anti-Kv Channel Interacting Protein 3, Calsenilin (KCNIP3) Antibodies

KCNIP3 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Additionally we are shipping Kv Channel Interacting Protein 3, Calsenilin Proteins (13) and Kv Channel Interacting Protein 3, Calsenilin Kits (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNIP3 30818 Q9Y2W7
KCNIP3 56461 Q9QXT8
KCNIP3 65199 Q9JM47
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Top anti-Kv Channel Interacting Protein 3, Calsenilin Antibodies at antibodies-online.com

Showing 10 out of 147 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-CSEN Antibody Titration:  0.2-1 ug/ml  Positive Control:  Jurkat cell lysate Human kidney 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Kcnip3 Antibody   Titration: 1.0 ug/ml   Positive Control: Mouse Pancreas 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μg 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from MCF-7/Jurkat/A549 cells, using Calsenilin/KCNIP3 (Ab-63) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Calsenilin/KCNIP3 (Ab-63) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from K562 cells treated with forskolin 40nM 30' and 293 cells treated with PMA 125ng/ml 30', using Calsenilin/KCNIP3 (Phospho-Ser63) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain, using Calsenilin/KCNIP3 (Phospho-Ser63) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6268873 at 1/100 staining Human breast cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of Calsenilin/KCNIP3 expression in A431 cells.The lane on the left is treated with the antigen-specific peptide. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB WB Image Western Blot analysis of KCNIP3 expression in transfected 293T cell line by KCNIP3 polyclonal antibody. A: Non-transfected lysate. B: KCNIP3 transfected lysate. 12% SDS PAGE antibody diluted at 1:500 WB Image Sample (50 ug of whole cell lysate) A: Mouse brain 12% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Details

Top referenced anti-Kv Channel Interacting Protein 3, Calsenilin Antibodies

  1. Mammalian Monoclonal KCNIP3 Primary Antibody for ISt, IHC - ABIN1304731 : Menegola, Trimmer: Unanticipated region- and cell-specific downregulation of individual KChIP auxiliary subunit isotypes in Kv4.2 knock-out mouse brain. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 (PubMed)
    Show all 16 Pubmed References

  2. Human Polyclonal KCNIP3 Primary Antibody for IHC (p), ELISA - ABIN544576 : Schrader, Anderson, Mayne, Pfaffinger, Sweatt: PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal KCNIP3 Primary Antibody for ELISA, WB - ABIN4287519 : Rivas, Mellström, Torres, Cali, Ferrara, Terracciano, Zannini, Morreale de Escobar, Naranjo: The DREAM protein is associated with thyroid enlargement and nodular development. in Molecular endocrinology (Baltimore, Md.) 2009 (PubMed)

  4. Cow (Bovine) Polyclonal KCNIP3 Primary Antibody for IHC, WB - ABIN2777506 : Zaidi, Thomson, Choi, Buxbaum, Wasco: Intracellular calcium modulates the nuclear translocation of calsenilin. in Journal of neurochemistry 2004 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Kv Channel Interacting Protein 3, Calsenilin Interaction Partners

Human Kv Channel Interacting Protein 3, Calsenilin (KCNIP3) interaction partners

  1. Data show that Ca(2+)-binding protein (KChIP3) levels regulate baseline Mucin 5AC (MUC5AC) secretion.

  2. this study shows that human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway

  3. TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.

  4. targeting SmgGDS induces nucleolar stress, resulting in profound loss of DREAM target gene expression required for G1, S and G2 progression, and ultimately resulting in cell cycle arrest.

  5. Disruption of DREAM and RB-E2F complexes by oncoproteins from DNA tumor viruses leads to upregulation of cell cycle genes and impairs growth-inhibiting pathways, including the p53-mediated downregulation of cell cycle genes. [review]

  6. This study shows the application of hydrogen-deuterium exchange mass spectrometry and site-directed mutagenesis to investigate the Ca(2+) binding properties and the subsequent conformational changes of full-length DREAM. EF-hands undergo large conformation changes upon calcium binding even though the EF-1 hand is not capable of binding to Ca(2+).

  7. Our approach yields high confidence ranked target gene maps for TP53, DREAM, MMB-FOXM1 and RB-E2F and enables prediction and distinction of CC regulation. A web-based atlas at www.targetgenereg.org enables assessing the regulation of any human gene of interest.

  8. downregulation of these genes through the p53-p21-DREAM-CDE/CHR pathway appears to be a principal mechanism for G2/M cell cycle arrest by p53.

  9. The aim of this study was to investigate somatic mutations and DREAM gene expression in human multinodular goiter

  10. Imatinib induces GIST cell quiescence in vivo and that this process also involves the DREAM complex.

  11. Our results support the hypothesis that KChIPs enhances Kv4.2 functional expression by a 1 : 1 suppression of the N-terminal FERN domain and by producing additional positive regulatory effects on functional channel expression.

  12. GCM1-directed villous trophoblast differentiation is repressed by DREAM

  13. p53 can repress transcription of cell cycle genes through a p21(WAF1/CIP1)-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements.

  14. Genetic variation in the DREAM pathway genes was associated with the extent of pain reporting in a population-based cohort.

  15. The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function.

  16. expression of calsenilin leads to a disruption of presenilin 1/gamma-secretase-mediated epsilon-cleavage of N-cadherin, which results in the significant accumulation of N-cadherin C-terminal fragment 1

  17. The results show that continued human papillomavirus 16 E6/E7 expression is necessary in cervical cancer cells to prevent cell-cycle arrest by a repressive p130-DREAM complex.

  18. These findings suggest that calsenilin degradation is primarily mediated by the UPP and that impairment in the UPP may contribute to the involvement of calsenilin in disease-associated neurodegeneration.

  19. apoptosis inducers as diverse as oncoprotein inhibitors and cell death receptor activators trigger Hrk expression via blockade of DREAM in leukemia cells

  20. Immunoreactivity of calsenilin in the hippocampus derived from an epilepsy patient is significantly decreased compared with normal brain.

Mouse (Murine) Kv Channel Interacting Protein 3, Calsenilin (KCNIP3) interaction partners

  1. calsenilin controls the activity of neuronal RyRs.

  2. DREAM inhibition markedly improves ATF6 processing in the hippocampus and that it might contribute to a delay in memory decline in Huntington mice.

  3. Genome-wide analysis of trigeminal neurons in daDREAM transgenic mice identified cathepsin L and the monoglyceride lipase as two new DREAM transcriptional targets related to pain.

  4. Our findings demonstrate for the first time that DREAM plays an important role in thrombosis and hemostasis in mice.

  5. association of PS1 carboxyl peptide (residues 445-467, HL9) with DREAM is calcium dependent and stabilized by a cluster of three aromatic residues: F462 and F465 from PS1 and F252 from DREAM.

  6. DREAM plays an important role in structural plasticity in the hippocampus.

  7. Terbium(III) binding preserves the folding state of DREAM with minimal changes to overall structure of DREAM.

  8. Results presented in this study show for the first time that down-regulation of DREAM promotes the degeneration of RGCs, amacrine cells, and bipolar cells.

  9. The association of calcium-bound calmodulin (CaM) with DREAM is mediated by a short amphipathic amino acid sequence located between residues 29 and 44 on DREAM.

  10. The protein DREAM decreases development of L-DOPA-induced dyskinesia in mice and reduces L-DOPA-induced expression of FosB, phosphoacetylated histone H3, and dynorphin-B in the striatum

  11. NS5806 directly interacts with KChIP3 and modulates the interactions between this calcium-binding protein and the T1 domain of the Kv4.3 channels through reorientation of helix 10 on KChIP3

  12. These results provide the first evidence that DR/C/K3 plays a timing-dependent role in estradiol regulation of learning, memory, and plasticity.

  13. studies define the critical opposing functions of DREAM and USF1 in inhibiting and inducing A20 expression

  14. DREAM is a major master switch transcription factor.

  15. GCM1-directed villous trophoblast differentiation is repressed by DREAM

  16. Expression of DREAM in neuroblastoma cells enhances cisplatin mediated caspase-3 activity.

  17. Restoring CANT1 levels in neuroblastoma clones recovered the phenotype, thus confirming a key role of CANT1, and of the regulation of its gene by DREAM, in the control of protein synthesis and degradation

  18. In cardiomyocytes, [Ca2+]i-activated calmodulin kinase II (CaMKII) activates downstreamregulatory element (DRE) binding transcription factor DREAM, which consequently suppresses the expression of L-type calcium channel 1C-subunit gene (Cacna1c).

  19. Sumoylation regulates the nuclear localization of DREAM in differentiated neurons.

  20. endogenous BDNF is involved in spinal sensitization following inflammation and blockade of BDNF induction in DREAM transgenic mice underlies the failure to develop spinal sensitization

Zebrafish Kv Channel Interacting Protein 3, Calsenilin (KCNIP3) interaction partners

  1. zebrafish calsenilin is involved in endocrine cell differentiation and morphogenesis within the pancreas

Kv Channel Interacting Protein 3, Calsenilin (KCNIP3) Antigen Profile

Protein Summary

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with KCNIP3

  • potassium voltage-gated channel interacting protein 3 (KCNIP3) antibody
  • Kv channel-interacting protein 4 (LOC5568664) antibody
  • calsenilin (CpipJ_CPIJ002549) antibody
  • calsenilin (Tsp_05009) antibody
  • Kv channel interacting protein 3, calsenilin (Kcnip3) antibody
  • potassium voltage-gated channel interacting protein 3 (Kcnip3) antibody
  • Kv channel interacting protein 3b, calsenilin (kcnip3b) antibody
  • Kv channel interacting protein 3, calsenilin (KCNIP3) antibody
  • potassium voltage-gated channel interacting protein 3 (kcnip3) antibody
  • 4933407H12Rik antibody
  • AI413860 antibody
  • csen antibody
  • Dream antibody
  • im:7145308 antibody
  • KChIP3 antibody
  • KCNIP3 antibody
  • R74849 antibody
  • rKChIP3 antibody
  • zgc:73306 antibody

Protein level used designations for KCNIP3

A-type potassium channel modulatory protein 3 , DRE-antagonist modulator , calsenilin , calsenilin, presenilin-binding protein, EF hand transcription factor , kv channel-interacting protein 3 , potassium channel interacting protein 3 , calsenilin, presenilin binding protein, EF hand transcription factor , A-type potassium channel modulating protein 3 , KChIP3 , calsenilin presenilin-binding protein EF hand transcription factor , calsenilin, presenilin-binding protein, EF hand transcription fa , downstream regulatory element-antagonist modulator , Kv channel interacting protein 3, calsenilin

GENE ID SPECIES
30818 Homo sapiens
5568664 Aedes aegypti
6033823 Culex quinquefasciatus
10912880 Trichinella spiralis
56461 Mus musculus
65199 Rattus norvegicus
393755 Danio rerio
459401 Pan troglodytes
513316 Bos taurus
704307 Macaca mulatta
100135241 Xenopus (Silurana) tropicalis
100856050 Canis lupus familiaris
100717101 Cavia porcellus
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