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Acts as a transcriptional corepressor in a IRF2- dependent manner\; this repression is not mediated by histone deacetylase activities. Additionally we are shipping IRF2BP1 Kits (4) and IRF2BP1 Proteins (3) and many more products for this protein.
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Cow (Bovine) Polyclonal IRF2BP1 Primary Antibody for WB - ABIN610988
Garchon, Djabiri, Viard, Gajdos, Bach: Involvement of human muscle acetylcholine receptor alpha-subunit gene (CHRNA) in susceptibility to myasthenia gravis. in Proceedings of the National Academy of Sciences of the United States of America 1994
Show all 3 Pubmed References
Human Polyclonal IRF2BP1 Primary Antibody for ICC, IF - ABIN4327546
Croner, Stürzl, Rau, Metodieva, Geppert, Naschberger, Lausen, Metodiev: Quantitative proteome profiling of lymph node-positive vs. -negative colorectal carcinomas pinpoints MX1 as a marker for lymph node metastasis. in International journal of cancer 2014
Identification of IRF-2 binding protein 1 and IRF-2 binding protein 2 (show IRF2BP2 Antibodies) as co-repressor molecules for interferon regulatory factor-2 (show IRF2 Antibodies).
PCTA (IRF2BP1) defines a new component of the TGF-beta (show TGFB1 Antibodies) signalling pathway that functions to facilitate Smad2 (show SMAD2 Antibodies) phosphorylation through controlling the accumulation of cPML into the cytoplasm, and consequently, the assembly of Smad2 (show SMAD2 Antibodies)-receptor complex.
IRF2 (show IRF2 Antibodies)-BP1 (show DLX4 Antibodies) is a JDP2 (show JDP2 Antibodies)-binding protein enhancing the polyubiquitination of JDP2 (show JDP2 Antibodies) and represses ATF2 (show ATF2 Antibodies)-mediated transcriptional activation from a CRE-containing promoter.
Acts as a transcriptional corepressor in a IRF2- dependent manner\; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.
IRF-2-binding protein 1
, interferon regulatory factor 2-binding protein 1
, probable E3 ubiquitin-protein ligase IRF2BP1
, interferon regulatory factor 2-binding protein 1-like
, IRF2 binding protein 1