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Receptor on natural killer (NK) cells for class I MHC.. Additionally we are shipping and many more products for this protein.
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Mouse (Murine) Polyclonal Klra3 Primary Antibody for IHC - ABIN966460
Wong, Freeman, Kelleher, Mager, Takei: Ly-49 multigene family. New members of a superfamily of type II membrane proteins with lectin-like domains. in Journal of immunology (Baltimore, Md. : 1950) 1991
Show all 3 Pubmed References
This docking mode was conserved with that previously observed for Ly49C.H-2K(b) Indeed, structure-guided mutation of Ly49C indicated that Ly49C.H2-Q10 and Ly49C.H-2K(b) possess similar energetic footprints focused around residues located within the Ly49C beta4-stand and L5 loop, which contact the underside of the peptide-binding platform floor.
murine cytomegalovirus infection results in altered NK cell activation
we have shown for the first time how the differential expression of the Ly49 inhibitory receptors during ontogeny can affect NK cell function
This study showed that mPer2 is a critical clock component in modulating circadian rhythms in bone marrow, and it implies that Ly49C and Nkg2d may play an important role in mediating mPer2-controlled cytotoxic response.
Three mutations have been introduced in Ly49C that correspond to Ly49A residues close to H-2Dd in the co-crystal, demonstrating that MHC class I binding by Ly49C is dependent on residues in the same area as that used by Ly49A for ligand contacts.
The repertoire of inhibitory Ly49 receptors may be formed under the influenced of Fyn-dependent NK cell activation as well as the respective MHC class I environment.
signaling through the mouse NK inhibitory receptor Ly49C requires the presence of H-2Kb and this signaling is prevented when H-2Kb is ablated by pulsing with a peptide that can bind to it with high affinity
adoptive infusion of alloreactive NK cells with silenced Ly49C gene results in suppression of graft-versus-host disease
Receptor on natural killer (NK) cells for class I MHC.
T-cell surface glycoprotein Ly-49C
, killer cell lectin-like receptor 3
, lymphocyte antigen 49c
, natural killer cell-associated antigen 2