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LARGE Products

(Like-Glycosyltransferase (LARGE))
This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008].

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Featured LARGE Categories

LARGE Antibodies

High quality antibodies with extensive validation data.

LARGE ELISA Kits

Reliable ELISA kits for a wide range of species.

LARGE Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended LARGE Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN571148
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN635429
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB
Validations
  • (1)
Cat. No. ABIN2782650
Quantity 100 μL
Datasheet Datasheet

Recommended LARGE ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1135280
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1135279
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method
Validations
Cat. No. ABIN1135278
Quantity 96 tests
Datasheet Datasheet

Recommended LARGE Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3137602
Quantity 0.25 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093481
Quantity 0.5 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093482
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our LARGE products

Saito, Kanagawa, Ikeda, Hagiwara, Masaki, Ohkuma, Katanosaka, Shimizu, Sonoo, Toda, Matsumura: "Overexpression of LARGE suppresses muscle regeneration via down-regulation of insulin-like growth factor 1 and aggravates muscular dystrophy in mice." in: Human molecular genetics, Vol. 23, Issue 17, pp. 4543-58, (2014) (PubMed).

Reissner, Stahn, Breuer, Klose, Pohlentz, Mormann, Missler: "Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain." in: The Journal of biological chemistry, Vol. 289, Issue 40, pp. 27585-603, (2014) (PubMed).

de Bernabé, Inamori, Yoshida-Moriguchi, Weydert, Harper, Willer, Henry, Campbell: "Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11279-84, (2009) (PubMed).

Synonyms and alternative names related to LARGE

LARGE xylosyl- and glucuronyltransferase 1 L homeolog (large1.L), LARGE xylosyl- and glucuronyltransferase 1 (LARGE1), LARGE xylosyl- and glucuronyltransferase 1 (Large1), LARGE xylosyl- and glucuronyltransferase 1 (large1), glycosyltransferase-like protein LARGE1 (LOC100118066), like-glycosyltransferase (LARGE), like-glycosyltransferase (Large), BPFD36, DKFZp459G0120, enr, fg, froggy, Gyltl1a, gyltl1b, gyltl1b-b, Mbp-1, Mbp1, mdc1d, MDC1D, MDDGA6, MDDGB6, mKIAA0609, myd, NV15834

Protein level used designations for LARGE

  • glycosyltransferase-like 1B
  • glycosyltransferase-like 1B-B
  • glycosyltransferase-like protein LARGE2-B
  • acetylglucosaminyltransferase-like 1A
  • acetylglucosaminyltransferase-like protein
  • glycosyltransferase-like protein LARGE1
  • like-acetylglucosaminyltransferase
  • myodystrophy
  • glycosyltransferase-like 1A
  • like-glycosyltransferase
  • glycosyltransferase-like protein LARGE1-like
  • eosinophil granule major basic protein 1
  • prepro major basic protein 1
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