated with BMI

  6. Reduced lifetimes of the donor were partially restored by coexpression of HIF-1alpha (show HIF1A Antibodies) or Bcl-xL (show BCL2L1 Antibodies), binding proteins of IPAS in the nucleus and mitochondria, respectively.

  7. Results confirmed a positive association between BMI and HIF3A DNA promoter methylation in the blood. The tissue-specific results of HIF3A gene expression indicate that subcutaneous adipose tissue is the more functional tissue in which a low expression may adversely affect whole-body insulin (show INS Antibodies) sensitivity.

  8. Parkin (show PARK2 Antibodies) is downregulated under hypoxia and that it interferes with HIF expression based on cellular oxygen tension.

  9. This provides a compelling model for how hypoxia-induced miR (show MLXIP Antibodies)-429 regulates the switch between HIF-1 (show HIF1A Antibodies) adaptive responses to HIF-3 survival responses by rapidly decreasing HIF1A (show HIF1A Antibodies) levels while simultaneously slowing the progression of HIF3A expression until the miR (show MLXIP Antibodies)-429 levels drop below normoxic levels.

  10. The association between increased DNA methylation (show HELLS Antibodies) at HIF3A and increased adiposity is present in neonates.

Mouse (Murine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

  1. Phosphorylation of inhibitory PAS domain protein (IPAS) at Ser184 by MAPK-activated protein kinase 2 (MK2 (show MAPKAPK2 Antibodies) or MAPKAPK2 (show MAPKAPK2 Antibodies)) enhances the proapoptotic function of IPAS.

  2. Report suggests that BV-2 microglial cells express HIF-3a under inflammatory conditions and that its activation differed from that of HIF-1a (show HIF1A Antibodies)

  3. mRNA of HIF-2alpha (show EPAS1 Antibodies) and Ets-1 (show ETS1 Antibodies) were significantly increased by HIF-3alpha ablation. Both factors activate the VE-cadherin (show CDH5 Antibodies) gene, the transcriptional repression of these factors by HIF-3alpha is important for silencing the irrelevant expression of the VE-cadherin (show CDH5 Antibodies) gene.

  4. our data indicated that Tnni2K175del mutation led to abnormally increased hif3a and decreased vegf (show VEGFA Antibodies) in bone, which explain, at least in part, the small body size of Tnni2K175del mice

  5. Anoxia preconditioning increases anti-ischemic neuronal resistance which to a certain extent correlates with the changes of HIF-1alpha (show HIF1A Antibodies) and HIF-3alpha expression.

  6. alternative splicing and expression of IPAS is induced by hypoxia.

  7. By generating mice with a targeted disruption of the NEPAS/HIF-3alpha locus, it was found that homozygous mutant mice, NEPAS/HIF-3alpha(-/-), were viable but displayed enlargement of the right ventricle and impaired lung remodeling.

  8. Identity of third HIF alpha class member, HIF-3alpha. mRNA expression information by mouse MTN. Experimental proof of dimerization with ARNT/HIF-1beta (show ARNT Antibodies).

Zebrafish Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

Cow (Bovine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

HIF3A Antigen Profile

Protein Summary

The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with HIF3A

  • hypoxia inducible factor 3 alpha subunit (HIF3A) antibody
  • hypoxia inducible factor 3, alpha subunit (Hif3a) antibody
  • hypoxia-inducible factor 1, alpha subunit, like (hif1al) antibody
  • bHLHe17 antibody
  • HIF-3A antibody
  • HIF3A antibody
  • Ipas antibody
  • Mop7 antibody
  • NEPAS antibody
  • PASD7 antibody
  • zgc:63965 antibody

Protein level used designations for HIF3A

HIF3-alpha-1 , PAS domain-containing protein 7 , basic-helix-loop-helix-PAS protein MOP7 , class E basic helix-loop-helix protein 17 , hypoxia-inducible factor 3-alpha , inhibitory PAS domain protein , member of PAS protein 7 , HIF-3-alpha , HIF3-alpha , hypoxia inducible factor three alpha , neonatal and embryonic PAS , HIF-3 alpha , HIF3 alpha 1 , hypoxia inducible factor 3 alpha , hypoxia inducible factor 3a , hypoxia-inducible factor 3 alpha , Hif3a , Hif3a-like , hypoxia-inducible factor 3 alpha subunit , hypoxia inducible factor 3, alpha subunit , hypoxia-inducible factor-3 alpha , hypoxia-inducible factor 3-alpha-like

GENE ID SPECIES
64344 Homo sapiens
53417 Mus musculus
64345 Rattus norvegicus
393376 Danio rerio
456149 Pan troglodytes
476429 Canis lupus familiaris
507699 Bos taurus
100135687 Ovis aries
100413902 Callithrix jacchus
100442498 Pongo abelii
100473029 Ailuropoda melanoleuca
100582446 Nomascus leucogenys
100621574 Sus scrofa
100071095 Equus caballus
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