Junctional Adhesion Molecule 3 (JAM3) ELISA Kits

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. Additionally we are shipping JAM3 Antibodies (91) and JAM3 Proteins (14) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
JAM3 83964 Q9D8B7
JAM3 83700 Q9BX67
JAM3 315509 Q68FQ2
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Top JAM3 ELISA Kits at antibodies-online.com

Showing 3 out of 13 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Mouse 1.95 pg/mL 7.8-500 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details
Human 9.75 pg/mL 39-2500 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details
Rat 1.56 pg/mL 6.25-400 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details

More ELISA Kits for JAM3 Interaction Partners

Zebrafish Junctional Adhesion Molecule 3 (JAM3) interaction partners

  1. The studies demonstrate that although Jamb, Jamc, and Mymk are all involved in myoblast fusion during early myogenesis, they have distinct roles in myoblast fusion during muscle growth. While Mymk is essential for myoblast fusion during both muscle development and growth, Jamb and Jamc are dispensable for myoblast fusion during muscle growth.

  2. interaction between Jamb and Jamc expressed by neighbouring cells is essential for fusion. jamc is ectopically expressed in prdm1a mutant slow muscle precursors, which inappropriately fuse with other myocytes.

Mouse (Murine) Junctional Adhesion Molecule 3 (JAM3) interaction partners

  1. Jam-c gene deletion resulted in smaller eyes and decreased photoreceptor numbers.

  2. The role of JAM-C on the aging of neutrophils to cause sepsis-induced acute lung injury was studied. JAM-C not only regulates neutrophil chemotaxis but also prolongs their survival by promoting anti-apoptotic function.

  3. this study shows that JAM-C promotes autoimmune-mediated liver fibrosis in mice

  4. the dimerization sites E66-K68 of JAM-C affected cell adhesion, polarization and migration and are essential for tumor cell metastasis.

  5. JAM-C plays an important role in maintaining VEGR2 expression to promote retinal pigment epithelial cell survival under oxidative stress.

  6. JAM-B/JAM-C mediated interaction between endothelial cells and stellate cells stabilizes vessel walls and may control the sinusoidal diameter.

  7. Study provides evidence that JAM-C downregulation may contribute to acute pancreatitis-associated lung injury via reverse transendothelial migration of neutrophils.

  8. Endothelial-specific deletion of JAM-C promoted endothelial cell sprouting, and consequently vessel normalisation and revascularisation of the hypoxic retina without altering pathologic neovascularisation.

  9. JAM-C blockade can finely-tune the innate cell migration and accelerate the consequent immune response to L. major without changing the type of the T helper cell response.

  10. Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells.

  11. These findings provide evidence for a role for endothelial cell JAM-C in tumor growth and aggressiveness as well as recruitment of pericytes to newly formed blood vessels in a model of ovarian cancer.

  12. JAM-C might be involved in the final steps of trafficking and transmigration of antigen-specific autoaggressive T-cells to the islets of Langerhans.

  13. study suggests that JAM-C(-/-) C57BL/6 mice model the important role for JAM-C in brain development and CSF homeostasis as recently observed in humans with a loss-of-function mutation in JAM-C

  14. Data show that junctional adhesion molecule-B (JAM-B) expressed by endothelial cells contributes to murine B16 melanoma cells metastasis through its interaction with junctional adhesion molecule-C (JAM-C) on tumor cells.

  15. Results indicate that in vivo JAM-C shows enrichment at the apical surface and therefore is asymmetrically distributed during cell divisions.

  16. Data indicate deletion of JAM-C in deletion of JAM-C in Schwann cells (SCs) (JAM-C SC KO) mice showed electrophysiological defects, muscular weakness, and hypersensitivity to mechanical stimuli.

  17. Endothelial cell JAM-C has a key role in supporting luminal-to-abluminal migration of neutrophils in vivo, suggsting that reverse transepithial cell migration of neutrophils can contribute to the dissemination of systemic inflammation.

  18. Thrombomodulin and platelet-derived growth factor receptor alpha (PDGFRalpha) identify a population of fibroblastic reticular cells in lymph nodes where chemokine secretion is controlled by JAM-C.

  19. JAM-C(-/-) mice as well as endothelial-specific JAM-C-deficient mice displayed significantly decreased B16 melanoma cell metastasis to the lung, whereas treatment of mice with soluble JAM-C prevented melanoma lung metastasis

  20. a cell-surface protein of the immunoglobulin superfamily, junctional adhesion molecule-C (JAM-C), is critically required for the differentiation of round spermatids into spermatozoa in mice [JAM-C]

Human Junctional Adhesion Molecule 3 (JAM3) interaction partners

  1. Jam3 enhances the migratory ability of renal carcinoma cells. Jam3 degeneration induces apoptosis of renal carcinoma cells. The knockdown of Jam3 inhibited renal carcinoma cell migration and promoted renal carcinoma cell apoptosis.

  2. LPS mediates intercellular tight junction destruction among TECs and RhoT1/SMAD-4/JAM-3 is a pivotal pathway to mediate the phenomenon.

  3. JAM-C plays an important role in maintaining VEGR2 expression to promote retinal pigment epithelial cell survival under oxidative stress.

  4. JAM-C controls Src family kinase (SFK) activation in leukemic stem cells and leukemia-initiating cell activity with exacerbated SFK activation was uniquely found within the JAM-C-expressing leukemic stem cell compartment.

  5. The role of JAM-C in the engraftment of human lymphoma B cells in mice was investigated. The binding of anti-JAM-C antibodies inhibited the phosphorylation of ERK1/2, without affecting other signaling pathways, identifying for the first time the intracellular MAPK cascade as the JAM-C-driven signaling pathway in JAM-C(+) B cells.

  6. blocking JAM-C can reduce the number of atherogenic monocytes/macrophages in plaques by emigration.

  7. Palmitoylation of JAM-C promotes its localization to tight junctions and inhibits transwell migration of A549 lung cancer cells.

  8. Study provides evidence that JAM-C downregulation may contribute to acute pancreatitis-associated lung injury via reverse transendothelial migration of neutrophils.

  9. Suggest JAM3-M4 methylation as a biomarker for diagnosis of preneoplastic and neoplastic lesions of the cervix.

  10. JAM-C inactivation in endothelial cells resulted in increased spreading on fibronectin and enhanced sprouting in vitro in a manner dependent on beta1-integrin and on the activation of the small GTPase RAP1.

  11. Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells.

  12. indicate that JAM-C may be a therapeutic target for preventing and treating lymphatic metastases

  13. These findings provide evidence for a role for endothelial cell JAM-C in tumor growth and aggressiveness as well as recruitment of pericytes to newly formed blood vessels in a model of ovarian cancer.

  14. Our study confirms the importance of JAM3 as a component of the junctional complexes and its deficiency leading to a distinctive and catastrophic neonatal presentation of cataracts and hemorrhagic destruction of the brain.

  15. These data brought new evidences for the role of JAM2 and JAM3 in progression of gastric adenocarcinoma

  16. In the present study, we investigated the role of JAM-C in homing of human B cells, using a xenogeneic nonobese diabetic/severe combined immunodeficient mouse model.

  17. Data suggest that the four-gene methylation panel might provide an alternative triage test after primary high-risk papillomavirus (hr-HPV) testing.

  18. JAM-C expression was identified in human and murine melanoma cell lines, in human malignant melanoma, as well as in metastatic melanoma including melanoma lung metastasis

  19. Our results suggest that JAM3 is essential for maintaining the integrity of the cerebrovascular endothelium as well as for normal lens development in humans

  20. Soluble JAM-C mediates facets of angiogenesis in vitro and contributes the angiogenic potential of rheumatoid arthritis synovial fluid.

JAM3 Antigen Profile

Antigen Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with JAM3

  • junctional adhesion molecule 3 (JAM3) antibody
  • junctional adhesion molecule 3b (jam3b) antibody
  • junctional adhesion molecule 3a (jam3a) antibody
  • junction adhesion molecule 3 (Jam3) antibody
  • junctional adhesion molecule 3 (Jam3) antibody
  • 1110002N23Rik antibody
  • JAM-2 antibody
  • JAM-3 antibody
  • JAM-C antibody
  • jam3 antibody
  • JAMC antibody
  • jamc.2 antibody
  • Jcam3 antibody
  • sr:nyz155 antibody
  • wu:fb30h11 antibody
  • wu:fc08c06 antibody
  • wu:fc13e04 antibody
  • wu:fc25g11 antibody

Protein level used designations for JAM3

junctional adhesion molecule 3 , jamc , jamc.1 , si:ch211-277g22.3 , JAM-C-like protein , junction cell adhesion molecule 3 , junction cell adhesion molecule C , junctional adhesion molecule C , JAM-3 , JAM-C

GENE ID SPECIES
419736 Gallus gallus
451678 Pan troglodytes
569217 Danio rerio
797651 Danio rerio
83964 Mus musculus
83700 Homo sapiens
489271 Canis lupus familiaris
513412 Bos taurus
315509 Rattus norvegicus
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