anti-Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) Antibodies

The protein encoded by HIF3A is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). Additionally we are shipping HIF3A Kits (7) and HIF3A Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HIF3A 64344 Q9Y2N7
HIF3A 53417 Q0VBL6
HIF3A 64345 Q9JHS2
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Top anti-HIF3A Antibodies at antibodies-online.com

Showing 10 out of 105 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB WB Suggested Anti-HIF3A Antibody Titration:  1.25ug/ml  Positive Control:  HepG2 cell lysate There is BioGPS gene expression data showing that HIF3A is expressed in HepG2 Human kidney 100 μL Log in to see 2 to 3 Days
$249.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of HIF3 alpha expression in HeLa (A), HepG2 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ICC, IF, IP, WB Western Blot: HIF-3 alpha Antibody [ABIN250965] - Hif3a expression in papillary renal cell carcinoma samples. Image from verified customer review. 0.1 mL Log in to see 7 to 9 Days
$446.35
Details
Human Goat Un-conjugated IHC, ELISA   100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$522.50
Details
Mouse Rabbit Un-conjugated EIA, IF, IHC (p), WB   0.1 mg Log in to see 4 to 8 Days
$632.50
Details
Human Rabbit Un-conjugated WB Detection of HIF-3 alpha in a reticulocyte lysate using ABIN151687. Western Blot: HIF-3 alpha Antibody [ABIN250675] - Analysis of HIF-3 alpha in Jurkat cell lysate. 0.1 mL Log in to see 7 to 9 Days
$418.10
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p), WB Human Lung, Respiratory Epithelium (formalin-fixed, paraffin-embedded) stained with HIF3A antibody ABIN214599 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Placenta (formalin-fixed, paraffin-embedded) stained with HIF3A antibody ABIN214599 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 11 to 14 Days
$550.00
Details

Top referenced anti-HIF3A Antibodies

  1. Human Polyclonal HIF3A Primary Antibody for ICC, IF - ABIN250964 : Forooghian, Razavi, Timms: Hypoxia-inducible factor expression in human RPE cells. in The British journal of ophthalmology 2007 (PubMed)
    Show all 6 Pubmed References

  2. Mouse (Murine) Polyclonal HIF3A Primary Antibody for ELISA, WB - ABIN538410 : Chan, Yao, Gu, Bradfield: Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation. in The Journal of biological chemistry 1999 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal HIF3A Primary Antibody for ICC, IF - ABIN315681 : Huang, Kapere Ochieng, Kempen, Munck, Swagemakers, van Ijcken, Grosveld, Tibboel, Rottier: Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development. in PLoS ONE 2013 (PubMed)

  4. Human Polyclonal HIF3A Primary Antibody for WB - ABIN151687 : Jackson, Zhang, Hadley, Rabbani, Zhang, Marks, Vujaskovic: Temporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lung. in Free radical biology & medicine 2012 (PubMed)

  5. Human Monoclonal HIF3A Primary Antibody for IHC, IHC (p) - ABIN4317485 : Liu, Fang, Song, Jiang, He, Liu: Expression of hypoxia-inducible factor 3α in hepatocellular carcinoma and its association with other hypoxia-inducible factors. in Experimental and therapeutic medicine 2016 (PubMed)

  6. Human Monoclonal HIF3A Primary Antibody for IHC, WB - ABIN2722737 : Cuomo, Coppola, Botti, Maione, Forte, Scisciola, Liguori, Caiafa, Ursini, Galderisi, Cipollaro, Altucci, Cobellis: Pro-inflammatory cytokines activate hypoxia-inducible factor 3α via epigenetic changes in mesenchymal stromal/stem cells. in Scientific reports 2018 (PubMed)

  7. Human Polyclonal HIF3A Primary Antibody for IHC, WB - ABIN2778530 : Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006 (PubMed)
    Show all 2 Pubmed References

  8. Mouse (Murine) Polyclonal HIF3A Primary Antibody for ELISA, WB - ABIN100475 : Takeda, Ho, Takeda, Duan, Nagy, Fong: Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. in Molecular and cellular biology 2006 (PubMed)

More Antibodies against HIF3A Interaction Partners

Human Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

  1. Expression level of HIF3A is downregulated in gestational diabetes patients. The methylation status of HIF3A promoter region is highly correlated with gestational diabetes.

  2. MicroRNA-300 is a tumor suppressor microRNA in non-small cell lung cancer by downregulating HIF3alpha expression.

  3. Under normoxia, HIF-3alpha overexpression promoted pancreatic cancer cell invasion and migration and stimulated F-actin polymerization. In summary, HIF-3alpha promotes pancreatic cancer cell invasion and metastasis in vivo and promotes pancreatic cancer cell invasion and metastasis by transcriptionally activating the RhoC-ROCK1 signaling pathway.

  4. data suggest an important role of miR-210 in sustaining HIF-1alpha activity via the suppression of HIF-3alpha, regulating cell growth and chemotherapeutic drug resistance in cholangiocarcinoma.

  5. AA can protect cardiomyocytes against hypoxia-induced apoptosis through regulating the miR-1290/HIF3A/HIF-1alpha axis, and miR-1290 may be a potential target in the prevention of myocardial ischemia-reperfusion injury

  6. NAP peptide prevents outer blood retinal barrier breakdown by reducing HIF1alpha/HIF2alpha, VEGF/VEGFRs, and increasing HIF3alpha expression Moreover it is able to reduce the percentage of apoptotic cells by modulating the expression of two death related genes, BAX and Bcl2.

  7. HIF3A methylation was found in the association between the HIF3A rs3826795 polymorphism and alanine aminotransferase among obese children.

  8. TIMP2 suppression, in a hypoxic environment, was induced through a regulatory feedback circuit consisting of hypoxia-inducible factor (HIF) 1 alpha, microRNA-210 (miR-210), and HIF-3alpha.

  9. Results were discordant with those expected if HIF3A methylation has a causal effect on body mass index (BMI) & provided more evidence for causality in the reverse direction (i.e., an effect of BMI on HIF3A methylation); results also show a long-lasting intergenerational influence of maternal BMI on offspring methylation at this locus, which may confound associations between own adiposity & HIF3A methylation.

  10. DNA methylation in HIF3A shares moderate correlation between adipose tissue and blood, and both are associated with BMI. In contrast, methylation in FASN is poorly correlated across tissues, but the DNA methylation in adipose tissue but not blood is highly associated with BMI

  11. Reduced lifetimes of the donor were partially restored by coexpression of HIF-1alpha or Bcl-xL, binding proteins of IPAS in the nucleus and mitochondria, respectively.

  12. Results confirmed a positive association between BMI and HIF3A DNA promoter methylation in the blood. The tissue-specific results of HIF3A gene expression indicate that subcutaneous adipose tissue is the more functional tissue in which a low expression may adversely affect whole-body insulin sensitivity.

  13. Parkin is downregulated under hypoxia and that it interferes with HIF expression based on cellular oxygen tension.

  14. miR210 may be a negative regulator of the progression of osteoarthritis, which increases chondrocyte proliferation and prompts extracellular matrix deposition by directly targeting HIF3alpha.

  15. This provides a compelling model for how hypoxia-induced miR-429 regulates the switch between HIF-1 adaptive responses to HIF-3 survival responses by rapidly decreasing HIF1A levels while simultaneously slowing the progression of HIF3A expression until the miR-429 levels drop below normoxic levels.

  16. The association between increased DNA methylation at HIF3A and increased adiposity is present in neonates.

  17. Unsaturated fatty acids are high-affinity ligands of the C-terminal domain from the HIF-3alpha.

  18. HIF3A DNA Methylation Is Associated with Childhood Obesity and ALT

  19. HIF3alpha has a transcriptional regulatory function, which negatively affects gene expression by competing with HIF1alpha and HIF2alpha in binding to transcriptional elements in target genes during hypoxia. (Review)

  20. inverse association with hypertrophic markers in chondrogenic cells

Mouse (Murine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

  1. Phosphorylation of inhibitory PAS domain protein (IPAS) at Ser184 by MAPK-activated protein kinase 2 (MK2 or MAPKAPK2) enhances the proapoptotic function of IPAS.

  2. Report suggests that BV-2 microglial cells express HIF-3a under inflammatory conditions and that its activation differed from that of HIF-1a

  3. mRNA of HIF-2alpha and Ets-1 were significantly increased by HIF-3alpha ablation. Both factors activate the VE-cadherin gene, the transcriptional repression of these factors by HIF-3alpha is important for silencing the irrelevant expression of the VE-cadherin gene.

  4. our data indicated that Tnni2K175del mutation led to abnormally increased hif3a and decreased vegf in bone, which explain, at least in part, the small body size of Tnni2K175del mice

  5. Anoxia preconditioning increases anti-ischemic neuronal resistance which to a certain extent correlates with the changes of HIF-1alpha and HIF-3alpha expression.

  6. It is a negative regulator of tumorigenesis.(review)

  7. alternative splicing and expression of IPAS is induced by hypoxia.

  8. These data suggest an involvement of the HIF system in metabolic derangements as for instance caused by diabetes.

  9. By generating mice with a targeted disruption of the NEPAS/HIF-3alpha locus, it was found that homozygous mutant mice, NEPAS/HIF-3alpha(-/-), were viable but displayed enlargement of the right ventricle and impaired lung remodeling.

  10. Identity of third HIF alpha class member, HIF-3alpha. mRNA expression information by mouse MTN. Experimental proof of dimerization with ARNT/HIF-1beta.

Cow (Bovine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

  1. No significant conclusions could be drawn with respect to susceptibility to other traits. HIF-3alpha could serve as a useful biomarker for donor selection, superovulation improvement, and assisted fertility.

HIF3A Antigen Profile

Protein Summary

The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with HIF3A

  • hypoxia inducible factor 3 alpha subunit (HIF3A) antibody
  • hypoxia inducible factor 3, alpha subunit (Hif3a) antibody
  • bHLHe17 antibody
  • HIF-3A antibody
  • HIF3A antibody
  • Ipas antibody
  • Mop7 antibody
  • NEPAS antibody
  • PASD7 antibody

Protein level used designations for HIF3A

HIF3-alpha-1 , PAS domain-containing protein 7 , basic-helix-loop-helix-PAS protein MOP7 , class E basic helix-loop-helix protein 17 , hypoxia-inducible factor 3-alpha , inhibitory PAS domain protein , member of PAS protein 7 , HIF-3-alpha , HIF3-alpha , hypoxia inducible factor three alpha , neonatal and embryonic PAS , HIF-3 alpha , HIF3 alpha 1 , hypoxia inducible factor 3 alpha , hypoxia inducible factor 3a , hypoxia-inducible factor 3 alpha , hypoxia inducible factor 3, alpha subunit , hypoxia-inducible factor-3 alpha , hypoxia-inducible factor 3-alpha-like

GENE ID SPECIES
64344 Homo sapiens
53417 Mus musculus
64345 Rattus norvegicus
456149 Pan troglodytes
476429 Canis lupus familiaris
507699 Bos taurus
100135687 Ovis aries
100413902 Callithrix jacchus
100442498 Pongo abelii
100473029 Ailuropoda melanoleuca
100582446 Nomascus leucogenys
100621574 Sus scrofa
100071095 Equus caballus
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