anti-Lactate Dehydrogenase A (LDHA) Antibodies

The protein encoded by LDHA catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis.

list all antibodies Gene Name GeneID UniProt
Anti-Human LDHA LDHA 3939 P00338
Anti-Mouse LDHA LDHA 16828 P06151
Anti-Rat LDHA LDHA 24533 P04642
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Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Host: Rabbit Target Name: LDHA Sample Tissue: Human Jurkat, MCF7, 721_B Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: LDHA Sample Type: Hela Antibody Dilution: 1.0ug/ml  LDHA is supported by BioGPS gene expression data to be expressed in HeLa 100 μL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-Ldha Antibody Titration: 1.0 ug/ml Positive Control: Rat Stomach 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image LDHA antibody detects LDHA protein at cytoplasm by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: LDHA protein stained by LDHA antibody , diluted at 1:1000. Red: phalloidin, a cytoskeleton marker, stained by phalloidin (invitrogen, A12380) diluted at 1:200. Blue: Hoechst 33342 staining. WB Image LDHA antibody detects LDHA protein by western blot analysis. Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with LDHA antibody , diluted at 1:1000. 100 μL Log in to see 1 to 2 Days
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometry analysis of Hela cells using LDHA Antibody (Center) Cat.-No AP52459PU-N (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human skin tissue reacted with LDHA Antibody (Center) Cat.-No AP52459PU-N which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 0.4 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated FACS, IHC, WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IF, IHC, WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IF, IHC (p), WB LDHA Antibody (C-term) (ABIN657465) western blot analysis in MDA-MB231 cell line lysates (35 µg/lane). This demonstrates the LDHA antibody detected the LDHA protein (arrow). 400 μL Log in to see 10 to 11 Days
Human Mouse Un-conjugated EIA, IF, WB 0.1 mL Log in to see 6 to 8 Days
Rabbit Goat Un-conjugated EIA, IF, IP, WB Figure 1. Western blot analysis shows anti-Lactate Dehydrogenase antibody detects LDH in HeLa cell extracts. Reactivity with LDH is observed in the cytoplasmic fraction (CF) and little to no reactivity in the nuclear fraction (NF). ~30 µg was loaded per lane onto a 10% gel for SDS-PAGE. Comparison to a molecular weight marker (not shown) indicates a single band of ~36 kDa corresponding to the expected molecular weight for the protein. The blot was incubated with a 1:1,000 dilution of the antibody in 5% milk in TBST at room temperature followed by detection using standard procedures. 2 mL Log in to see 6 to 8 Days

Top referenced anti-Lactate Dehydrogenase A Antibodies

  1. Human Polyclonal Lactate Dehydrogenase A Primary Antibody for ICC, IF - ABIN4329691 : Adochite, Moshnikova, Carlin, Guerrieri, Andreev, Lewis, Reshetnyak: Targeting breast tumors with pH (low) insertion peptides. in Molecular pharmaceutics 2014 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal Lactate Dehydrogenase A Primary Antibody for ICC, IF - ABIN4329689 : Pizzuto, Paventi, Porcile, Sarnataro, Daniele, Passarella et al.: l-Lactate metabolism in HEP G2 cell mitochondria due to the l-lactate dehydrogenase determines the occurrence of the lactate/pyruvate shuttle and the appearance of oxaloacetate, malate and citrate ... in Biochimica et biophysica acta 2012 (PubMed)
    Show all 2 Pubmed References

  3. Cow (Bovine) Polyclonal Lactate Dehydrogenase A Primary Antibody for IHC, WB - ABIN2774085 : Listerman, Bledau, Grishina, Neugebauer: Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. in PLoS genetics 2008 (PubMed)

More Antibodies against Lactate Dehydrogenase A Interaction Partners

Human Lactate Dehydrogenase A (LDHA) interaction partners

  1. LDHA siRNA can inhibit cell proliferation, induce apoptosis, reduce invasion and migration in renal cell carcinoma (show MOK Antibodies) cells.

  2. JMJD2A (show KDM4A Antibodies) regulated aerobic glycolysis by regulating LDHA expression. Therefore, the novel JMJD2A (show KDM4A Antibodies)-LDHA signaling pathway could contribute to the Warburg effects in NPC (show NPC1 Antibodies) progression.

  3. The present study proved that HIF1 (show HIF1A Antibodies)/2alpha could activate LDHA expression in human pancreatic cancer cells, and high expression of LDHA promoted the growth and migration of pancreatic cancer cells.

  4. Pretreatment LDH levels had noticeable prognostic value in advanced pancreatic ductal adenocarcinoma (PDAC) patients who received subsequent chemotherapy. Tackling elevated LDH levels before the initiation of chemotherapy might be a promising measure for improving overall survival of patients after treatment for their advanced PDAC.

  5. Authors demonstrated that knock down of LDHA with siRNA or inhibition of LDHA activity with a LDHA specific inhibitor (FX-11), could sensitize PC-3RR cells to radiotherapy with reduced epithelial-mesenchymal transition, hypoxia, DNA repair ability and autophagy, as well as increased DNA double strand breaks and apoptosis.

  6. Taken together, these results indicate that miR (show MLXIP Antibodies)-142-3p could act as a tumor suppressor in HCC (show FAM126A Antibodies) by targeting LDHA, suggesting new therapeutic targets for HCC (show FAM126A Antibodies) treatment.

  7. Findings suggest that miR (show MLXIP Antibodies)-34b-3 and miR (show MLXIP Antibodies)-449a suppress the development of nasopharyngeal carcinoma (NPC (show NPC1 Antibodies)) through regulation of glycolysis via targeting lactate dehydrogenase A.(LDHA) and may be potential therapeutic targets for the treatment of NPC (show NPC1 Antibodies).

  8. Results provide evidence that miR (show MLXIP Antibodies)-200b acts as a tumor suppressor in glioma through the inhibition of LDHA both in vitro and in vivo.

  9. our data demonstrate that overexpression of 14-3-3zeta (show YWHAZ Antibodies) in early stage pre-cancerous breast epithelial cells may trigger an elevated glycolysis and transcriptionally up-regulating LDHA, thereby contributes to human breast cancer initiation.

  10. serum lactate dehydrogenase has a role in predicting the outcome of resected gastric cancer and construct prognostic nomograms for risk prediction

Rabbit Lactate Dehydrogenase A (LDHA) interaction partners

  1. Dynamic changes of LDH and HBDH activities may be useful in diagnosis of non-thermal low voltage electrical injury and in estimation of post injury intervals.

Mouse (Murine) Lactate Dehydrogenase A (LDHA) interaction partners

  1. Hair follicle stem cells maintain a metabolic state that allows them to remain dormant and yet quickly respond to appropriate proliferative stimuli mediated by LDH-A signaling.

  2. Results revealed that beta-arrestin-1 (show ARRB1 Antibodies) regulates lactate metabolism to contribute to beta2-adrenergic receptor (show ADRB2 Antibodies) functions in improved memory formation.

  3. The authors identified lactate dehydrogenase (LDH) as a new functional target of AMPKalpha1.

  4. LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and natural killer cells.

  5. lactate dehydrogenase A (LDHA) is induced in activated T cells to support aerobic glycolysis but promotes IFN-gamma (show IFNG Antibodies) expression independently of its 3'UTR (show UTS2R Antibodies).

  6. LDHA is a direct target of miR (show MLXIP Antibodies)-34a in regulating glucose metabolism and tumor growth in breast cancer.

  7. Findings suggest that RANKL protein-induced lactate dehydrogenase (LDH) activation stimulates glycolytic and mitochondrial respiratory metabolism via transcription factor NFATc1 signaling.

  8. We propose a profibrotic feed forward loop, in which radiation induces LDHA expression and lactate production, which can lead to further activation of TGF-beta (show TGFB1 Antibodies) to drive the fibrotic process.

  9. High LDH-A expression is associated with metastases in breast tumors.

  10. PGC-1alpha reduces the expression of LDH A and one of its regulators, the transcription factor myelocytomatosis oncogene (show MYC Antibodies).

Pig (Porcine) Lactate Dehydrogenase A (LDHA) interaction partners

  1. These findings indicated that heat shock (HS)-induced autophagy regulates lactate secretion by inhibiting apoptosis and increasing mRNA transcript and protein levels of SLC2A3 (show SLC2A3 Antibodies), LDHA, and SLC16A1 (show SLC16A1 Antibodies), which suggests that HS-induced autophagy may enhance lactate secretion by sertoli cells.

  2. The NADH-cofactor binding site of pig heart LDH is involved in the interaction with acidic phospholipids, in the pig skeletal muscle LDH, neither the cofactor binding site nor the subunit interfacing areas seem to be involved in the interaction.

  3. Both LDHA and COPB1 (show COPB1 Antibodies) were highly expressed in porcine skeletal muscle tissues, implying their potential regulatory function of muscle development.

Horse (Equine) Lactate Dehydrogenase A (LDHA) interaction partners

  1. Molecular characterization and expression pattern of the equine lactate dehydrogenase A genes

Lactate Dehydrogenase A (LDHA) Antigen Profile

Protein Summary

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene.

Gene names and symbols associated with LDHA

  • lactate dehydrogenase A (LDHA) antibody
  • lactate dehydrogenase B L homeolog (ldhb.L) antibody
  • lactate dehydrogenase A (Ldha) antibody
  • lactate dehydrogenase A4 (ldha) antibody
  • lactate dehydrogenase A (ldha) antibody
  • lactate dehydrogenase A L homeolog (ldha.L) antibody
  • L-lactate dehydrogenase A chain (LOC100713875) antibody
  • gsd11 antibody
  • l7R2 antibody
  • LDH-A antibody
  • ldh-h antibody
  • ldh-m antibody
  • ldh1 antibody
  • ldha antibody
  • ldha-B antibody
  • ldha1 antibody
  • ldhab antibody
  • ldhbb antibody
  • LDHC antibody
  • ldhm antibody
  • pig19 antibody
  • trg-5 antibody

Protein level used designations for LDHA

L-lactate dehydrogenase A chain , LDH muscle subunit , LDH-A , LDH-M , cell proliferation-inducing gene 19 protein , lactate dehydrogenase M , proliferation-inducing gene 19 , renal carcinoma antigen NY-REN-59 , lactate dehydrogenase-M , lactate dehydrogenase A , M-LDH , lactate dehydrogenase 1, A chain , lactate dehydrogenase A4 , lactate dehydrogenase-A , lactate dehydrogenase A-like , ldha1 , lactate dehydrogenase A1 , lactate dehydrogenase C , L-lactic acid dehydrogenase , upsilon-crystallin , M(A)-type lactate dehydrogenase

3939 Homo sapiens
100009107 Oryctolagus cuniculus
394355 Xenopus laevis
16828 Mus musculus
24533 Rattus norvegicus
30496 Danio rerio
281274 Bos taurus
394758 Xenopus (Silurana) tropicalis
396221 Gallus gallus
398121 Xenopus laevis
407245 Sus scrofa
451063 Pan troglodytes
476882 Canis lupus familiaris
503513 Monodelphis domestica
791112 Ornithorhynchus anatinus
100057016 Equus caballus
100173786 Pongo abelii
100713875 Cavia porcellus
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