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Histone demethylase required for brain development. Additionally we are shipping and many more products for this protein.
Showing 10 out of 37 products:
increased JHDM1D expression suppresses tumor growth by down-regulating angiogenesis under nutrient starvation
The KIAA1718, a PHF2/PHF8 subfamily member, possesses histone demethylase activity specific for H3K9 and H3K27, transcriptionally repressive histone marks.
a JmjC domain-containing protein that catalyzes demethylation of both mono- or dimethylated H3K9 and H3K27 [KDM7]
KDM7A mediates TNF-alpha-induced ICAM1 protein upregulation.
G9a promotes H3K27 methylation of the E-cadherin promoter by upregulating PCL3 to increase PRC2 promoter recruitment and by downregulating the H3K27 demethylase KDM7A to silence E-cadherin gene
Histone modifier genes (JMJD1C, RREB1, MINA, KDM7A) alter conotruncal heart phenotypes in 22q11.2 deletion syndrome.
KIAA1718 is a dual-specificity histone demethylase that regulates neural differentiation through FGF4.
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (By similarity).
jmjC domain-containing histone demethylation protein 1D
, lysine-specific demethylase 7
, histone lysine demethylase JHDM1D
, jumonji C domain-containing histone demethylase 1 homolog D
, JmjC domain-containing histone demethylation protein 1D-B
, lysine-specific demethylase 7B
, jumonji C domain containing histone demethylase 1 homolog D
, lysine-specific demethylase 7A
, jumonji C domain containing histone demethylase 1
, lysine (K)-specific demethylase 7A
, lysine (K)-specific demethylase 7A L homeolog