anti-Interferon Regulatory Factor 6 (IRF6) Antibodies

IRF6 encodes a member of the interferon regulatory transcription factor (IRF) family.

list all antibodies Gene Name GeneID UniProt
Anti-Human IRF6 IRF6 3664 O14896
Anti-Mouse IRF6 IRF6 54139 P97431
Anti-Rat IRF6 IRF6 364081  
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Top anti-IRF6 Antibodies at antibodies-online.com

Showing 10 out of 109 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-IRF6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  Transfected 293T Immunohistochemistry with Placenta tissue at an antibody concentration of 5µg/ml using anti-IRF6 antibody (ARP31995_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-IRF6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  293T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-IRF6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Transfected 293T Host:  Rabbit  Target Name:  SERPINA3  Sample Type:  Human Adult Placenta  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  IRF6  Sample Type:  Human Adult Placenta  Antibody Dilution:  1.0ug/ml WB Suggested Anti-IRF6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Transfected 293T 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-IRF6 Antibody Titration:  2.5ug/ml  Positive Control:  Jurkat cell lysate WB Suggested Anti-IRF6 <br /> Antibody Titration: 2.5 µg/mL <br /> Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Dog Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$522.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN184730 staining (0.2µg/ml) of Human Ovary lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB Immunohistochemistry-Paraffin: IRF6 Antibody [NBP1-51911] - staining. Western Blot: IRF6 Antibody [NBP1-51911] - Western blot analysis of IRF6 in Human Ovary lysate using NBP1-51911 at 0.2 ug/ ml. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with IRF6 antibody ABIN461925 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Human Prostate (formalin-fixed, paraffin-embedded) stained with IRF6 antibody ABIN461925 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$484.00
Details

Top referenced anti-IRF6 Antibodies

  1. Human Polyclonal IRF6 Primary Antibody for ELISA, IHC - ABIN4327608 : Hu, Liu, Li, Ozturk, Gurumurthy, Romano, Sinha, Nawshad: TGFβ3 regulates periderm removal through ΔNp63 in the developing palate. in Journal of cellular physiology 2015 (PubMed)
    Show all 5 Pubmed References

  2. Cow (Bovine) Polyclonal IRF6 Primary Antibody for IHC, WB - ABIN2779406 : Iwata, Suzuki, Pelikan, Ho, Sanchez-Lara, Urata, Dixon, Chai: Smad4-Irf6 genetic interaction and TGF?-mediated IRF6 signaling cascade are crucial for palatal fusion in mice. in Development (Cambridge, England) 2013 (PubMed)

More Antibodies against IRF6 Interaction Partners

Human Interferon Regulatory Factor 6 (IRF6) interaction partners

  1. The data suggest that IRF6, TFAP2A (show TFAP2A Antibodies), and GRHL3 (show GRHL3 Antibodies), among others, are shared in neural tube and orofacial development.

  2. The epidermis of children with VWS baring mutations in IRF6 is thicker when compared with the epidermis of children with NSCLP carrying no IRF6 variants. We suggest that this phenotype is a result of increased keratinocyte proliferation in a cell-autonomous fashion. Our data are consistent with a previously described role for IRF6 in epidermal proliferation.

  3. we performed an association study of AXIN2 (show AXIN2 Antibodies), BMP4 (show BMP4 Antibodies) and IRF6 gene SNPs with Non-Syndromic Cleft Lip with or without Cleft Palate in an Iranian population and the findings proposed that BMP4 (show BMP4 Antibodies) rs17563 polymorphism is associated with reduced risk against Non-Syndromic Cleft Lip with or without Cleft Palate.

  4. Two novel mutations (Arg31Thr and Trp40Glyfs *23) in the IRF6 gene were identified to be causative for Van (show TNIP1 Antibodies) der (show GDF3 Antibodies) Woude and popliteal pterygium syndromes in 6 Polish families. In the present study no association between the single nucleotide polymorphisms rs7552506, rs2013162, and rs2235375 and the cleft lip and/or palate phenotype was found.

  5. Our results do not support the previously reported association between the A allele of rs642961 and the NSCL (show NHLH1 Antibodies) phenotype. However, in the VWS/PPS families, the A allele was a risk allele and was, in a large majority (>80%), transmitted on the same chromosome as the IRF6 mutation.

  6. CCL5 (show CCL5 Antibodies) and CXCL11 (show CXCL11 Antibodies) expression were also induced in response to the activation of the PKC (show PRRT2 Antibodies) pathway, and gene silencing experiments indicated that their inducible expression was dependent on RIPK4 (show RIPK4 Antibodies) and IRF6. Moreover, gene reporter assays suggested that RIPK4 (show RIPK4 Antibodies) induces CCL5 (show CCL5 Antibodies) and CXCL11 (show CXCL11 Antibodies) expression by stimulating the transactivation of their promoters by IRF6.

  7. IRF6 is aberrantly silenced by DNA methylation (show HELLS Antibodies) of the 5' IRF6 CGI in melanoma

  8. In all three affecteds the known pathogenic mutation c.265A>G, p.Lys89Glu in IRF6 was identified. While inter- as well as intra-familial variability has been described in IRF6-related disorders, the occurrence of a typical Van (show TNIP1 Antibodies) der (show GDF3 Antibodies) Woude Syndrome without any other anomalies as well as a diagnosis of Popliteal pterygium syndrome in the same family is rare.

  9. Association between IRF6 and 8q24 polymorphisms and nonsyndromic cleft lip with or without cleft palate

  10. Here, we demonstrate the protein functions of human IRF6 missense gene variants could be rapidly assessed in detail by their abilities to rescue the irf6 -/- phenotype in zebrafish through variant mRNA microinjections at the one-cell stage.

Zebrafish Interferon Regulatory Factor 6 (IRF6) interaction partners

  1. Here, we demonstrate the protein functions of human IRF6 missense gene variants could be rapidly assessed in detail by their abilities to rescue the irf6 -/- phenotype in zebrafish through variant mRNA microinjections at the one-cell stage.

  2. Fish IRF6 is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (show MYD88 Antibodies) and TBK1 (show TBK1 Antibodies), suggesting that differences in the IRF6 regulation pattern exist between lower and higher vertebrates.

  3. Authors report that Kruppel-like factor 17 (Klf17 (show KLF17 Antibodies)), like Grhl3 (show GRHL3 Antibodies), acts downstream of Irf6 in this network in zebrafish periderm.

  4. In zebrafish periderm, grainyhead-like 3 (grhl3 (show GRHL3 Antibodies)) (an ancient regulator of the epidermal permeability barrier), was identified as acting downstream of Irf6. Simultaneous inhibition of grhl1 (show GRHL1 Antibodies) and grhl3 (show GRHL3 Antibodies) disrupted periderm differentiation in zebrafish.

  5. analysis of zebrafish expression of IRF6

  6. These experiments reveal a conserved role for maternally-encoded Irf6 in differentiation of a simple epithelium in X. laevis and D. rerio.

Mouse (Murine) Interferon Regulatory Factor 6 (IRF6) interaction partners

  1. IRF6 expression in basal epithelium partially rescues Irf6 knockout mice

  2. Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikkalpha (show CHUK Antibodies) and Irf6.

  3. IRF6 suppresses PPARgamma (show PPARG Antibodies) through binding IRF (show TRIM63 Antibodies) recognition sites located upstream of the PPARgamma (show PPARG Antibodies) coding region. Taken together, the results suggest that an IRF6/PPARgamma (show PPARG Antibodies) regulatory axis suppresses anti-inflammatory responses in bone marrow-derived macrophages and provides references for future study addressing dysregulated metabolic and immunologic homeostasis of obese adipose tissue.

  4. Irf6 and RTK signaling interact in regulating periderm differentiation and function, as well as provide a rationale to screen for epistatic interactions between variants in IRF6 and RTK signaling pathway genes in human orofacial clefting populations.

  5. These data provide the first mechanistic insight into the heightened caries susceptibility associated with CLP (show HAPLN1 Antibodies) and indicate a direct role for the major CLP (show HAPLN1 Antibodies) gene Irf6 in salivary gland development and a significant role in regulating oral immunity in mice.

  6. that downregulation of interferon regulatory factor 6 affords protection against TNI (show TNNI2 Antibodies) through Akt (show AKT1 Antibodies)-eNOS (show NOS3 Antibodies) pathway-mediated antioxidative and anti-inflammatory activity

  7. Irf6 is required for resistance to Lipopolysaccharides-induced endotoxic shock. In addition, Irf6-deficient bone marrow-derived neutrophils exhibited increased chemotactic index and velocity compared with wild-type cells in vitro.

  8. TGFbeta3 increases IRF6 expression and subsequently regulates SNAI2 expression; IRF6 appears to regulate epithelial mesenchymal transition during palatal fusion via SNAI2.

  9. Pvrl1 (show PVRL1 Antibodies) is a bona fide target gene of the transcription factor p63 (show CKAP4 Antibodies), whereas Pvrl4 (show PVRL4 Antibodies) regulation is linked to epidermal differentiation and is under Irf6

  10. Data suggest that Irf6 functions through the RhoA (show RHOA Antibodies) pathway to regulate cellular migration.

IRF6 Antigen Profile

Protein Summary

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with IRF6

  • interferon regulatory factor 6 (IRF6) antibody
  • interferon regulatory factor 6 (irf6) antibody
  • interferon regulatory factor 6 S homeolog (irf6.S) antibody
  • interferon regulatory factor 6 (Irf6) antibody
  • AI876454 antibody
  • DKFZp469E012 antibody
  • E230028I05Rik antibody
  • IRF6 antibody
  • LPS antibody
  • mirf6 antibody
  • OFC6 antibody
  • PIT antibody
  • PPS antibody
  • PPS1 antibody
  • VWS antibody
  • VWS1 antibody
  • xIRF-6 antibody
  • zgc:63500 antibody

Protein level used designations for IRF6

interferon regulatory factor 6 , interferon regulatory factor 6-like , IRF-6

GENE ID SPECIES
443083 Ovis aries
457701 Pan troglodytes
594908 Xenopus (Silurana) tropicalis
712958 Macaca mulatta
100174467 Pongo abelii
100402804 Callithrix jacchus
100594750 Nomascus leucogenys
3664 Homo sapiens
393570 Danio rerio
443771 Xenopus laevis
480015 Canis lupus familiaris
397521 Sus scrofa
614253 Bos taurus
54139 Mus musculus
364081 Rattus norvegicus
100349520 Oryctolagus cuniculus
419863 Gallus gallus
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