Insulin Receptor beta (ISR-beta) ELISA Kits

After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Additionally we are shipping Insulin Receptor beta Antibodies (84) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ISR-beta 3643 P06213
ISR-beta 16337 P15208
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Top Insulin Receptor beta ELISA Kits at

Showing 10 out of 20 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Mouse 0.563 ng/mL 0.938-60 ng/mL Diagramm of the ELISA kit to detect Mouse 1 SR-betawith the optical density on the x-axis and the concentration on the y-axis. Typical standard curve 96 Tests 12 to 14 Days
Rat 0.563 ng/mL 0.938-60 ng/mL Typical standard curve 96 Tests 12 to 14 Days
Rabbit 1.0 ng/mL 5.0-100 ng/mL   96 Tests 15 to 18 Days
Guinea Pig 1.0 ng/mL 5.0-100 ng/mL   96 Tests 15 to 18 Days
Human 0.1 ng/mL 1.0-25 ng/mL   96 Tests 15 to 18 Days
Monkey 1.0 ng/mL 5.0-100 ng/mL   96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days
Dog 1.0 ng/mL 5.0-100 ng/mL   96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days

More ELISA Kits for Insulin Receptor beta Interaction Partners

Human Insulin Receptor beta (ISR-beta) interaction partners

  1. Partial lipodystrophy and Type A insulin resistance syndrome due to a novel heterozygous missense mutation in the insulin receptor gene in a mother and daughter pair.

  2. These findings uncover a biased GPCR agonist-induced IR transactivation signaling axis, mediated by Neu1 sialidase and the modification of insulin receptor glycosylation.

  3. insulin binding to the dimeric receptor converts its ectodomain from an inverted U-shaped conformation to a T-shaped conformation.

  4. Modifications of Site 1 of the insulin are sufficient to change the binding to for both insulin receptor and insulin-like growth factor 1 receptor.

  5. the miRNA binding site polymorphism rs1366600 located at the 3'-UTR region of the INSR gene is associated with increased risk of T2DM in Bangladeshi individuals

  6. The role for PGRMC1 maintaining plasma membrane pools of the receptor, modulating IR signaling and function.

  7. Four heterozygous missense mutations within the beta-subunit of insulin receptor (INSR) were detected: Gly1146Arg, Arg1158Trp, Arg1201Trp, and Arg1201Pro mutation in Type A insulin resistance syndrome.

  8. There was a significant upregulation of insulin (INS) and INS Receptor expression levels in Alzheimer's disease both prodromal and fully symptomatic, as compared with controls, but not in mild cognitive impairment subjects.

  9. The structural refinement of the antagonist once conjugated to insulin provided a set of partial agonists exhibiting between 25 and 70% of the maximal agonism of native insulin at the two insulin receptor isoforms, with only slight differences in inherent potency

  10. Cav-2beta isoform yielded by alternative translation initiation desensitizes insulin receptor (IR) via dephosphorylation by PTP1B, and subsequent endocytosis and lysosomal degradation of IR, causing insulin resistance.

  11. They retained the main IGF-1R-related properties, but the hormones with His49 in IGF-1 and His48 in IGF-2 showed significantly higher affinities for IR-A and for IR-B, being the strongest IGF-1- and IGF-2-like binders of these receptors ever reported.

  12. MARCH1 ubiquitinates INSR to decrease cell surface INSR levels, but unlike other INSR ubiquitin ligases, MARCH1 acts in the basal state rather than after insulin stimulation.

  13. single-particle cryo-electron microscopy reconstructions of the 1:2 (4.3 A) and 1:1 (7.4 A) complexes of the insulin receptor ECD dimer with insulin

  14. we aim to provide an overview of the physiological and pathophysiological roles of the IR within metabolic syndrome and its related pathologies, including cardiovascular health, gut microflora composition, gastrointestinal tract functioning, polycystic ovarian syndrome, pancreatic cancer, and neurodegenerative disorders

  15. In vitro results show that glycation of INSR decreases insulin binding under hyperglycemic conditions suggesting this mechanism may provide a mechanism by which INS resistance develops in diabetes.

  16. Circulating pri-miRNA-944 and 3662 can improve non-invasive non-small cell lung cancer detection of operable stages of SCC and AC

  17. current data demonstrate that both INSR and IGF1R are directly targeted by C-myc and exert similar effects to promote the tumorigenesis and metastasis of TSCC through the NF-kappaB pathway.

  18. the mechanism by which insulin induces IR translocation to the cell nucleus, was examined.

  19. We conclude that the crosstalk between angiotensin AT1 receptor and insulin receptor signaling shows a high degree of specificity, and involves Galphaq protein, and activation of distinct kinases. Thus, the BRET(2) technique can be used as a platform for studying molecular mechanisms of crosstalk between insulin receptor and 7TM receptors.

  20. INSR rs1051690 SNP is associated with increased risk of gastric cancer, while polymorphisms in IL12B, CCND1 and IL10 genes are not linked with the presence of gastric cancer

Mouse (Murine) Insulin Receptor beta (ISR-beta) interaction partners

  1. IRA, but not IRB, expression induced increased glucose uptake in the liver and muscle, improving insulin tolerance.

  2. These in vitro data indicate that peripheral insulin must reach the brain parenchyma through alternative pathways rather than crossing the blood-brain barrier via INSR mediated transcytosis.

  3. Insulin and leptin do not exert redundant control of dopamine neuron-mediated modulation of energy balance. Furthermore, neither leptin nor insulin plays a critical role in the modulation of dopamine neurons regarding hedonic feeding behavior or anxiety-related behavior.

  4. These data show that restoration of endothelial insulin receptor expression alone is sufficient to prevent the vascular dysfunction caused by systemically reduced insulin signaling.

  5. Cell-lineage tracing revealed progenitor Leydig cell enrichment is secondary to Insr and Igf1r deletion in differentiated adult Leydig cell , suggesting a feedback mechanism between cells at different steps of differentiation.

  6. Insulin receptor knock-out mice display elevated serum insulin levels, glucose intolerance, and increased insulin content in the islets of Langerhans of the pancreas.

  7. Loss of Endothelial IR Impairs Barrier Function in the Brain.

  8. diabetic gastroparesis was an aggressive process due to the successive damages of myenteric cholinergic neurones and ICC by impairing the insulin/InsR and IGF-1/IGF-1R signaling. Insulin therapy in the early stage may delay diabetic gastroparesis

  9. in beta cells, INSR-B has a protective role, while INSR-A expression sensitizes beta cells to programmed cell death.

  10. we show that glucagon receptor (GCGR) inhibition with a monoclonal antibody normalized blood glucose and beta-hydroxybutyrate levels. Insulin receptor antagonism increased pancreatic beta-cell mass threefold. Normalization of blood glucose levels with GCGR-blocking antibody unexpectedly doubled beta-cell mass relative to that observed with S961 alone and 5.8-fold over control

  11. Data (including data from studies in knockout mice) suggest double knockout (DKO) mice lacking Insr and Igf1r exhibit obesity with insulin resistance and increased adiposity; on high-fat diet, DKO mice exhibit metabolic syndrome. (Insr = insulin receptor; Igf1r = insulin-like growth factor I receptor)

  12. The data in this paper demonstrate that IR knockdown in primary tumors partially reverses the growth-promoting effects of hyperinsulinemia as well as highlighting the importance of the insulin receptor signaling pathway in cancer progression, and more specifically in epithelial-mesenchymal transition.

  13. long-term hepatic expression of IRA could be a promising therapeutic approach for the treatment of type 2 diabetes mellitus.

  14. the overlap of IR and IGF1R signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO-regulated, autophagy-mediated protein degradation

  15. These data reveal a critical pathophysiological role for INSR Thr1160 phosphorylation and provide further mechanistic links between PKCepsilon and INSR in mediating Nonalcoholic fatty liver disease -induced hepatic insulin resistance.

  16. Insr was downregulated in the arcuate nucleus of type 2 diabetic mice.

  17. Mice lacking the insulin receptor in AgRP neurons (AgRP IR KO) exhibited impaired hepatic insulin action because the ability of insulin to suppress hepatic glucose production (hGP) was reduced, but the ability of insulin to suppress lipolysis was unaltered. To the contrary, in POMC IR KO mice, insulin lowered hGP but failed to suppress adipose tissue lipolysis.

  18. Intracellular retention of the insulin receptor is caused by elevated amounts of alpha-taxilin, a free syntaxin binding protein, in HBV expressing hepatocytes preventing proper targeting of the insulin receptor to the cell surface.

  19. Results found that glioblastoma tumors resistant to PDGFR inhibition required the expression and activation of the insulin receptor (IR)/insulin growth-like factor receptor (IGF1R) for tumor cell proliferation and survival.

  20. IR is critical in adipocyte maintenance.

Insulin Receptor beta (ISR-beta) Antigen Profile

Antigen Summary

After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ISR-beta

  • insulin receptor (INSR) antibody
  • insulin receptor (Insr) antibody
  • 4932439J01Rik antibody
  • CD220 antibody
  • D630014A15Rik antibody
  • HHF5 antibody
  • IR antibody
  • IR-A antibody
  • IR-B antibody

Protein level used designations for ISR-beta


3643 Homo sapiens
16337 Mus musculus
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