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anti-Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1) Antibodies

IMPA1 encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second . Additionally we are shipping Inositol(myo)-1(or 4)-Monophosphatase 1 Proteins (18) and Inositol(myo)-1(or 4)-Monophosphatase 1 Kits (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IMPA1 55980  
IMPA1 83523 P97697
IMPA1 3612 P29218
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Top anti-Inositol(myo)-1(or 4)-Monophosphatase 1 Antibodies at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-IMPA1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Human heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using IMPA1 antibody (ABIN5973786) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded rat testis using IMPA1 antibody (ABIN5973786) at dilution of 1/100 (40x lens). 100 μL Log in to see 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using IMPA1 antibody. Immunohistochemistry of paraffin-embedded rat testis using IMPA1 antibody. 200 μL Log in to see 12 to 14 Days
$438.90
Details
Guinea Pig Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using IMPA1 antibody. Immunohistochemistry of paraffin-embedded rat testis using IMPA1 antibody. 100 μL Log in to see 13 to 14 Days
$393.25
Details
Human Mouse Un-conjugated WB Western Blot analysis of IMPA1 expression in transfected 293T cell line by IMPA1 MaxPab polyclonal antibody.Lane 1: IMPA1 transfected lysate(30.47 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (56.58 KDa) . 50 μL Log in to see 11 to 12 Days
$305.71
Details
Human Rabbit Un-conjugated WB IMPA1 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 9 to 11 Days
$473.93
Details
Human Rabbit Un-conjugated ICC, IF, WB Immunocytochemistry/Immunofluorescence: IMPA1 Antibody [NBP2-16964] - Immunofluorescence analysis of methanol-fixed HeLa, using antibody at 1:500 dilution. Western Blot: IMPA1 Antibody [NBP2-16964] - Sample (30 ug of whole cell lysate) A: JurKat B: Raji 12% SDS PAGE gel, diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
$516.98
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using IMPA1 antibody. Immunohistochemistry of paraffin-embedded human liver injury using IMPA1 antibody at dilution of 1:100 (x40 lens). 100 μL Log in to see 16 Days
$366.77
Details

Top referenced anti-Inositol(myo)-1(or 4)-Monophosphatase 1 Antibodies

  1. Human Polyclonal IMPA1 Primary Antibody for ELISA, WB - ABIN561484 : Andreassi, Zimmermann, Mitter, Fusco, De Vita, Devita, Saiardi, Riccio: An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons. in Nature neuroscience 2010 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Inositol(myo)-1(or 4)-Monophosphatase 1 Interaction Partners

Mouse (Murine) Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1) interaction partners

  1. Lithium affects the phosphatidylinositol signaling system in two ways: depleting inositol, consequently decreasing phosphoinositides; elevating inositol monophosphate levels followed by phosphoinositols accumulation. Each or both may mediate lithium-induced behavior

  2. IMPase has a role in intracellular myo-inositol synthesis in craniofacial development and the maintenance of proper brain function

  3. Comparison of MmIMPase 1 and HsIMPase 1 revealed a core r.m.s. deviation of 0.516 A

  4. local synthesis of IMPA1 is required for neurotrophin-dependent axon growth; selective regulation of IMPA1 levels in axons may provide a target for the development of new therapeutic strategies for specific neurological and psychiatric diseases

  5. IMPA1 was expressed in round spermatids

  6. Results suggest that calbindin D28k acts as an activity-dependent sensor that targets membrane/cytoskeleton-bound myo-inositol monophosphatase in central neurons.

  7. IMPA2 has a separate function in vivo from that of IMPA1

  8. IMPA1-/- mouse represents a novel model to study inositol homeostasis, and indicates that genetic inactivation of IMPA1 can mimic some actions of lithium

Human Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1) interaction partners

  1. the high-resolution X-ray structure of human IMPase in complex with L690,330 and manganese ions determined at 1.39 A resolution is reported.

  2. Multibody magnesium cofactor and myo-inositol substrate molecular recognition in the myo-inositol monophosphatase enzyme have been described.

  3. The identification of a novel homozygous duplication of 5 bp in IMPA1, in a large consanguineous family with nine individuals with severe intellectual disability and disruptive behavior.

  4. Comparison of MmIMPase 1 and HsIMPase 1 revealed a core r.m.s. deviation of 0.516 A

  5. The current study did not support a substantial role of the upregulation of IMPase in bipolar disorder, although the lithium-insensitivity trait seen in IMPA2 transgenic mice might represent some aspect relevant to the inositol depletion hypothesis.

  6. No association between polymorphisms and bipolar disorder

  7. IMPA2 has a separate function in vivo from that of IMPA1

Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1) Antigen Profile

Protein Summary

This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Gene names and symbols associated with IMPA1

  • inositol monophosphatase 1 (impa1) antibody
  • inositol(myo)-1(or 4)-monophosphatase 1 (impa1) antibody
  • inositol (myo)-1(or 4)-monophosphatase 1 (Impa1) antibody
  • inositol monophosphatase 1 (Impa1) antibody
  • inositol monophosphatase (impa1) antibody
  • inositol monophosphatase 1 (IMPA1) antibody
  • inositol(myo)-1(or 4)-monophosphatase 1 S homeolog (impa1.S) antibody
  • inositol(myo)-1(or 4)-monophosphatase 1 (IMPA1) antibody
  • 2610002K09Rik antibody
  • 2900059K10Rik antibody
  • AI325909 antibody
  • IMP antibody
  • impa antibody
  • zgc:100926 antibody

Protein level used designations for IMPA1

inositol monophosphatase 1 , Inositol monophosphatase , IMP 1 , IMPase 1 , inositol-1(or 4)-monophosphatase 1 , lithium-sensitive myo-inositol monophosphatase A1 , myo-inositol monophosphatase

GENE ID SPECIES
437018 Danio rerio
100301752 Oncorhynchus mykiss
100380569 Salmo salar
55980 Mus musculus
83523 Rattus norvegicus
397905 Xenopus laevis
3612 Homo sapiens
444552 Xenopus laevis
477925 Canis lupus familiaris
397425 Sus scrofa
281865 Bos taurus
100174641 Pongo abelii
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