anti-IQ Motif and Sec7 Domain 1 (IQSEC1) Antibodies

In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.. Additionally we are shipping IQSEC1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IQSEC1 9922 Q6DN90
IQSEC1 232227 Q8R0S2
IQSEC1 686590  
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Top anti-IQSEC1 Antibodies at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: IQSEC1 Antibody [NBP2-32654] - liver cancer Immunohistochemistry: IQSEC1 Antibody [NBP2-32654] - Immunohistochemical staining of human breast shows strong cytoplasmic and membranous positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: IQSEC1 Antibody [NBP1-81480] Staining of human cell line A-431 shows positivity in nucleoli, vesicles & cell junctions. Immunohistochemistry-Paraffin: IQSEC1 Antibody [NBP1-81480] - Staining of human skin shows strong cytoplasmic positivity in basal cells of squamous epitheium. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB   0.1 mg Log in to see 2 to 3 Days
$360.00
Details
Human Rabbit Un-conjugated IF, IHC (p) Immunofluorescent staining of human cell line A-431 with IQSEC1 polyclonal antibody  at 1-4 ug/mL dilution shows positivity in nucleoli, vesicles and cell junctions. Immunohistochemical staining of human skin with IQSEC1 polyclonal antibody  shows strong cytoplasmic positivity in basal cells of squamous epitheium. 100 μL Log in to see 11 to 12 Days
$577.33
Details
Human Rabbit Un-conjugated ELISA, WB Western Blot of IQSEC1 Antibody Western Blot of Rabbit anti-IQSEC1 antibody. Lane A: A20 cell lysate. Primary antibody: IQSEC1 antibody at 1 µg/mL overnight at 4˚C. Secondary antibody: Goat anti-Rabbit HRP secondary antibody. Block: 5% BLOTTO. Predicted/Observed size: 106 kDa, 103 kDa for IQSEC1.  100 μg Log in to see 1 to 2 Days
$394.90
Details
Human Rabbit Un-conjugated IHC (p) 50 μg Log in to see 12 to 14 Days
$686.14
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB   50 μg Log in to see 12 to 14 Days
$686.14
Details
Human Rabbit Un-conjugated IHC   50 μg Log in to see 11 to 16 Days
$762.14
Details

More Antibodies against IQSEC1 Interaction Partners

Human IQ Motif and Sec7 Domain 1 (IQSEC1) interaction partners

  1. both Arf6 activation through GluN2B-BRAG1 during early development and the transition from BRAG1- to BRAG2-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.

  2. Brag2 is essential for developmental and pathological angiogenesis by promoting endothelial cell sprouting through regulation of adhesion by beta1-integrin internalization and link for the first time the process of beta1-integrin endocytosis with angiogenesis.

  3. The EGFR-GEP100-Arf6 axis affected the prognosis of patients with primary lung adenocarcinoma.

  4. Data show that co-overexpression of GEP100 and AMAP1 (ASAP1) correlates with rapidity of the local recurrence.

  5. GEP100 regulates an Arf6/ERK/uPAR signaling cascade in EGF-induced breast cancer cell invasion.

  6. GEP100 plays a significant role in pancreatic cancer invasion through regulating the expression of E-cadherin and the process of mesenchymal to epithelial transition (MET).

  7. BRAG2 acts at clathrin-coated pits to promote integrin internalization by activating Arf5 and suggest a previously unrecognized role for Arf5 in clathrin-mediated endocytosis of specific cargoes.

  8. GEP100/Arf6 is required for epidermal growth factor-induced ERK/Rac1 signaling and cell migration in human hepatoma HepG2 cells.

  9. The PH domain and the interdomain linker of Brag2 may be targets for selectively regulating the activity of Brag2.

  10. Data suggest that GEP100-Arf6-AMAP1-cortactin pathway, activated by VEGFR2, appears to be common in angiogenesis and cancer invasion and metastasis, and provides their new therapeutic targets.

  11. Cinical study indicates that co-overexpression of Her2 with GEP100 in primary lung adenocarcinomas of patients is correlated with the presence of their node-metastasis with a statistical significance.

  12. a novel phospholipid-regulated antiangiogenic signaling pathway whereby Sema3E activates Arf6 through Plexin-D1 and consequently controls integrin-mediated endothelial cell attachment to the extracellular matrix and migration.

  13. GEP100 functions in phagocytosis via its role in ARF6-dependent actin remodeling.

  14. Arf6 regulates both endocytosis and recycling of beta1 integrins and BRAG2 (IQSEC1) functions selectively to activate Arf6 during integrin internalization

  15. Guanine nucleotide-exchange protein (GEP) 100/BRAG2 has an important role in the activation of ADP-ribosylation factor (ARF)6 for its functions in both E-cadherin recycling and actin remodeling.

  16. Results indicate that GEP100 links EGFR signalling to Arf6 activation to induce invasive activities of some breast cancer cells, and hence may contribute to their metastasis and malignancy.

Mouse (Murine) IQ Motif and Sec7 Domain 1 (IQSEC1) interaction partners

  1. The present study provided evidence that BRAG2a is a novel component of the photoreceptor dystrophin-associated glycoprotein complex (DGC), suggesting functional involvement of the BRAG2a-Arf6 pathway downstream of the DGC.

  2. both Arf6 activation through GluN2B-BRAG1 during early development and the transition from BRAG1- to BRAG2-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.

  3. BRAG2 localized to postsynaptic processes at bipolar dyads, while BRAG3 localized to postsynaptic components at conventional synapses in mouse retina

IQSEC1 Antigen Profile

Protein Summary

In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.

Gene names and symbols associated with IQSEC1

  • IQ motif and Sec7 domain 1 (IQSEC1) antibody
  • IQ motif and Sec7 domain 1 (Iqsec1) antibody
  • ARF-GEP100 antibody
  • ARFGEP100 antibody
  • AW561907 antibody
  • BC026481 antibody
  • BRAG2 antibody
  • cI-43 antibody
  • D6Ertd349e antibody
  • GEP100 antibody
  • mKIAA0763 antibody

Protein level used designations for IQSEC1

ADP-ribosylation factors guanine nucleotide-exchange protein 100 , ADP-ribosylation factors guanine nucleotide-exchange protein 2 , IQ motif and SEC7 domain-containing protein 1 , brefeldin A-resistant ARF-GEF2 , brefeldin-resistant Arf-GEF 2 protein

GENE ID SPECIES
9922 Homo sapiens
232227 Mus musculus
686590 Rattus norvegicus
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