anti-Interferon Regulatory Factor 6 (IRF6) Antibodies

IRF6 encodes a member of the interferon regulatory transcription factor (IRF) family. Additionally we are shipping IRF6 Proteins (9) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IRF6 3664 O14896
IRF6 54139 P97431
IRF6 364081  
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Top anti-IRF6 Antibodies at antibodies-online.com

Showing 10 out of 127 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-IRF6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  Transfected 293T Immunohistochemistry with Placenta tissue at an antibody concentration of 5µg/ml using anti-IRF6 antibody (ARP31995_P050) 100 μL 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  IRF6  Sample Type:  Human Adult Placenta  Antibody Dilution:  1.0ug/ml WB Suggested Anti-IRF6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Transfected 293T 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-IRF6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  293T cell lysate 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-IRF6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Transfected 293T Host:  Rabbit  Target Name:  SERPINA3  Sample Type:  Human Adult Placenta  Antibody Dilution:  1.0ug/ml 100 μL 2 to 3 Days
$319.00
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN184730 staining (0.2µg/ml) of Human Ovary lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-IRF6 Antibody Titration:  2.5ug/ml  Positive Control:  Jurkat cell lysate 100 μL 2 to 3 Days
$229.00
Details
Dog Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with IRF6 antibody ABIN461925 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Human Prostate (formalin-fixed, paraffin-embedded) stained with IRF6 antibody ABIN461925 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IF, WB ICC/IF Image Immunofluorescence analysis of methanol-fixed mouse ESC, using IRF6, antibody at 1:100 dilution. WB Image Western Blot analysis of IRF6 expression in transfected 293T cell line by IRF6 polyclonal antibody. A: Non-transfected lysate. B: IRF6 transfected lysate. 12% SDS PAGE antibody diluted at 1:500 100 μL 3 to 4 Days
$466.18
Details

Top referenced anti-IRF6 Antibodies

  1. Human Polyclonal IRF6 Primary Antibody for ELISA, IHC - ABIN4327608 : Hu, Liu, Li, Ozturk, Gurumurthy, Romano, Sinha, Nawshad: TGFβ3 regulates periderm removal through ΔNp63 in the developing palate. in Journal of cellular physiology 2015 (PubMed)
    Show all 5 Pubmed References

  2. Cow (Bovine) Polyclonal IRF6 Primary Antibody for IHC, WB - ABIN2779406 : Iwata, Suzuki, Pelikan, Ho, Sanchez-Lara, Urata, Dixon, Chai: Smad4-Irf6 genetic interaction and TGF?-mediated IRF6 signaling cascade are crucial for palatal fusion in mice. in Development (Cambridge, England) 2013 (PubMed)

  3. Human Polyclonal IRF6 Primary Antibody for ELISA, WB - ABIN546836 : Kondo, Schutte, Richardson, Bjork, Knight, Watanabe, Howard, de Lima, Daack-Hirsch, Sander, McDonald-McGinn, Zackai, Lammer, Aylsworth, Ardinger, Lidral, Pober, Moreno, Arcos-Burgos, Valencia et al.: Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. ... in Nature genetics 2002 (PubMed)

More Antibodies against IRF6 Interaction Partners

Human Interferon Regulatory Factor 6 (IRF6) interaction partners

  1. IRF6 directly targets the ABCG2 gene and selectively kills cancer stem cells in nasopharyngeal carcinoma

  2. study reports a significant association between the rs2235371 variant in the IRF6 gene and non-syndromic cleft lip/palate in Mexican Mestizos

  3. The association between the missense SNP rs2235371 in gene IRF6 and NSCL/P suggests that this SNP may play an important role as a risk factor for NSCL/P in the Han Chinese populations.

  4. Study demonstrated that ErbB2-driven Irf6 down-regulation in ErbB2-overproducing breast epithelial cells blocks their anoikis and promotes their anchorage-independent growth.

  5. Van de Woude syndrome in a Chinese population was dominantly inherited with high penetrance and variable expressivity. The pathogenic gene was IRF6.

  6. Previously linked to differential expression of IRF6.

  7. We identified a rare mutation in interferon regulatory factor 6 (IRF6) (c.26G>A; p.Arg9Gln) as a candidate of causative mutation. This mutation was predicted to be deleterious. The codon is conserved in many species. The residue change caused by this mutation would affect the structure of IRF6 to a degree. Our study suggested that the rare IRF6 variant is probably the pathogenic mutation in this family.

  8. the cosegregation of an intronic rare variant in NOL4 in one family, and a haplotype consisting of three variants in the noncoding region of IRF6 (introns 1, 8 and 3'UTR) in the other family, are reported.

  9. IRF6 defects are rare in Idiopathic Growth Hormone Deficiency (IGHD) patients.

  10. We detected a significant association between the derived variants, rs2013162 and rs2235371 and the distances between a facial bone plane indicated by distance from Nasion and Point A (NA plane) to soft tissue landmarks; the Subalare (NA-Sbal) and the Subnasale (NA-Sn) in the sagittal plane. IRF6 variants play an important role in the normal range of variation in nasolabial soft-tissue morphology.

  11. The IRF6 rs2235371 T allele decreased the risk of NSCL/P in Chinese Han populations.

  12. We detected a haplotype-based interaction for BMP4 and IRF6 genes for expression of the orofacial cleft phenotype. Although the MDR methods indicate that the effect of interaction between these genes appears to be mild, the presence of specific haplotype combinations conferring a higher risk for NSCL/P reveals the possible combined role of these genes in the pathogenesis of this prevalent birth defect.

  13. IRF6 rs2235375 single nucleotide polymorphism play a major role in the pathogenesis and risk of developing non-syndromic cleft lip with or without palate.

  14. The data suggest that IRF6, TFAP2A, and GRHL3, among others, are shared in neural tube and orofacial development.

  15. The epidermis of children with VWS baring mutations in IRF6 is thicker when compared with the epidermis of children with NSCLP carrying no IRF6 variants. We suggest that this phenotype is a result of increased keratinocyte proliferation in a cell-autonomous fashion. Our data are consistent with a previously described role for IRF6 in epidermal proliferation.

  16. we performed an association study of AXIN2, BMP4 and IRF6 gene SNPs with Non-Syndromic Cleft Lip with or without Cleft Palate in an Iranian population and the findings proposed that BMP4 rs17563 polymorphism is associated with reduced risk against Non-Syndromic Cleft Lip with or without Cleft Palate.

  17. Two novel mutations (Arg31Thr and Trp40Glyfs *23) in the IRF6 gene were identified to be causative for Van der Woude and popliteal pterygium syndromes in 6 Polish families. In the present study no association between the single nucleotide polymorphisms rs7552506, rs2013162, and rs2235375 and the cleft lip and/or palate phenotype was found.

  18. Our results do not support the previously reported association between the A allele of rs642961 and the NSCL phenotype. However, in the VWS/PPS families, the A allele was a risk allele and was, in a large majority (>80%), transmitted on the same chromosome as the IRF6 mutation.

  19. CCL5 and CXCL11 expression were also induced in response to the activation of the PKC pathway, and gene silencing experiments indicated that their inducible expression was dependent on RIPK4 and IRF6. Moreover, gene reporter assays suggested that RIPK4 induces CCL5 and CXCL11 expression by stimulating the transactivation of their promoters by IRF6.

  20. IRF6 is aberrantly silenced by DNA methylation of the 5' IRF6 CGI in melanoma

Zebrafish Interferon Regulatory Factor 6 (IRF6) interaction partners

  1. Here, we demonstrate the protein functions of human IRF6 missense gene variants could be rapidly assessed in detail by their abilities to rescue the irf6 -/- phenotype in zebrafish through variant mRNA microinjections at the one-cell stage.

  2. Fish IRF6 is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 and TBK1, suggesting that differences in the IRF6 regulation pattern exist between lower and higher vertebrates.

  3. Authors report that Kruppel-like factor 17 (Klf17), like Grhl3, acts downstream of Irf6 in this network in zebrafish periderm.

  4. In zebrafish periderm, grainyhead-like 3 (grhl3) (an ancient regulator of the epidermal permeability barrier), was identified as acting downstream of Irf6. Simultaneous inhibition of grhl1 and grhl3 disrupted periderm differentiation in zebrafish.

  5. analysis of zebrafish expression of IRF6

  6. These experiments reveal a conserved role for maternally-encoded Irf6 in differentiation of a simple epithelium in X. laevis and D. rerio.

Mouse (Murine) Interferon Regulatory Factor 6 (IRF6) interaction partners

  1. this study shows that IRF6 and AP2A interaction regulates epidermal development

  2. we observed that deficiencies in Irf6 can lead to mandibular hypoplasia and cleft palate.

  3. we identified IRF6 as a novel PPARgamma co-suppressor that serves a key role in suppressing PPARgamma-mediated cerebrovascular endothelial cytoprotection following ischemia.

  4. IRF6 expression in basal epithelium partially rescues Irf6 knockout mice

  5. Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikkalpha and Irf6.

  6. IRF6 suppresses PPARgamma through binding IRF recognition sites located upstream of the PPARgamma coding region. Taken together, the results suggest that an IRF6/PPARgamma regulatory axis suppresses anti-inflammatory responses in bone marrow-derived macrophages and provides references for future study addressing dysregulated metabolic and immunologic homeostasis of obese adipose tissue.

  7. Irf6 and RTK signaling interact in regulating periderm differentiation and function, as well as provide a rationale to screen for epistatic interactions between variants in IRF6 and RTK signaling pathway genes in human orofacial clefting populations.

  8. These data provide the first mechanistic insight into the heightened caries susceptibility associated with CLP and indicate a direct role for the major CLP gene Irf6 in salivary gland development and a significant role in regulating oral immunity in mice.

  9. role in tooth number, crown and root morphology and amelogenesis

  10. that downregulation of interferon regulatory factor 6 affords protection against TNI through Akt-eNOS pathway-mediated antioxidative and anti-inflammatory activity

  11. Irf6 is required for resistance to Lipopolysaccharides-induced endotoxic shock. In addition, Irf6-deficient bone marrow-derived neutrophils exhibited increased chemotactic index and velocity compared with wild-type cells in vitro.

  12. TGFbeta3 increases IRF6 expression and subsequently regulates SNAI2 expression; IRF6 appears to regulate epithelial mesenchymal transition during palatal fusion via SNAI2.

  13. Pvrl1 is a bona fide target gene of the transcription factor p63, whereas Pvrl4 regulation is linked to epidermal differentiation and is under Irf6

  14. Data suggest that Irf6 functions through the RhoA pathway to regulate cellular migration.

  15. These results support a role for IRF6 in brain morphometry and provide evidence for a potential genetic link to abnormal brain development in orofacial clefting.

  16. Irf6 plays important cell-autonomous and non-cell-autonomous roles in muscular differentiation and cytoskeletal formation in the tongue.

  17. Irf6 plays a critical role in regulating epithelial invagination

  18. IRF6 and SMAD4 synergistically regulate the fate of the medial edge epithelium (MEE), and TGFbeta-mediated Irf6 activity is responsible for MEE degeneration during palatal fusion in mice.

  19. Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.

  20. These data suggest that MCS9.7 enhancer activity is not sufficient to recapitulate IRF6 expression, and that p63 expression is not always necessary nor sufficient for transactivation of IRF6.

IRF6 Antigen Profile

Protein Summary

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with IRF6

  • interferon regulatory factor 6 (IRF6) antibody
  • interferon regulatory factor 6 (irf6) antibody
  • interferon regulatory factor 6 S homeolog (irf6.S) antibody
  • interferon regulatory factor 6 (Irf6) antibody
  • AI876454 antibody
  • DKFZp469E012 antibody
  • E230028I05Rik antibody
  • IRF6 antibody
  • LPS antibody
  • mirf6 antibody
  • OFC6 antibody
  • PIT antibody
  • PPS antibody
  • PPS1 antibody
  • VWS antibody
  • VWS1 antibody
  • xIRF-6 antibody
  • zgc:63500 antibody

Protein level used designations for IRF6

interferon regulatory factor 6 , interferon regulatory factor 6-like , IRF-6

GENE ID SPECIES
443083 Ovis aries
457701 Pan troglodytes
594908 Xenopus (Silurana) tropicalis
712958 Macaca mulatta
100174467 Pongo abelii
100402804 Callithrix jacchus
100594750 Nomascus leucogenys
3664 Homo sapiens
393570 Danio rerio
443771 Xenopus laevis
480015 Canis lupus familiaris
397521 Sus scrofa
614253 Bos taurus
54139 Mus musculus
364081 Rattus norvegicus
100349520 Oryctolagus cuniculus
419863 Gallus gallus
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