DREAM antibody (N-Term)

Catalog No. ABIN2777506

There is 1 publication for this product available. The Rabbit Polyclonal anti-DREAM antibody is suitable to detect DREAM in samples from Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit, Zebrafish (Danio rerio) and Pig. It has been validated for WB and IHC.

Quick Overview for DREAM antibody (N-Term) (ABIN2777506)

Target: DREAM (KCNIP3) (Kv Channel Interacting Protein 3, Calsenilin (KCNIP3))

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DREAM antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-DREAM Antibody

Binding Specificity: N-Term

Purpose: CSEN Antibody - N-terminal region

Sequence: STVRHQPEGL DQLQAQTKFT KKELQSLYRG FKNECPTGLV DEDTFKLIYA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against CSEN. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CSEN

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8104084

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-DREAM antibody (ABIN2777506)

Fernandes, Ribeiro, Martínez, Orensanz, Barahona, Martínez-Sáenz, Recio, Benedito, Bustamante, Carballido, García-Sacristán, Prieto, Hernández: "Endogenous hydrogen sulfide has a powerful role in inhibitory neurotransmission to the pig bladder neck." in: The Journal of urology, Vol. 189, Issue 4, pp. 1567-73, (2013) (PubMed).

Target Details for DREAM

Target: DREAM (KCNIP3) (Kv Channel Interacting Protein 3, Calsenilin (KCNIP3))

Alternative Name: CSEN

Background:

Background Information: CSEN is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The protein encoded by this gene is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease.

Gene Name: Kv channel interacting protein 3, calsenilin

Alternative Symbols: CSEN, DREAM, KCHIP3

Protein Name: Calsenilin

Molecular Weight: 29kDa

Gene ID: 30818

NCBI Accession: NP_038462

UniProt: Q9Y2W7