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IMPA1 encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second . Additionally we are shipping Inositol(myo)-1(or 4)-Monophosphatase 1 Proteins (18) and Inositol(myo)-1(or 4)-Monophosphatase 1 Kits (9) and many more products for this protein.
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Human Polyclonal IMPA1 Primary Antibody for ELISA, WB - ABIN561484
Andreassi, Zimmermann, Mitter, Fusco, De Vita, Devita, Saiardi, Riccio: An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons. in Nature neuroscience 2010
Show all 2 Pubmed References
Lithium affects the phosphatidylinositol signaling system in two ways: depleting inositol, consequently decreasing phosphoinositides; elevating inositol monophosphate levels followed by phosphoinositols accumulation. Each or both may mediate lithium-induced behavior
IMPase has a role in intracellular myo-inositol synthesis in craniofacial development and the maintenance of proper brain function
Comparison of MmIMPase 1 and HsIMPase 1 revealed a core r.m.s. deviation of 0.516 A
local synthesis of IMPA1 is required for neurotrophin-dependent axon growth; selective regulation of IMPA1 levels in axons may provide a target for the development of new therapeutic strategies for specific neurological and psychiatric diseases
IMPA1 was expressed in round spermatids
Results suggest that calbindin D28k acts as an activity-dependent sensor that targets membrane/cytoskeleton-bound myo-inositol monophosphatase in central neurons.
IMPA2 has a separate function in vivo from that of IMPA1
IMPA1-/- mouse represents a novel model to study inositol homeostasis, and indicates that genetic inactivation of IMPA1 can mimic some actions of lithium
the high-resolution X-ray structure of human IMPase in complex with L690,330 and manganese ions determined at 1.39 A resolution is reported.
Multibody magnesium cofactor and myo-inositol substrate molecular recognition in the myo-inositol monophosphatase enzyme have been described.
The identification of a novel homozygous duplication of 5 bp in IMPA1, in a large consanguineous family with nine individuals with severe intellectual disability and disruptive behavior.
The current study did not support a substantial role of the upregulation of IMPase in bipolar disorder, although the lithium-insensitivity trait seen in IMPA2 transgenic mice might represent some aspect relevant to the inositol depletion hypothesis.
No association between polymorphisms and bipolar disorder
This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
inositol monophosphatase 1
, Inositol monophosphatase
, IMP 1
, IMPase 1
, inositol-1(or 4)-monophosphatase 1
, lithium-sensitive myo-inositol monophosphatase A1
, myo-inositol monophosphatase