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Plays a key role in ciliogenesis and embryonic development. Additionally we are shipping INTU Proteins (4) and and many more products for this protein.
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propose a role for Intu in protecting cells and tissues after injury by targeting STAT1 for degradation and maintaining primary cilia
Mice with a recessive hypomorphic Intu missense mutation affecting a conserved hydrophobic residue (I813N) near the C-terminus display polydactyly, retarded growth, skeletal defects, reduced survival, and a moderate loss of cilia.
Targeting Intu in the epidermis resulted in almost complete loss of primary cilia in epidermal and follicular keratinocytes, and a suppressed hedgehog signaling pathway.
Data show that the functions of both Inturned and Fuzzy in neural tube patterning are dependent on the presence of cilia.
Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity).
PDZ domain-containing protein 6
, protein inturned
, PDZ domain containing 6
, homolog of inturned
, inturned planar cell polarity effector homolog