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Acts as a transcriptional corepressor in a IRF2- dependent manner\; this repression is not mediated by histone deacetylase activities. Additionally we are shipping IRF2BP1 Kits (4) and IRF2BP1 Proteins (3) and many more products for this protein.
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Cow (Bovine) Polyclonal IRF2BP1 Primary Antibody for WB - ABIN610988
Garchon, Djabiri, Viard, Gajdos, Bach: Involvement of human muscle acetylcholine receptor alpha-subunit gene (CHRNA) in susceptibility to myasthenia gravis. in Proceedings of the National Academy of Sciences of the United States of America 1994
Show all 3 Pubmed References
Human Polyclonal IRF2BP1 Primary Antibody for ICC, IF - ABIN4327546
Croner, Stürzl, Rau, Metodieva, Geppert, Naschberger, Lausen, Metodiev: Quantitative proteome profiling of lymph node-positive vs. -negative colorectal carcinomas pinpoints MX1 as a marker for lymph node metastasis. in International journal of cancer 2014
Identification of IRF-2 binding protein 1 and IRF-2 binding protein 2 as co-repressor molecules for interferon regulatory factor-2.
PCTA (IRF2BP1) defines a new component of the TGF-beta signalling pathway that functions to facilitate Smad2 phosphorylation through controlling the accumulation of cPML into the cytoplasm, and consequently, the assembly of Smad2-receptor complex.
IRF2-BP1 is a JDP2-binding protein enhancing the polyubiquitination of JDP2 and represses ATF2-mediated transcriptional activation from a CRE-containing promoter.
Acts as a transcriptional corepressor in a IRF2- dependent manner\; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.
IRF-2-binding protein 1
, interferon regulatory factor 2-binding protein 1
, probable E3 ubiquitin-protein ligase IRF2BP1
, interferon regulatory factor 2-binding protein 1-like
, IRF2 binding protein 1