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Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival.
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Together, these studies reveal that phosphorylation of the SIMPL protein plays a critical role in SIMPL regulation by affecting both SIMPL subcellular localization and the p65 (show GORASP1 Antibodies) coactivator function of SIMPL.
SIMPL functions as a TNFalpha (show TNF Antibodies)-dependent p65 (show NFkBP65 Antibodies) co-activator by facilitating the recruitment of MED1 (show MBD4 Antibodies) to p65 (show NFkBP65 Antibodies) containing transcriptional complexes to control the expression of a subset of TNFalpha (show TNF Antibodies)-induced genes.
IRAK1BP1 functions through its effects on NF-kappaB (show NFKB1 Antibodies) as a molecular switch to bias innate immune pathways toward the resolution of inflammation
Signals transduced through the tumor necrosis factor-alpha-tumor necrosis factor (show TNF Antibodies) -receptor I-SIMPL(substrate that interacts with mouse pelle (show IRAK1 Antibodies)-like kinase) pathway support hematopoietic progenitor cell survival, growth and differentiation
TNF-alpha (show TNF Antibodies) activation of NF-kappaB (show NFKB1 Antibodies) dependent-gene expression requires nuclear relocalization of p65 (show NFkBP65 Antibodies) as well as nuclear relocalization of SIMPL, generating a TNF-alpha (show TNF Antibodies)-specific induction of gene expression.
Hsp70/Hsc70 bind the intrinsically disordered amino-terminal region of SIMPL to stabilize the protein and thereby regulate its activity.
IRAK1BP1 regulates transcription of a specific subset of Toll (show TLR4 Antibodies)-like receptor responsive genes, producing an overall antiinflammatory profile
Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity).
interleukin-1 receptor-associated kinase 1 binding protein 1
, ActA binding protein 3
, interleukin-1 receptor-associated kinase 1-binding protein 1
, Acta binding protein 3
, Acta-binding protein 70
, Plk-interacting protein
, signaling molecule that associates with the mouse pelle-like kinase
, interleukin-1 receptor-associated kinase 1-binding protein 1 homolog