anti-Inositol-Trisphosphate 3-Kinase A (ITPKA) Antibodies

Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. Additionally we are shipping ITPKA Proteins (4) and ITPKA Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ITPKA 228550 Q8R071
ITPKA 3706 P23677
ITPKA 81677 P17105
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Top anti-ITPKA Antibodies at antibodies-online.com

Showing 10 out of 68 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc cells, using IP3KA Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, IF, WB 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-ITPKA Antibody (N-term) (ABIN392799) in mouse cerebellum tissue lysates (35 µg/lane). ITPKA(arrow) was detected using the purified polyclonal antibody. 400 μL 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of hITPKA-E360 (ABIN392800) in K562 cell line and mouse lung tissue lysates (35 µg/lane). ITPKA (arrow) was detected using the purified polyclonal antibody. All lanes : Anti-ITPKA Antibody (C-term) at 1:1000 dilution Lane 1: human brain lysate Lane 2: K562 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 51 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:1000 400 μL 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB ABIN6274205 staining HuvEc cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibody. Western blot analysis of extracts from HUVEC cells, using IP3KA antibody.The lane on the left is treated with the antigen-specific peptide. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, IF, WB 200 μL 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of human kidney with ITPKA polyclonal antibody  shows strong membranous and cytoplasmic positivity in tubular cells at 1:200-1:500 dilution. 100 μL 11 to 12 Days
$577.33
Details

Top referenced anti-ITPKA Antibodies

  1. Human Polyclonal ITPKA Primary Antibody for ELISA, WB - ABIN544977 : Mishra, Bhalla: Simulations of inositol phosphate metabolism and its interaction with InsP(3)-mediated calcium release. in Biophysical journal 2002 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal ITPKA Primary Antibody for ELISA - ABIN544978 : Schell, Erneux, Irvine: Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus. in The Journal of biological chemistry 2001 (PubMed)
    Show all 3 Pubmed References

More Antibodies against ITPKA Interaction Partners

Mouse (Murine) Inositol-Trisphosphate 3-Kinase A (ITPKA) interaction partners

  1. Thisstudy shows that overexpressed IP3-kinase A plays a role in some forms of hippocampus-dependent learning and memory tasks as well as in synaptic transmission and plasticity by regulating both presynaptic and postsynaptic functions.

  2. Findings demonstrate that IP3K-A plays an important role in regulating affective states by modulating metabotropic receptor signaling pathways and neural activity in the amygdala.

  3. At synapses of Inositol-1,4,5-trisphosphate 3-kinase-A deficient neurons the levels of Ins(1,4,5)P3-5-phosphatase (inpp5a) and sarcoplasmic/endoplasmic reticulum calcium ATPase pump-2b (serca2b) were increased.

  4. Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.

  5. These data show that the absence of expression of the three isoenzymes of Itpk does not prevent the formation of IP5 and IP6, at least in mouse embryonic fibroblasts.[Itpka, Itpkb, Itpkc]

  6. Inositol 1,4,5-trisphosphate 3-kinase A is critical for spatial and temporal regulation of spine actin remodeling, synaptic plasticity, and learning and memory via an activity-dependent Rac scaffolding mechanism.

Human Inositol-Trisphosphate 3-Kinase A (ITPKA) interaction partners

  1. IP3K-A binds to EB3 and their binding affinity is precisely regulated by protein kinase A (PKA)-dependent phosphorylation of IP3K-A at Ser119 (pSer119). The complex of IP3K-A and EB3 dissociates and reassociates rapidly during chemically induced LTP.

  2. ITPKA is a potential oncogene that it is overexpressed in most tumors, and its overexpression promotes tumorigenesis; ITPKA gene body methylation regulates its expression and serves as a novel and potential biomarker for early cancer detection

  3. Our data indicated that ITPKA expression was significantly up-regulated in hepatocellular carcinoma and could serve as a potential novel prognostic biomarker

  4. describe the crystal structure of the complex between human Ca2+/CaM and the CaM-binding region of human IP3-3K isoform A (residues 158-183)

  5. we conclude that the observed expression of ITPKA early in tumor development increases the metastatic potential of lung adenocarcinoma cells.

  6. Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.

  7. results highlight the potential role of the three isoforms of InsP3 3-kinase as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals

  8. We report the structure of an IPK, the human Ins(1,4,5)P3 3-kinase-A, both free and in complexes with substrates and products.

  9. Data suggest that ITPKA may be related to carcinogenesis by the modulation of inositol polyphosphates and Ca2+ homeostasis and that ITPKA may be a potential novel molecular target and biomarker.

  10. the morphological changes induced by IP3K-A are mediated by non-enzymatic activities of the protein.

ITPKA Antigen Profile

Protein Summary

Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.

Gene names and symbols associated with ITPKA

  • inositol-trisphosphate 3-kinase A-like (LOC564528) antibody
  • Inositol-trisphosphate 3-kinase A (ip3ka) antibody
  • inositol-trisphosphate 3-kinase A (ITPKA) antibody
  • inositol 1,4,5-trisphosphate 3-kinase A (Itpka) antibody
  • inositol-trisphosphate 3-kinase A (Itpka) antibody
  • IP3-3KA antibody
  • IP3KA antibody

Protein level used designations for ITPKA

1D-myo-inositol-trisphosphate 3-kinase A , Inositol-trisphosphate 3-kinase A , IP3 3-kinase A , IP3-kinase A , IP3K A , inositol-trisphosphate 3-kinase A , insP 3-kinase A , inositol 1,4,5-trisphosphate 3-kinase A , inositol 1,4,5-triphosphate 3-kinase , inositol 145-triphosphate 3-kinase

GENE ID SPECIES
564528 Danio rerio
100196437 Salmo salar
100343586 Oryctolagus cuniculus
228550 Mus musculus
3706 Homo sapiens
81677 Rattus norvegicus
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