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IL28B encodes a cytokine distantly related to type I interferons and the IL-10 family. Additionally we are shipping Interleukin 28B (Interferon, lambda 3) Antibodies (111) and Interleukin 28B (Interferon, lambda 3) Kits (27) and many more products for this protein.
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results suggest that IL-28B induces more mature NK cells to defend against viruses, in addition to its direct antiviral activity
IL-28B down-regulates Tregs following subunit vaccine ESAT6-Ag85B-Mpt64(190-198)-Mtb8.4-HspX vaccination but does not improve the protective immune responses.
the role of IFN-lambda in IDO (show IDO1 Proteins) regulation was investigated after influenza infection of respiratory epithelial cells.
Data indicate that rotavirus infection induces production of interferon (show IFNA Proteins)-lambda (IFN-lambda) and interleukin 22 (IL-22 (show IL22 Proteins)) by intestinal epithelial cells.
Acritical role of IL-28 cytokines is in controlling T cell responses in vivo through the modulation of lung CD11c (show ITGAX Proteins)(+) DC function in experimental allergic asthma.
IFN-alpha (show IFNA Proteins), IFN-beta (show IFNB1 Proteins), and IFN-gamma (show IFNG Proteins) were observed in the anterior segment of injected eyes through 72 hours and mRNA levels of IFN-beta (show IFNB1 Proteins) and IFN-gamma (show IFNG Proteins) were increased in virus-infected eyes 48 to 120 hours after herpes simplex infection
the duration of IFNlambda signaling to JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) is different from that of IFNalpha
intranasal influenza A virus infection leads to the robust type III IFN induction in the lungs of both WT and IFNAR (show IFNAR1 Proteins)-/- mice
IL-28A (show IL28A Proteins) emerges as a key regulatory cytokine with pathogenic function in T-cell-mediated liver injury
Type III interferon (show IFNA Proteins)/IL-28 targets a specific subset of cells and contributes to the antiviral response evoked by Toll (show TLR4 Proteins)-like receptors, largely mediated by inducing an antiviral state in epithelial cells.
Both hepatitis C virus-specific T cell responses and IL28B rs12979860 single-nucleotide polymorphism genotype influence anti-hepatitis C virus treatment outcome in patients with chronic hepatitis C.
IFNL3 SNPs are strongly associated with treatment responses in Iranian patients with chronic hepatitis C.
TLR2 and IL28B polymorphisms in combination showed a role in the control of HCV viral load and different HCV disease progression.
These findings indicate that serum IFNL3 levels at baseline are higher in acute hepatitis C patients regardless of the rs8099917 polymorphism, and primary hepatitis C virus infection triggers the production of IFNL3.
The association between IFNL3/4 genotypes with elevated HCV VL observed in HCV g6-infected individuals may have implications for the progression of liver disease in Southeast Asian countries where this viral genotype predominates and therefore warrants further studies.
In summary, the current study did not find a significant association between IL28B rs12979860 polymorphism and hepatocarcinogenesis.
Interferon (show IFNA Proteins) lambda polymorphisms influence regulatory pathways of cellular response to interferon (show IFNA Proteins) and affect body iron balance in chronic hepatitis C virus infection.
IL-28B rs12979860 SNP could be used as an independent predictor for treatment response among HCV patients.
In hemodialysis patients, circulating IFN-lambda3 strongly correlates with anti-HBs antibody production after HBV vaccination and infection. IFNL3 rs8099917 polymorphisms seem to be associated with IFN-lambda3 plasma levels in hemodialysis subjects.
Results demonstrated genetic variations of IL-28B might impact liver function recovery after transplantation by influencing peripheral platelet counts and reducing liver inflammation, but weak association with transplant etiologies.
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
, interferon alpha
, interferon lambda-3
, interleukin 28
, cytokine Zcyto22
, interferon lambda-4
, interferon, lambda 4
, interleukin 28B (interferon, lambda 3)
, interleukin 28C