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IRF6 encodes a member of the interferon regulatory transcription factor (IRF) family. Additionally we are shipping IRF6 Proteins (9) and many more products for this protein.
Showing 10 out of 97 products:
Human Polyclonal IRF6 Primary Antibody for ELISA, IHC - ABIN4327608
Hu, Liu, Li, Ozturk, Gurumurthy, Romano, Sinha, Nawshad: TGFβ3 regulates periderm removal through ΔNp63 in the developing palate. in Journal of cellular physiology 2015
Show all 5 Pubmed References
Cow (Bovine) Polyclonal IRF6 Primary Antibody for IHC, WB - ABIN2779406
Iwata, Suzuki, Pelikan, Ho, Sanchez-Lara, Urata, Dixon, Chai: Smad4-Irf6 genetic interaction and TGF?-mediated IRF6 signaling cascade are crucial for palatal fusion in mice. in Development (Cambridge, England) 2013
Two novel mutations (Arg31Thr and Trp40Glyfs *23) in the IRF6 gene were identified to be causative for Van (show TNIP1 Antibodies) der (show GDF3 Antibodies) Woude and popliteal pterygium syndromes in 6 Polish families. In the present study no association between the single nucleotide polymorphisms rs7552506, rs2013162, and rs2235375 and the cleft lip and/or palate phenotype was found.
Our results do not support the previously reported association between the A allele of rs642961 and the NSCL (show NHLH1 Antibodies) phenotype. However, in the VWS/PPS families, the A allele was a risk allele and was, in a large majority (>80%), transmitted on the same chromosome as the IRF6 mutation.
CCL5 (show CCL5 Antibodies) and CXCL11 (show CXCL11 Antibodies) expression were also induced in response to the activation of the PKC (show PRRT2 Antibodies) pathway, and gene silencing experiments indicated that their inducible expression was dependent on RIPK4 (show RIPK4 Antibodies) and IRF6. Moreover, gene reporter assays suggested that RIPK4 (show RIPK4 Antibodies) induces CCL5 (show CCL5 Antibodies) and CXCL11 (show CXCL11 Antibodies) expression by stimulating the transactivation of their promoters by IRF6.
IRF6 is aberrantly silenced by DNA methylation (show HELLS Antibodies) of the 5' IRF6 CGI in melanoma
In all three affecteds the known pathogenic mutation c.265A>G, p.Lys89Glu in IRF6 was identified. While inter- as well as intra-familial variability has been described in IRF6-related disorders, the occurrence of a typical Van (show TNIP1 Antibodies) der (show GDF3 Antibodies) Woude Syndrome without any other anomalies as well as a diagnosis of Popliteal pterygium syndrome in the same family is rare.
Association between IRF6 and 8q24 polymorphisms and nonsyndromic cleft lip with or without cleft palate
Here, we demonstrate the protein functions of human IRF6 missense gene variants could be rapidly assessed in detail by their abilities to rescue the irf6 -/- phenotype in zebrafish through variant mRNA microinjections at the one-cell stage.
The data presented suggest an important role for cytoplasmic IRF6 in regulating the availability or localization of the NME1 (show NME1 Antibodies)/2 complex and thus the dynamic behavior of epithelia during lip/palate development.
IRF6 dysregulation may be involved in the development of Vulvar Squamous Cell Carcinoma from vulvar lichen sclerosus (VLS). Methylation of the IRF6 promoter may be a marker of cancer risk in patients with VLS.
Here, the authors have established that IRF6 promotes the differentiation of oral keratinocytes in response to Porphyromonas gingivalis.
Fish IRF6 is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (show MYD88 Antibodies) and TBK1 (show TBK1 Antibodies), suggesting that differences in the IRF6 regulation pattern exist between lower and higher vertebrates.
Authors report that Kruppel-like factor 17 (Klf17 (show KLF17 Antibodies)), like Grhl3 (show GRHL3 Antibodies), acts downstream of Irf6 in this network in zebrafish periderm.
In zebrafish periderm, grainyhead-like 3 (grhl3 (show GRHL3 Antibodies)) (an ancient regulator of the epidermal permeability barrier), was identified as acting downstream of Irf6. Simultaneous inhibition of grhl1 (show GRHL1 Antibodies) and grhl3 (show GRHL3 Antibodies) disrupted periderm differentiation in zebrafish.
analysis of zebrafish expression of IRF6
These experiments reveal a conserved role for maternally-encoded Irf6 in differentiation of a simple epithelium in X. laevis and D. rerio.
Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikkalpha (show CHUK Antibodies) and Irf6.
IRF6 suppresses PPARgamma (show PPARG Antibodies) through binding IRF (show TRIM63 Antibodies) recognition sites located upstream of the PPARgamma (show PPARG Antibodies) coding region. Taken together, the results suggest that an IRF6/PPARgamma (show PPARG Antibodies) regulatory axis suppresses anti-inflammatory responses in bone marrow-derived macrophages and provides references for future study addressing dysregulated metabolic and immunologic homeostasis of obese adipose tissue.
Irf6 and RTK signaling interact in regulating periderm differentiation and function, as well as provide a rationale to screen for epistatic interactions between variants in IRF6 and RTK signaling pathway genes in human orofacial clefting populations.
These data provide the first mechanistic insight into the heightened caries susceptibility associated with CLP (show HAPLN1 Antibodies) and indicate a direct role for the major CLP (show HAPLN1 Antibodies) gene Irf6 in salivary gland development and a significant role in regulating oral immunity in mice.
that downregulation of interferon regulatory factor 6 affords protection against TNI (show TNNI2 Antibodies) through Akt (show AKT1 Antibodies)-eNOS (show NOS3 Antibodies) pathway-mediated antioxidative and anti-inflammatory activity
Irf6 is required for resistance to Lipopolysaccharides-induced endotoxic shock. In addition, Irf6-deficient bone marrow-derived neutrophils exhibited increased chemotactic index and velocity compared with wild-type cells in vitro.
TGFbeta3 increases IRF6 expression and subsequently regulates SNAI2 expression; IRF6 appears to regulate epithelial mesenchymal transition during palatal fusion via SNAI2.
Pvrl1 (show PVRL1 Antibodies) is a bona fide target gene of the transcription factor p63 (show CKAP4 Antibodies), whereas Pvrl4 (show PVRL4 Antibodies) regulation is linked to epidermal differentiation and is under Irf6
Data suggest that Irf6 functions through the RhoA (show RHOA Antibodies) pathway to regulate cellular migration.
These results support a role for IRF6 in brain morphometry and provide evidence for a potential genetic link to abnormal brain development in orofacial clefting.
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.
interferon regulatory factor 6
, interferon regulatory factor 6-like