anti-Keratin 8 (KRT8) Antibodies

KRT8 is a member of the type II keratin family clustered on the long arm of chromosome 12.

list all antibodies Gene Name GeneID UniProt
Anti-Human KRT8 KRT8 3856 P05787
Anti-Mouse KRT8 KRT8 16691 P11679
Anti-Rat KRT8 KRT8 25626 Q10758
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Top anti-Keratin 8 Antibodies at antibodies-online.com

Showing 10 out of 994 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-KRT8 Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate KRT8 is supported by BioGPS gene expression data to be expressed in HepG2 Immunohistochemistry with Small intestine tissue at an antibody concentration of 5µg/ml using anti-KRT8 antibody (ARP42029_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-KRT8 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Jurkat cell lysate Rabbit Anti-KRT8 Antibody  Paraffin Embedded Tissue: Human Kidney Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated FACS, IHC (fro), IF, IHC (p), WB   0.1 mg Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: Cytokeratin 8 Antibody [NBP2-16094] - Immunohistochemical analysis of paraffin-embedded Gastric ca, using antibody at 1:500 dilution. Western Blot: Cytokeratin 8 Antibody [NBP2-16094] - Sample (30 ug of whole cell lysate) A: JC 10% SDS PAGE gel, diluted at 1:10000. 0.1 mL Log in to see 7 to 9 Days
$556.31
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Cytokeratin 8 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Cytokeratin 8 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Cytokeratin 8 staining in DLD cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Cytokeratin 8 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Cow Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Cytokeratin 8 staining in NIH3T3 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Cytokeratin 8 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of Cytokeratin 8 (pS73) expression in HeLa (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$575.00
Details
Human Mouse Un-conjugated IF, IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Dog Mouse Un-conjugated IF, IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$507.83
Details

Top referenced anti-Keratin 8 Antibodies

  1. Human Monoclonal KRT8 Primary Antibody for ICC, FACS - ABIN335327 : Ivanyi, Groeneveld, Van Doornewaard, Mooi, Hageman: Keratin subtypes in carcinomas of the uterine cervix: implications for histogenesis and differential diagnosis. in Cancer research 1990 (PubMed)
    Show all 10 Pubmed References

  2. Hamster Monoclonal KRT8 Primary Antibody for IHC (fro), IHC (p) - ABIN920532 : Moll, Franke, Schiller, Geiger, Krepler: The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. in Cell 1983 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal KRT8 Primary Antibody for ICC, IHC (fro) - ABIN920530 : Troyanovsky, Guelstein, Tchipysheva, Krutovskikh, Bannikov: Patterns of expression of keratin 17 in human epithelia: dependency on cell position. in Journal of cell science 1990 (PubMed)
    Show all 4 Pubmed References

  4. Human Polyclonal KRT8 Primary Antibody for IF (cc), IF (p) - ABIN737751 : Zhang, Li, Fu, Li: Calcitonin is expressed in the submaxillary glands of rats. in Bosnian journal of basic medical sciences / Udruženje basi?nih mediciniskih znanosti = Association of Basic Medical Sciences 2014 (PubMed)
    Show all 3 Pubmed References

  5. Human Monoclonal KRT8 Primary Antibody for IF, IHC - ABIN965965 : Walker, Harris, Holloway, McKenzie, Wells, Robinson, Morris: Cytokeratin KRT8/18 expression differentiates distinct subtypes of grade 3 invasive ductal carcinoma of the breast. in Cancer genetics and cytogenetics 2007 (PubMed)
    Show all 2 Pubmed References

  6. Chicken Monoclonal KRT8 Primary Antibody for IHC (fro), IHC (p) - ABIN268153 : Rossdeutscher, Li, Luco, Fadhil, Ochietti, Camirand, Huang, Reinhardt, Muller, Kremer: Chemoprevention activity of 25-hydroxyvitamin D in the MMTV-PyMT mouse model of breast cancer. in Cancer prevention research (Philadelphia, Pa.) 2015 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal KRT8 Primary Antibody for IHC (fro), IHC (p) - ABIN284054 : Fernandez-Valdivia, Mukherjee, Ying, Li, Paquet, DeMayo, Lydon: The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse. in Developmental biology 2009 (PubMed)
    Show all 2 Pubmed References

  8. Human Monoclonal KRT8 Primary Antibody for IHC (fro), IHC (p) - ABIN284055 : Bardag-Gorce, Oliva, Li, French, French: SAMe prevents the induction of the immunoproteasome and preserves the 26S proteasome in the DDC-induced MDB mouse model. in Experimental and molecular pathology 2010 (PubMed)
    Show all 2 Pubmed References

  9. Human Monoclonal KRT8 Primary Antibody for ICC, IHC (p) - ABIN94298 : Bártek, Vojt?sek, Stasková, Bártková, Kerekés, Rejthar, Kovarík: A series of 14 new monoclonal antibodies to keratins: characterization and value in diagnostic histopathology. in The Journal of pathology 1991 (PubMed)

More Antibodies against Keratin 8 Interaction Partners

Human Keratin 8 (KRT8) interaction partners

  1. K8/K18 (show KRT18 Antibodies) variants are overrepresented in Chinese NAFLD (show TSC2 Antibodies) patients and might accelerate liver fat storage through insulin (show INS Antibodies) resistance.

  2. regulated enhancement of autophagy with concurrent increased expression of KRT8 and the inhibition of KRT8 phosphorylation serve to inhibit oxidative stress-induced (show SQSTM1 Antibodies) epithelial-mesenchymal transitionof retinal pigment epithelium cells.

  3. Histopathological differences between Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU)-ablated tissue and radiofrequency (RF)-ablated tissue were demonstrated. CK-8 was more reliable for cell viability assessment than H&E when used directly after ablation

  4. Loss of activating transcription factor 3 (ATF3 (show ATF3 Antibodies)) in knockout mice promotes the emergence of keratins CK5 (show KRT5 Antibodies)+CK8+ epithelial cells.

  5. Data show that the filament elongation of both desmin (show DES Antibodies) and keratin K8/K18 (show KRT18 Antibodies) proceeds very similar to that of vimentin (show VIM Antibodies).

  6. New insights into interactions between the nucleotide-binding domain of CFTR (show CFTR Antibodies) and keratin 8.

  7. We present results of a multicentre study measuring UBC (show RPS27A Antibodies)((R)) Rapid Test(test that detects fragments of cytokeratins 8 and 18 in urine) in bladder cancer patients and healthy controls with focus on carcinoma in situ (CIS (show CISH Antibodies)) and high-grade bladder cancer.

  8. Data show that after siRNA transfection, TGF-beta1 (show TGFB1 Antibodies) protein level was decreased, and CK18 (show KRT18 Antibodies) proteins was decreased, while CK8 proteins was increased, and TERT (show TERT Antibodies) protein expression was slightly increased at 96 h.

  9. The interplay between Solo protein and keratin 8/keratin 18 filaments plays a crucial role in tensile force-induced RhoA activation and consequent actin cytoskeletal reinforcement in endothelial cells.

  10. K8/18 filaments provide resistance to apoptosis in granulosa cell tumor cells by impairing FAS (show FAS Antibodies) expression.

Mouse (Murine) Keratin 8 (KRT8) interaction partners

  1. The authors found that keratin 8 suppressed toll (show TLR4 Antibodies)-like receptor-induced nuclear factor (NF)-kappaB (show NFKB1 Antibodies) activation and interacted with the adaptor tumor necrosis factor (TNF (show TNF Antibodies)) receptor-associated factor 6 (TRAF6 (show TRAF6 Antibodies)) to prevent its polyubiquitination.

  2. K8/K18 (show KRT18 Antibodies) interact with Notch1 (show NOTCH1 Antibodies) and regulate Notch1 (show NOTCH1 Antibodies) signalling activity during differentiation of the colonic epithelium.

  3. Mitochondria in K8 wild-type beta cells and MIN6 insulinoma cells overexpressing K8 and 18 are more stationary compared with mitochondria in keratin-deficient cells

  4. K8/K18 (show KRT18 Antibodies)-dependent PKCdelta (show PKCd Antibodies)- and ASMase (show SMPD1 Antibodies)-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (show KRT18 Antibodies) loss.

  5. DRA mRNA levels were decreased by three- to fourfold and DRA protein was almost entirely lost in K8-/- cecum and proximal and distal colon compared with K8+/+.

  6. Upregulation of IL-22 (show IL22 Antibodies) in combination with a complete loss of its negative regulator IL-22BP (show IL22RA2 Antibodies), and increased downstream STAT3 (show STAT3 Antibodies)-signaling in K8(-/-) and K8(-/-)Apc (show APC Antibodies)(Min/+) colonic epithelia confirmed that the IL-22 (show IL22 Antibodies) pathway, important in inflammation, proliferation and tissue regeneration

  7. Krt8 deletion (Krt8(-/-)) in a mouse model of cystic fibrosis (show S100A8 Antibodies) (F508del-Cftr (show CFTR Antibodies) mice) increased the levels of circulating markers of bone formation, corrected the expression of osteoblast phenotypic genes, promoted trabecular bone formation and improved bone mass and microarchitecture. Krt8 deletion corrected overactive NF-kappaB (show NFKB1 Antibodies) signaling & decreased Wnt (show WNT2 Antibodies)-beta-catenin (show CTNNB1 Antibodies) signaling induced by F508del-Cftr (show CFTR Antibodies) mutation in osteoblasts.

  8. Autoantibodies to several antigens were identified in 81% of K8-null male mice 8 mo or older. Similar autoantibodies were detected in aging K18 (show KRT18 Antibodies)-null male mice that had a related liver phenotype but normal colon compared with K8-null mice

  9. The regulation of the SCFA-MCT1 (show MCTS1 Antibodies)-HMGCS2 (show HMGCS2 Antibodies) axis is disrupted in K8(-/-) colonocytes, suggesting a role for keratins in colonocyte energy metabolism and homeostasis.

  10. In several liver stress models epiplakin and K8 genes displayed identical expression patterns and transgenic K8 overexpression resulted in elevated hepatic epiplakin levels.

Cow (Bovine) Keratin 8 (KRT8) interaction partners

  1. Results did not support that K8/K18 (show KRT18 Antibodies) filaments influence the expression of Fas (show FAS Antibodies) on the surface of luteal cells.

Zebrafish Keratin 8 (KRT8) interaction partners

  1. Data identify Danio rerio keratins 8/18 as the true orthologs of the human keratin pair 8/18.

Pig (Porcine) Keratin 8 (KRT8) interaction partners

  1. This study reveals clear genetic-statistical evidence for a link of KRT8, FAF1 (show FAF1 Antibodies) and PTH1R (show PTH1R Antibodies) with some of leg weakness related traits in pigs.

  2. Mechanical injury of vascular smooth muscle up-regulated keratin 8.

Keratin 8 (KRT8) Antigen Profile

Protein Summary

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with anti-Keratin 8 (KRT8) Antibodies

  • keratin 8 (KRT8) antibody
  • keratin 8 (Krt8) antibody
  • keratin 8 S homeolog (krt8.S) antibody
  • keratin 8 (krt8) antibody
  • AA960620 antibody
  • AL022697 antibody
  • AU019895 antibody
  • card2 antibody
  • cb186 antibody
  • CK-8 antibody
  • ck8 antibody
  • cyk8 antibody
  • CYKER antibody
  • DKFZp468F2127 antibody
  • DreK8 antibody
  • EndoA antibody
  • k2c8 antibody
  • K8 antibody
  • KERATIN8 antibody
  • KO antibody
  • Krt-2.8 antibody
  • krt2-5 antibody
  • krt2-8 antibody
  • KRT8 antibody
  • MGC69490 antibody
  • sb:cb186 antibody
  • wu:fa20h05 antibody
  • wu:fa95h10 antibody
  • wu:fb96c06 antibody
  • zf-K8 antibody
  • zfk8 antibody

Protein level used designations for anti-Keratin 8 (KRT8) Antibodies

cytokeratin 8 , cytokeratin-8 , keratin, type II cytoskeletal 8 , type-II keratin Kb8 , CK-8 , cytokeratin endo A , keratin complex 2, basic, gene 8 , keratin-8 , K8 , KERA , cytokeratin-A , keratin 8 , keratin complex 2, basic, gene 5 , etID33550.23 , etID43142.23 , etID43142.8 , keratin, type 2, gene 8

GENE ID SPECIES
3856 Homo sapiens
16691 Mus musculus
25626 Rattus norvegicus
281269 Bos taurus
380217 Xenopus laevis
426896 Gallus gallus
431676 Xenopus (Silurana) tropicalis
486513 Canis lupus familiaris
700449 Macaca mulatta
737628 Pan troglodytes
797433 Danio rerio
100152077 Sus scrofa
100174430 Pongo abelii
101110495 Ovis aries
100348891 Oryctolagus cuniculus
100736243 Cavia porcellus
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