Like-Glycosyltransferase (LARGE) ELISA Kits

LARGE, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. Additionally we are shipping Like-Glycosyltransferase Antibodies (45) and Like-Glycosyltransferase Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
LARGE 9215 O95461
LARGE 16795 Q9Z1M7
Anti-Rat LARGE LARGE 361368  
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Top Like-Glycosyltransferase ELISA Kits at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details
Mouse
  96 Tests Log in to see 15 to 18 Days
$875.60
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Chicken
  96 Tests Log in to see 15 to 18 Days
$1,095.60
Details

More ELISA Kits for Like-Glycosyltransferase Interaction Partners

Human Like-Glycosyltransferase (LARGE) interaction partners

  1. This study suggests LARGE as the first known modifier of plasma antithrombin (show SERPINC1 ELISA Kits).

  2. results reveal that the LARGE-glycan of dystroglycan serves as a tunable extracellular matrix protein scaffold, the extension of which is required for normal skeletal muscle function

  3. LARGE could act as a bifunctional glycosyltransferase, with xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-alpha1,3-glucuronic acid-beta1-]; allowed alpha-DG to bind laminin-G domain-containing ECM (show MMRN1 ELISA Kits) ligands

  4. the ligand-binding activity of alpha-dystroglycan is conferred primarily by LARGE modification at Thr (show TRH ELISA Kits)-317 and -319, within the highly conserved first 18 amino acids of the mucin (show SLC13A2 ELISA Kits)-like domain

  5. LARGE2 was found to support the maturation of alpha-dystroglycan more effectively than LARGE.

  6. LARGE repression is responsible for the defects in dystroglycan-mediated cell adhesion that are observed in epithelium-derived cancer cells and point to a defect of dystroglycan glycosylation as a factor in cancer progression

Mouse (Murine) Like-Glycosyltransferase (LARGE) interaction partners

  1. data suggest LARGE overexpression may only be deleterious under a forced regenerative context, such as that resulting from a reduction in FKRP (show FKRP ELISA Kits): in the absence of such a defect we show that systemic expression of LARGE can indeed act therapeutically, and that even dramatic LARGE overexpression is well-tolerated in heart and skeletal muscle

  2. MBP1 (show ENO1 ELISA Kits) inhibits Ab fibril formation in vitro and demonstrate the ability of MBP1 (show ENO1 ELISA Kits) to reduce Ab pathology and improve behavioral performance.

  3. The overexpression of LARGE aggravates muscular dystrophy by suppressing the muscle regeneration and this adverse effect is mediated via reduced expression of IGF-1 (show IGF1 ELISA Kits).

  4. Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of alpha-dystroglycan in cells and tissues.

  5. The overexpression of LARGE leads to a shortened lifespan and worsening of the FKRP (show FKRP ELISA Kits)-MD phenotype

  6. blocking Large during muscle regeneration results in synthesis of dystroglycan with minimal LARGE-glycan repeats in association with less compact basement membrane, immature neuromuscular junctions, and dysfunctional muscle predisposed to dystrophy

  7. Muscular dystrophy defects are primarily due to the effects of LARGE and glycosylated dystroglycan in stabilizing the endplate of the neuromuscular junction.

  8. LARGE could act as a bifunctional glycosyltransferase, with xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-alpha1,3-glucuronic acid-beta1-]; allowed alpha-DG to bind laminin-G domain-containing ECM (show MMRN1 ELISA Kits) ligands

  9. Differential glycosylation of alpha-dystroglycan and proteins other than alpha-dystroglycan by like-glycosyltransferase.

  10. a mechanism by which Large competes with galactosyltransferase to target GlcNAc terminals to induce the functional glycans on alpha-DG

Like-Glycosyltransferase (LARGE) Antigen Profile

Antigen Summary

This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Gene names and symbols associated with LARGE

  • LARGE xylosyl- and glucuronyltransferase 1 L homeolog (large1.L) antibody
  • LARGE xylosyl- and glucuronyltransferase 1 (LARGE1) antibody
  • LARGE xylosyl- and glucuronyltransferase 1 (Large1) antibody
  • LARGE xylosyl- and glucuronyltransferase 1 (large1) antibody
  • glycosyltransferase-like protein LARGE1 (LOC100118066) antibody
  • like-glycosyltransferase (LARGE) antibody
  • like-glycosyltransferase (Large) antibody
  • BPFD36 antibody
  • DKFZp459G0120 antibody
  • enr antibody
  • fg antibody
  • froggy antibody
  • Gyltl1a antibody
  • gyltl1b antibody
  • gyltl1b-b antibody
  • Mbp-1 antibody
  • Mbp1 antibody
  • MDC1D antibody
  • MDDGA6 antibody
  • MDDGB6 antibody
  • mKIAA0609 antibody
  • myd antibody
  • NV15834 antibody

Protein level used designations for LARGE

glycosyltransferase-like 1B , glycosyltransferase-like 1B-B , glycosyltransferase-like protein LARGE2-B , acetylglucosaminyltransferase-like 1A , acetylglucosaminyltransferase-like protein , glycosyltransferase-like protein LARGE1 , like-acetylglucosaminyltransferase , myodystrophy , glycosyltransferase-like 1A , like-glycosyltransferase , glycosyltransferase-like protein LARGE1-like , eosinophil granule major basic protein 1 , prepro major basic protein 1

GENE ID SPECIES
734944 Xenopus laevis
9215 Homo sapiens
16795 Mus musculus
361368 Rattus norvegicus
418062 Gallus gallus
446213 Danio rerio
470192 Pan troglodytes
474521 Canis lupus familiaris
506466 Bos taurus
717403 Macaca mulatta
100068935 Equus caballus
100118066 Nasonia vitripennis
100174135 Pongo abelii
100346008 Oryctolagus cuniculus
100366528 Saccoglossus kowalevskii
100410756 Callithrix jacchus
100466251 Ailuropoda melanoleuca
100286788 Cavia porcellus
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