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IRGM encodes a member of the p47 immunity-related GTPase family. Additionally we are shipping Immunity-Related GTPase Family, M Proteins (5) and many more products for this protein.
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Irgm1/IRGM participates in the polarization of M1 macrophages, is upregulated in human atheromata, and promotes development of atheroma in murine experimental atherosclerosis
M1 macrophage may promote Th1 (show HAND1 Antibodies)/Th17 cell differentiation during the early experimental autoimmune encephalomyelitis, and the proinflammatory function of M1 cells requires Irgm1.
A series of metabolic studies indicated that the enhanced cytokine production was associated with marked metabolic changes in the Irgm1-deficient macrophages, including increased glycolysis and an accumulation of long chain acylcarnitines.
data suggested that the deficiency of LRG-47 might affect host's CD4 (show CD4 Antibodies)(+) T cell immune response via the weakening of IFN-gamma (show IFNG Antibodies) downstream signaling
Irgm1-/- embryonic fibroblasts show autophagic flux impairment and defective lysosomal degradation.
Interestingly, we observed that IRGM1 enhanced F-actin polymerization and triggers epithelial mesenchymal transition (EMT) through a mechanism involved in PIK3CA mediated Rac1 activation.
Interferon-beta (show IFNB1 Antibodies) activation recruited the immunity-related GTPase (show RACGAP1 Antibodies) M1 (IRGM1) to the Toxoplasma gondii-occupied parasitophorous vacuole in peritoneal macrophages and murine embryonic fibroblasts.
these data reveal an Irgm1-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1 (show SH3GLB1 Antibodies)-dependent autophagy
Palmitoylation together with the alphaK helix firmly anchor Irgm1 in the Golgi and mitochondria, thus facilitating function of the protein.
2 Irgm1 isoforms generated by differential splicing localize to the Golgi apparatus & weakly to mitochondria. Only the long isoforms is seen on endolysosomal membranes. Irgm1 is a negative regulator of the immunity-related GTPase (show RACGAP1 Antibodies) protein family.
The results confirmed that polymorphisms in NOD2 (show NOD2 Antibodies) (Leu1007insC) and IRGM genes are associated with increased risk of Crohn's disease; whereas the ORMDL3 (show ORMDL3 Antibodies) variant is associated with susceptibility to ulcerative colitis in the Lithuanian early-onset inflammatory bowel disease population.
IRGM rs10065172 was associated with decreased risk of tuberculosis in Asian populations, but not in African/Africa-Americans. rs4958842, rs4859843, and rs4859846, had a large protective effect in Asians, whereas rs72553867 was not associated with tuberculosis risk.
Polymorphisms of IRGM gene is associated with susceptibility to ankylosing spondylitis.
IRGM polymorphism differences between latent and active TB suggests that genetic differences in autophagy might partly affect host TB infection status.
IRGM functional polymorphisms and haplotypes in promoter were associated with the susceptibility to pulmonary tuberculosis in Chinese Hubei Han population.
In Korean children, IRGM rs1000113 and IRGM rs72553867 exhibited associations with early-onset Crohn Disease as risk loci and defense loci, respectively.
The study confirms IRGM rs13361189 and rs4958847 polymorphisms to be important for Crohn's disease susceptibility and phenotype modulation, in accordance with previous findings.
Expression of viral protein 2C enhanced IRGM promoter activation, thereby increasing IRGM expression and inducing autophagy.
these data reveal an Irgm1-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1 (show ZBTB24 Antibodies)-dependent autophagy
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.
immunity-related GTPase family M protein
, immunity-related GTPase M
, immunity-related GTPase family, M
, LPS-stimulated RAW 264.7 macrophage protein 47
, immunity-related GTPase family M protein 1
, interferon inducible protein 1
, interferon-inducible GTPase 3
, interferon-inducible protein 1
, LPS-stimulated RAW 264.7 macrophage protein 47 homolog
, LRG-47-like protein
, immunity-related GTPase family, M1