anti-Lactate Dehydrogenase A (LDHA) Antibodies

The protein encoded by LDHA catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. Additionally we are shipping Lactate Dehydrogenase A Proteins (58) and Lactate Dehydrogenase A Kits (42) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LDHA 3939 P00338
LDHA 16828 P06151
LDHA 24533 P04642
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Top anti-Lactate Dehydrogenase A Antibodies at antibodies-online.com

Showing 10 out of 276 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Host: Rabbit Target Name: LDHA Sample Tissue: Human Jurkat, MCF7, 721_B Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: LDHA Sample Type: Hela Antibody Dilution: 1.0ug/ml  LDHA is supported by BioGPS gene expression data to be expressed in HeLa 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Ldha Antibody Titration: 1.0 ug/ml Positive Control: Rat Stomach 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated IHC (p), WB LDHA was detected in paraffin-embedded sections of human mammary cancer tissues using rabbit anti- LDHA Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). LDHA was detected in paraffin-embedded sections of mouse intestine tissues using rabbit anti- LDHA Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image LDHA antibody detects LDHA protein at cytoplasm by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: LDHA protein stained by LDHA antibody , diluted at 1:1000. Red: phalloidin, a cytoskeleton marker, stained by phalloidin (invitrogen, A12380) diluted at 1:200. Blue: Hoechst 33342 staining. WB Image LDHA antibody detects LDHA protein by western blot analysis. Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with LDHA antibody , diluted at 1:1000. 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometry analysis of Hela cells using LDHA Antibody (Center) Cat.-No AP52459PU-N (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human skin tissue reacted with LDHA Antibody (Center) Cat.-No AP52459PU-N which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (fro), IHC (p), SimWes, WB Western Blot: Lactate Dehydrogenase A/LDHA Antibody [NBP1-48336] - Analysis of Lactate Dehydrogenase A in HeLa whole cell lysates. Western Blot: Lactate Dehydrogenase A/LDHA Antibody [NBP1-48336] - Analysis of Lactate Dehydrogenase A in NIH/3T3 whole cell lysates. 0.1 mL Log in to see 7 to 9 Days
$446.35
Details
Human Rabbit Un-conjugated FACS, IHC, WB 100 μL Log in to see 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated IF, IHC, WB 100 μL Log in to see 2 to 3 Days
$245.00
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$429.84
Details

Top referenced anti-Lactate Dehydrogenase A Antibodies

  1. Human Polyclonal Lactate Dehydrogenase A Primary Antibody for ICC, IF - ABIN4329691 : Adochite, Moshnikova, Carlin, Guerrieri, Andreev, Lewis, Reshetnyak: Targeting breast tumors with pH (low) insertion peptides. in Molecular pharmaceutics 2014 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal Lactate Dehydrogenase A Primary Antibody for ELISA, IHC - ABIN6262941 : Xiao, Huang, Ye, Chen, Song, Wen, Zhang, Zheng, Tang, Xie: The miR-34a-LDHA axis regulates glucose metabolism and tumor growth in breast cancer. in Scientific reports 2016 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal Lactate Dehydrogenase A Primary Antibody for IP, ELISA - ABIN534438 : Mdluli, Booth, Brady, Rumsby: A preliminary account of the properties of recombinant human Glyoxylate reductase (GRHPR), LDHA and LDHB with glyoxylate, and their potential roles in its metabolism. in Biochimica et biophysica acta 2005 (PubMed)
    Show all 3 Pubmed References

  4. Human Monoclonal Lactate Dehydrogenase A Primary Antibody for ELISA, WB - ABIN534437 : Giatromanolaki, Koukourakis, Pezzella, Sivridis, Turley, Harris, Gatter: Lactate dehydrogenase 5 expression in non-Hodgkin B-cell lymphomas is associated with hypoxia regulated proteins. in Leukemia & lymphoma 2008 (PubMed)
    Show all 3 Pubmed References

  5. Human Monoclonal Lactate Dehydrogenase A Primary Antibody for ICC, IF - ABIN4329689 : Pizzuto, Paventi, Porcile, Sarnataro, Daniele, Passarella et al.: l-Lactate metabolism in HEP G2 cell mitochondria due to the l-lactate dehydrogenase determines the occurrence of the lactate/pyruvate shuttle and the appearance of oxaloacetate, malate and citrate ... in Biochimica et biophysica acta 2012 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal Lactate Dehydrogenase A Primary Antibody for FACS, IHC (p) - ABIN653476 : Zhao, Zhou, Liu, Ding, Khong, Yu, Fodstad, Tan: Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth. in Oncogene 2009 (PubMed)
    Show all 2 Pubmed References

  7. Cow (Bovine) Polyclonal Lactate Dehydrogenase A Primary Antibody for IHC, WB - ABIN2774085 : Listerman, Bledau, Grishina, Neugebauer: Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. in PLoS genetics 2008 (PubMed)

  8. Mouse (Murine) Polyclonal Lactate Dehydrogenase A Primary Antibody for IHC, WB - ABIN3021545 : Xu, Liu, Zha, Fan, Zhang, Li, Xiao: A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein. in PLoS pathogens 2019 (PubMed)

More Antibodies against Lactate Dehydrogenase A Interaction Partners

Human Lactate Dehydrogenase A (LDHA) interaction partners

  1. Data show that the 3'-untranslated region (3'-UTR) of LDHA mRNA was the direct target of microRNA-30d-5p (miR-30d-5p), which was low expressed in gallbladder cancer (GBC) tissues and associated with poor prognosis of GBC patients.

  2. e evaluated the link between mTOR kinase activity and the level of LDH expression / function. Furthermore, we elaborated the metabolic changes produced in cells by the mTOR-directed LDH-A up-regulation. Interestingly, we observed that in the non-neoplastic MCF-10A culture, mTOR-directed up-regulation of LDH-A was followed by a reprogramming of cell metabolism, which showed an increased dependence on glycolysis rather tha

  3. Tumor LDH-A expression, serum LDH status, and the slope of serum LDH status were closely associated with triple negative breast cancer brain metastasis and brain metastasis free survival. This study indicates that tumor LDH and serum LDH status are two predictors for triple negative breast cancer brain metastasis.

  4. Study revealed that LDHA expression was dysregulated in invasive pituitary adenoma (PA). In addition, LDHA was demonstrated to play an important role in invasion as well as PA growth.

  5. The study reveals that miR-33b plays a suppressive role in the regulation of osteosarcoma cell proliferation through direct targeting LDHA.

  6. hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.

  7. the results of the present study demonstrated that miR199a3p can inhibit LDHA expression by downregulating Sp1, and provided mechanistic evidence supporting the existence of a novel miR199a3p/Sp1/LDHA axis and its critical contribution to aerobic glycolysis in testicular cancer cells.

  8. High LDHA expression is associated with Non-Small Cell Lung Cancer.

  9. This is the first study from this highly prevalent region of Head neck cancer showing that serum LDH could be regarded as a biomarker for malignant and premalignant conditions of the head and neck.

  10. High LDH expression is associated with small cell lung cancer.

  11. The PFK2 expression along with LDH-4 were observed to be increased ~2-fold (P < 0.001) in 0.5 mM ammonia treated brain slices.

  12. miR-199a-3p is a major metabolic regulator in tumor suppression and miR-199a-3p may downregulate metabolic genes (LDHA, PGK1, MCT1, TIGAR) through the transcription factor Sp1.

  13. The expression of LDH-5 and hypoxia-inducible factor (HIF) 1alpha in Non-Hodgkin's lymphoma, was examined.

  14. Results show that LDHA is highly expressed in triple negative breast cancer (TNBC) and correlated with a poor outcome. Its 3'UTR is targeted by miR-34a. Also, LDHA along with PDL1 seem to act as ceRNAs to promote the expression and function of each other through regulation of miR-34a in TNBC.

  15. LDHA siRNA can inhibit cell proliferation, induce apoptosis, reduce invasion and migration in renal cell carcinoma cells.

  16. JMJD2A regulated aerobic glycolysis by regulating LDHA expression. Therefore, the novel JMJD2A-LDHA signaling pathway could contribute to the Warburg effects in NPC progression.

  17. The present study proved that HIF1/2alpha could activate LDHA expression in human pancreatic cancer cells, and high expression of LDHA promoted the growth and migration of pancreatic cancer cells.

  18. Pretreatment LDH levels had noticeable prognostic value in advanced pancreatic ductal adenocarcinoma (PDAC) patients who received subsequent chemotherapy. Tackling elevated LDH levels before the initiation of chemotherapy might be a promising measure for improving overall survival of patients after treatment for their advanced PDAC.

  19. Authors demonstrated that knock down of LDHA with siRNA or inhibition of LDHA activity with a LDHA specific inhibitor (FX-11), could sensitize PC-3RR cells to radiotherapy with reduced epithelial-mesenchymal transition, hypoxia, DNA repair ability and autophagy, as well as increased DNA double strand breaks and apoptosis.

  20. Taken together, these results indicate that miR-142-3p could act as a tumor suppressor in HCC by targeting LDHA, suggesting new therapeutic targets for HCC treatment.

Rabbit Lactate Dehydrogenase A (LDHA) interaction partners

  1. Dynamic changes of LDH and HBDH activities may be useful in diagnosis of non-thermal low voltage electrical injury and in estimation of post injury intervals.

Mouse (Murine) Lactate Dehydrogenase A (LDHA) interaction partners

  1. The release of lactate dehydrogenase A (LDHA) from degenerating neurons drives central nervous system (CNS) angiogenesis.

  2. Hair follicle stem cells maintain a metabolic state that allows them to remain dormant and yet quickly respond to appropriate proliferative stimuli mediated by LDH-A signaling.

  3. Results revealed that beta-arrestin-1 regulates lactate metabolism to contribute to beta2-adrenergic receptor functions in improved memory formation.

  4. The authors identified lactate dehydrogenase (LDH) as a new functional target of AMPKalpha1.

  5. LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and natural killer cells.

  6. lactate dehydrogenase A (LDHA) is induced in activated T cells to support aerobic glycolysis but promotes IFN-gamma expression independently of its 3'UTR.

  7. LDHA is a direct target of miR-34a in regulating glucose metabolism and tumor growth in breast cancer.

  8. Findings suggest that RANKL protein-induced lactate dehydrogenase (LDH) activation stimulates glycolytic and mitochondrial respiratory metabolism via transcription factor NFATc1 signaling.

  9. We propose a profibrotic feed forward loop, in which radiation induces LDHA expression and lactate production, which can lead to further activation of TGF-beta to drive the fibrotic process.

  10. High LDH-A expression is associated with metastases in breast tumors.

  11. PGC-1alpha reduces the expression of LDH A and one of its regulators, the transcription factor myelocytomatosis oncogene.

  12. Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer.

  13. Down-regulation of expression of stress-activated genes PKC-alpha, c-Myc and LDH-A by alpha-tocopherol in cancerous mice.

  14. The cumulus cells and oocytes showed intense signals for lactate dehydrogenase (LDH)-A respectively.

  15. isoproterenol induces changes in gastrocnemius muscle and serum lactate dehydrogenase expression in mice

  16. Cocaine could inhibit the activities of ATPase, LDH and SDH in cultured splenocytes.

  17. The increased LDH-A/LDH-B ratio causes high brain lactate levels, which, in turn, are predictive of aging phenotypes.

  18. The muscle subunit of lactate dehydrogenase is an integral part of the sarcolemmal K(ATP) channel complex in vivo, where it couples the metabolic status of the cell with the K(ATP) channel activity essential for protection against ischemia.

  19. Reduction in LDH-A activity resulted in stimulation of mitochondrial respiration and decrease of mitochondrial membrane potential. The tumorigenicity of the LDH-A-deficient cells was severely diminished.

  20. beta-agonists increased serum LDH levels, but it was not due to release from the heart.

Pig (Porcine) Lactate Dehydrogenase A (LDHA) interaction partners

  1. These findings indicated that heat shock (HS)-induced autophagy regulates lactate secretion by inhibiting apoptosis and increasing mRNA transcript and protein levels of SLC2A3, LDHA, and SLC16A1, which suggests that HS-induced autophagy may enhance lactate secretion by sertoli cells.

  2. The NADH-cofactor binding site of pig heart LDH is involved in the interaction with acidic phospholipids, in the pig skeletal muscle LDH, neither the cofactor binding site nor the subunit interfacing areas seem to be involved in the interaction.

  3. Both LDHA and COPB1 were highly expressed in porcine skeletal muscle tissues, implying their potential regulatory function of muscle development.

Horse (Equine) Lactate Dehydrogenase A (LDHA) interaction partners

  1. Molecular characterization and expression pattern of the equine lactate dehydrogenase A genes

Lactate Dehydrogenase A (LDHA) Antigen Profile

Protein Summary

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene.

Gene names and symbols associated with LDHA

  • lactate dehydrogenase A (LDHA) antibody
  • lactate dehydrogenase B L homeolog (ldhb.L) antibody
  • lactate dehydrogenase A (Ldha) antibody
  • lactate dehydrogenase A4 (ldha) antibody
  • lactate dehydrogenase A (ldha) antibody
  • lactate dehydrogenase A L homeolog (ldha.L) antibody
  • L-lactate dehydrogenase A chain (LOC100713875) antibody
  • gsd11 antibody
  • l7R2 antibody
  • LDH-A antibody
  • ldh-h antibody
  • ldh-m antibody
  • ldh1 antibody
  • ldha antibody
  • ldha-B antibody
  • ldha1 antibody
  • ldhab antibody
  • ldhbb antibody
  • LDHC antibody
  • ldhm antibody
  • pig19 antibody
  • trg-5 antibody

Protein level used designations for LDHA

L-lactate dehydrogenase A chain , LDH muscle subunit , LDH-A , LDH-M , cell proliferation-inducing gene 19 protein , lactate dehydrogenase M , proliferation-inducing gene 19 , renal carcinoma antigen NY-REN-59 , lactate dehydrogenase-M , lactate dehydrogenase A , M-LDH , lactate dehydrogenase 1, A chain , lactate dehydrogenase A4 , lactate dehydrogenase-A , lactate dehydrogenase A-like , ldha1 , lactate dehydrogenase A1 , lactate dehydrogenase C , L-lactic acid dehydrogenase , upsilon-crystallin , M(A)-type lactate dehydrogenase

GENE ID SPECIES
3939 Homo sapiens
100009107 Oryctolagus cuniculus
394355 Xenopus laevis
16828 Mus musculus
24533 Rattus norvegicus
30496 Danio rerio
281274 Bos taurus
394758 Xenopus (Silurana) tropicalis
396221 Gallus gallus
398121 Xenopus laevis
407245 Sus scrofa
451063 Pan troglodytes
476882 Canis lupus familiaris
503513 Monodelphis domestica
791112 Ornithorhynchus anatinus
100057016 Equus caballus
100173786 Pongo abelii
100713875 Cavia porcellus
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