anti-Lactate Dehydrogenase A (LDHA) Antibodies

The protein encoded by LDHA catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. Additionally we are shipping Lactate Dehydrogenase A Proteins (56) and Lactate Dehydrogenase A Kits (20) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LDHA 3939 P00338
LDHA 16828 P06151
LDHA 24533 P04642
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Top anti-Lactate Dehydrogenase A Antibodies at antibodies-online.com

Showing 10 out of 260 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Host: Rabbit Target Name: LDHA Sample Tissue: Human Jurkat, MCF7, 721_B Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: LDHA Sample Type: Hela Antibody Dilution: 1.0ug/ml  LDHA is supported by BioGPS gene expression data to be expressed in HeLa 100 μL 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Ldha Antibody Titration: 1.0 ug/ml Positive Control: Rat Stomach 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated IHC (p), WB LDHA was detected in paraffin-embedded sections of human mammary cancer tissues using rabbit anti- LDHA Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). LDHA was detected in paraffin-embedded sections of mouse intestine tissues using rabbit anti- LDHA Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). 100 μg 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image LDHA antibody detects LDHA protein at cytoplasm by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: LDHA protein stained by LDHA antibody , diluted at 1:1000. Red: phalloidin, a cytoskeleton marker, stained by phalloidin (invitrogen, A12380) diluted at 1:200. Blue: Hoechst 33342 staining. WB Image LDHA antibody detects LDHA protein by western blot analysis. Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with LDHA antibody , diluted at 1:1000. 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometry analysis of Hela cells using LDHA Antibody (Center) Cat.-No AP52459PU-N (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human skin tissue reacted with LDHA Antibody (Center) Cat.-No AP52459PU-N which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IF, IHC, WB 100 μL 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated FACS, IHC, WB 100 μL 2 to 3 Days
$245.00
Details
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6269762 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6269762 at 1/100 staining rat heart tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$450.00
Details

Top referenced anti-Lactate Dehydrogenase A Antibodies

  1. Human Polyclonal Lactate Dehydrogenase A Primary Antibody for ICC, IF - ABIN4329691 : Adochite, Moshnikova, Carlin, Guerrieri, Andreev, Lewis, Reshetnyak: Targeting breast tumors with pH (low) insertion peptides. in Molecular pharmaceutics 2014 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal Lactate Dehydrogenase A Primary Antibody for ELISA, IHC - ABIN6262941 : Xiao, Huang, Ye, Chen, Song, Wen, Zhang, Zheng, Tang, Xie: The miR-34a-LDHA axis regulates glucose metabolism and tumor growth in breast cancer. in Scientific reports 2016 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal Lactate Dehydrogenase A Primary Antibody for ELISA, WB - ABIN534437 : Mdluli, Booth, Brady, Rumsby: A preliminary account of the properties of recombinant human Glyoxylate reductase (GRHPR), LDHA and LDHB with glyoxylate, and their potential roles in its metabolism. in Biochimica et biophysica acta 2005 (PubMed)
    Show all 3 Pubmed References

  4. Human Monoclonal Lactate Dehydrogenase A Primary Antibody for IP, ELISA - ABIN534438 : Giatromanolaki, Koukourakis, Pezzella, Sivridis, Turley, Harris, Gatter: Lactate dehydrogenase 5 expression in non-Hodgkin B-cell lymphomas is associated with hypoxia regulated proteins. in Leukemia & lymphoma 2008 (PubMed)
    Show all 3 Pubmed References

  5. Human Monoclonal Lactate Dehydrogenase A Primary Antibody for ICC, IF - ABIN4329689 : Pizzuto, Paventi, Porcile, Sarnataro, Daniele, Passarella et al.: l-Lactate metabolism in HEP G2 cell mitochondria due to the l-lactate dehydrogenase determines the occurrence of the lactate/pyruvate shuttle and the appearance of oxaloacetate, malate and citrate ... in Biochimica et biophysica acta 2012 (PubMed)
    Show all 2 Pubmed References

  6. Cow (Bovine) Polyclonal Lactate Dehydrogenase A Primary Antibody for IHC, WB - ABIN2774085 : Listerman, Bledau, Grishina, Neugebauer: Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. in PLoS genetics 2008 (PubMed)
    Show all 2 Pubmed References

  7. Mouse (Murine) Polyclonal Lactate Dehydrogenase A Primary Antibody for IHC, WB - ABIN3021545 : Xu, Liu, Zha, Fan, Zhang, Li, Xiao: A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein. in PLoS pathogens 2019 (PubMed)

  8. Human Polyclonal Lactate Dehydrogenase A Primary Antibody for ICC, IF - ABIN4329714 : Boyle, Patronas, Smirniotopoulos, Herscovitch, Dieckman, Millo, Maric, Chatain, Hayes, Benzo, Scott, Edwards, Ray Chaudhury, Lodish, Sharma, Nieman, Stratakis, Lonser, Chittiboina: CRH stimulation improves 18F-FDG-PET detection of pituitary adenomas in Cushing's disease. in Endocrine 2019 (PubMed)

More Antibodies against Lactate Dehydrogenase A Interaction Partners

Human Lactate Dehydrogenase A (LDHA) interaction partners

  1. 14-3-3eta inhibits LDHA by direct interaction in the setting of complex I dysfunction, highlighting the role of 14-3-3eta overexpression and inefficient oxidative phosphorylation in oncocytoma mitochondrial biogenesis.

  2. Results indicate that LDHA modulates autophagy by interacting with Beclin-1 in tamoxifen resistant breast cancer cells. Further data confirmed the association of LDHA in apoptosis resistance, increasing of EMT like phenomena and augmented pro-survival autophagy leading to the enhanced survivability of tamoxifen-resistant breast cancer.

  3. we demonstrate here that inhibition with siRNA against the glycolytic genes PFKFB3 or LDHA, respectively, prevents the proliferation of HUVECs and inhibits vessel formation in vitro as well as in vivo.

  4. LDHA inhibition fails to impact human melanoma cell proliferation, survival, or tumor growth. Reduced intracellular serine and aspartate following LDHA inhibition engage GCN2-ATF4 signaling to initiate an expansive pro-survival response.

  5. Our results indicate that ectopic FGFR1 expression reprograms the energy metabolism of prostate cancer cells, representing a hallmark change in prostate cancer progression. FGF signaling drives the Warburg effect through differential regulation of LDHA and LDHB, thereby promoting the progression of prostate cancer

  6. In patients treated with ipilimumab and nivolumab, baseline S100B and increasing S100B levels of >145% as well as baseline LDH were associated with impaired overall survival (OS) whereas increasing LDH of >25% was not (P = .64). S100B could serve as a strong baseline marker for OS in melanoma patients receiving anti-PD-1 therapy.

  7. Knockdown of LDHA by siRNA inhibits the migration and invasion via downregulation of glycolysis in ErbB2 over expressing breast cancer cell line

  8. the present study reports that the combination of tumour stroma percentage and tumour cell expression of cytoplasmic MCT-2 or nuclear LDH-5 is associated with poor prognosis.

  9. Serum LDH levels at baseline before nivolumab treatment were associated with the objective response and clinical outcome of nivolumab treatment

  10. LDHA promotes malignant behavior via activation of epithelial-to-mesenchymal transition in lung adenocarcinoma.

  11. Knockout of both LDH-A and LDH-B leads to suppression of glycolysis.

  12. LDHA and LDHB are dispensable for aerobic glycolysis in neuroblastoma cells while promoting their aggressiveness.

  13. Oligometastatic disease is not always correctly diagnosed, because all radiological modalities are limited by certain thresholds for detection of small metastases. We hypothesize that LDH is associated with survival, because this biomarker may reflect the total burden of malignant disease.

  14. Repression of LDHA induced by wt-p53 blocks tumor growth and invasion through downregulation of aerobic glycolysis in breast cancer.

  15. Data show that the 3'-untranslated region (3'-UTR) of LDHA mRNA was the direct target of microRNA-30d-5p (miR-30d-5p), which was low expressed in gallbladder cancer (GBC) tissues and associated with poor prognosis of GBC patients.

  16. e evaluated the link between mTOR kinase activity and the level of LDH expression / function. Furthermore, we elaborated the metabolic changes produced in cells by the mTOR-directed LDH-A up-regulation. Interestingly, we observed that in the non-neoplastic MCF-10A culture, mTOR-directed up-regulation of LDH-A was followed by a reprogramming of cell metabolism, which showed an increased dependence on glycolysis rather tha

  17. Tumor LDH-A expression, serum LDH status, and the slope of serum LDH status were closely associated with triple negative breast cancer brain metastasis and brain metastasis free survival. This study indicates that tumor LDH and serum LDH status are two predictors for triple negative breast cancer brain metastasis.

  18. Study revealed that LDHA expression was dysregulated in invasive pituitary adenoma (PA). In addition, LDHA was demonstrated to play an important role in invasion as well as PA growth.

  19. The study reveals that miR-33b plays a suppressive role in the regulation of osteosarcoma cell proliferation through direct targeting LDHA.

  20. hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.

Rabbit Lactate Dehydrogenase A (LDHA) interaction partners

  1. Dynamic changes of LDH and HBDH activities may be useful in diagnosis of non-thermal low voltage electrical injury and in estimation of post injury intervals.

Mouse (Murine) Lactate Dehydrogenase A (LDHA) interaction partners

  1. the LDHA protein level was remarkably decreased in Ldhc-deficient sperm, indicating that LDHC is required for LDHA expression in the sperm.

  2. LDH-A depletion inhibits the formation of metastases and prolongs survival through changes in mammary tumor microenvironment that modulate the immune response. We attribute these effects to diminished HIF-1a activity, vascularization, necrosis formation and immune suppression in immune competent animals.

  3. The release of lactate dehydrogenase A (LDHA) from degenerating neurons drives central nervous system (CNS) angiogenesis.

  4. Hair follicle stem cells maintain a metabolic state that allows them to remain dormant and yet quickly respond to appropriate proliferative stimuli mediated by LDH-A signaling.

  5. Results revealed that beta-arrestin-1 regulates lactate metabolism to contribute to beta2-adrenergic receptor functions in improved memory formation.

  6. The authors identified lactate dehydrogenase (LDH) as a new functional target of AMPKalpha1.

  7. LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and natural killer cells.

  8. lactate dehydrogenase A (LDHA) is induced in activated T cells to support aerobic glycolysis but promotes IFN-gamma expression independently of its 3'UTR.

  9. LDHA is a direct target of miR-34a in regulating glucose metabolism and tumor growth in breast cancer.

  10. Findings suggest that RANKL protein-induced lactate dehydrogenase (LDH) activation stimulates glycolytic and mitochondrial respiratory metabolism via transcription factor NFATc1 signaling.

  11. We propose a profibrotic feed forward loop, in which radiation induces LDHA expression and lactate production, which can lead to further activation of TGF-beta to drive the fibrotic process.

  12. High LDH-A expression is associated with metastases in breast tumors.

  13. PGC-1alpha reduces the expression of LDH A and one of its regulators, the transcription factor myelocytomatosis oncogene.

  14. Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer.

  15. Down-regulation of expression of stress-activated genes PKC-alpha, c-Myc and LDH-A by alpha-tocopherol in cancerous mice.

  16. The cumulus cells and oocytes showed intense signals for lactate dehydrogenase (LDH)-A respectively.

  17. isoproterenol induces changes in gastrocnemius muscle and serum lactate dehydrogenase expression in mice

  18. Cocaine could inhibit the activities of ATPase, LDH and SDH in cultured splenocytes.

  19. The increased LDH-A/LDH-B ratio causes high brain lactate levels, which, in turn, are predictive of aging phenotypes.

  20. The muscle subunit of lactate dehydrogenase is an integral part of the sarcolemmal K(ATP) channel complex in vivo, where it couples the metabolic status of the cell with the K(ATP) channel activity essential for protection against ischemia.

Pig (Porcine) Lactate Dehydrogenase A (LDHA) interaction partners

  1. These findings indicated that heat shock (HS)-induced autophagy regulates lactate secretion by inhibiting apoptosis and increasing mRNA transcript and protein levels of SLC2A3, LDHA, and SLC16A1, which suggests that HS-induced autophagy may enhance lactate secretion by sertoli cells.

  2. The NADH-cofactor binding site of pig heart LDH is involved in the interaction with acidic phospholipids, in the pig skeletal muscle LDH, neither the cofactor binding site nor the subunit interfacing areas seem to be involved in the interaction.

  3. Both LDHA and COPB1 were highly expressed in porcine skeletal muscle tissues, implying their potential regulatory function of muscle development.

Horse (Equine) Lactate Dehydrogenase A (LDHA) interaction partners

  1. Molecular characterization and expression pattern of the equine lactate dehydrogenase A genes

Lactate Dehydrogenase A (LDHA) Antigen Profile

Protein Summary

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene.

Gene names and symbols associated with LDHA

  • lactate dehydrogenase A (LDHA) antibody
  • lactate dehydrogenase B L homeolog (ldhb.L) antibody
  • lactate dehydrogenase A (Ldha) antibody
  • lactate dehydrogenase A4 (ldha) antibody
  • lactate dehydrogenase A (ldha) antibody
  • lactate dehydrogenase A L homeolog (ldha.L) antibody
  • L-lactate dehydrogenase A chain (LOC100713875) antibody
  • gsd11 antibody
  • l7R2 antibody
  • LDH-A antibody
  • ldh-h antibody
  • ldh-m antibody
  • ldh1 antibody
  • ldha antibody
  • ldha-B antibody
  • ldha1 antibody
  • ldhab antibody
  • ldhbb antibody
  • LDHC antibody
  • ldhm antibody
  • pig19 antibody
  • trg-5 antibody

Protein level used designations for LDHA

L-lactate dehydrogenase A chain , LDH muscle subunit , LDH-A , LDH-M , cell proliferation-inducing gene 19 protein , lactate dehydrogenase M , proliferation-inducing gene 19 , renal carcinoma antigen NY-REN-59 , lactate dehydrogenase-M , lactate dehydrogenase A , M-LDH , lactate dehydrogenase 1, A chain , lactate dehydrogenase A4 , lactate dehydrogenase-A , lactate dehydrogenase A-like , ldha1 , lactate dehydrogenase A1 , lactate dehydrogenase C , L-lactic acid dehydrogenase , upsilon-crystallin , M(A)-type lactate dehydrogenase

GENE ID SPECIES
3939 Homo sapiens
100009107 Oryctolagus cuniculus
394355 Xenopus laevis
16828 Mus musculus
24533 Rattus norvegicus
30496 Danio rerio
281274 Bos taurus
394758 Xenopus (Silurana) tropicalis
396221 Gallus gallus
398121 Xenopus laevis
407245 Sus scrofa
451063 Pan troglodytes
476882 Canis lupus familiaris
503513 Monodelphis domestica
791112 Ornithorhynchus anatinus
100057016 Equus caballus
100173786 Pongo abelii
100713875 Cavia porcellus
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