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The protein encoded by LIMS1 is an adaptor protein which contains five LIM domains, or double zinc fingers. Additionally we are shipping LIM and Senescent Cell Antigen-Like Domains 1 Proteins (5) and LIM and Senescent Cell Antigen-Like Domains 1 Kits (1) and many more products for this protein.
Showing 10 out of 54 products:
Chicken Monoclonal LIMS1 Primary Antibody for IF, WB - ABIN968921
Campana, Myers, Rearden: Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury. in Glia 2003
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Chicken Monoclonal LIMS1 Primary Antibody for IF, WB - ABIN968920
Tu, Li, Goicoechea, Wu: The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. in Molecular and cellular biology 1999
Show all 3 Pubmed References
Human Monoclonal LIMS1 Primary Antibody for ICC, FACS - ABIN969354
Chiswell, Zhang, Murphy, Boggon, Calderwood: The structural basis of integrin-linked kinase-PINCH interactions. in Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 2 Pubmed References
Human Monoclonal LIMS1 Primary Antibody for FACS, IF - ABIN966832
Yang, Wang, Hawkins, Chen, Vaynberg, Mao, Tu, Zuo, Wang, Wang, Wu, Tjandra, Qin: Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. in The Journal of biological chemistry 2009
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Mammalian cells have two functional PINCH proteins, PINCH1 and PINCH2 (show LIMS2 Antibodies). PINCH not only binds to Nck2 (show NCK2 Antibodies) and engages in the signaling of growth factor receptors, but also forms a ternary complex with ILK (show ILK Antibodies) and parvin (show PARVA Antibodies) (IPP (show IPP Antibodies) complex).
our data suggest an essential role of PINCH1, ILK (show ILK Antibodies) and ILKAP (show ILKAP Antibodies) for the radioresistance of p53 (show TP53 Antibodies)-wildtype glioblastoma multiforme cells
Data suggest that PINCH1 and Nck2 (show NCK2 Antibodies) critically participate in the regulation of cellular radiosensitivity and EGFR (show EGFR Antibodies) function and downstream signaling in a cellular model of human squamous cell carcinoma.
Downregulation of PINCH1 is associated with metastatic breast cancer.
changes in CSF (show CSF2 Antibodies) levels of PINCH appear to correlate with changes in blood CD4 (show CD4 Antibodies) count and with changes in CSF (show CSF2 Antibodies) hyperphosphorylated Tau levels
two novel genes, galectin 9 (show LGALS9 Antibodies) and PINCH, were expressed at much higher levels in cancerous lesions than in normal tissues in all the patients with clear-cell carcinoma who were examined
PINCH predicts survival in rectal cancer patients with RT, but not in patients without RT. The expression of PINCH may be regulated by radiation and by environmental factors surrounding the cells.
PINCH is increased and binds to hp-Tau. These studies address a new mechanism by which AD and HIV may intersect and identify PINCH as a contributing factor to the accumulation of hyperphosphorylated Tau.
Pinch-1 mRNA and protein were significantly up-regulated in acute lymphoblastic leukemia and acute myeloid leukemia (show BCL11A Antibodies) bone marrow stromal cells compared to normal bone marrow stromal cells (p<0.01).
PINCH protein might play an important role in the tumourigenesis and metastasis of gastric adenocarcinoma.
findings suggest that PINCH-1 regulates integrin-mediated adhesion of keratinocytes through the interactions with ILK (show ILK Antibodies) as well as EPLIN (show LIMA1 Antibodies).
Rsu-1 (show RSU1 Antibodies) expression is dramatically decreased in PINCH double knockout mouse livers.
PINCH-1 inhibits JNK (show MAPK8 Antibodies)-mediated apoptosis by stabilising the PINCH-1 binding protein RSU-1 (show RSU1 Antibodies) and promotes Bcl-2 (show BCL2 Antibodies)-dependent pro-survival signalling downstream of integrins.
Data suggest that the adapter protein (show GRB10 Antibodies) PINCH1 critically participates in the regulation of the cellular radiosensitivity of normal and malignant cells similarly under adhesion and suspension conditions.
PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes.
These results provide important evidence for a crucial role of the PINCH-1-ILK (show ILK Antibodies)-alpha-parvin (show PARVA Antibodies) complex in the control of podocyte adhesion, morphology, and survival.
LIM (show PDLIM5 Antibodies) 5 domain of PINCH1 interacts with Rsu-1 (show RSU1 Antibodies) in mammalian cells and functions, in part, by altering cell adhesion.
The PINCH1 is composed of 5 LIM domains, binds ILK and locates to integrin-mediated adhesion sites, and PINCH1 is for integrin function, actin organization, cell-cell adhesion and endodermal cell survival during the implanting of mouse embryos.
PICH1, Ilk (show ILK Antibodies) and alpha-parvin (show PARVA Antibodies) form a complex to costameres in neonatal mouse ventricular myocytes. This complex is stimulated by fibronectins and phenylephrine, and by both by drug synergism, to regulate cardiac myocyte hypertrophy.
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
LIM and senescent cell antigen-like-containing domain protein 1
, particularly interesting new Cys-His protein 1
, renal carcinoma antigen NY-REN-48