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The data of the present study demonstrated that the PCSK9 shRNAmediated antiapoptotic effect induced by MCAO in hyperlipidemic mice is associated with ApoER2 downregulation, which may be a potential new therapy for stroke treatment in patients with hyperlipidemia.
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Stage-specific labeling of newborn Apoer2-deficient neurons revealed that the neurons ectopically invaded the marginal zone and that neuronal migration of both early- and late-born neurons was disrupted in the intermediate zone in the Apoer2 KO mice. Rescue experiments showed that ApoER2 functions both in cell-autonomous and noncell-autonomous manners.
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GRIP1 binds to apoER2 and EphrinB2 to induce activity-dependent AMPA receptor insertion at the synapse.
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A1-A1, which is a soluble analog of ApoER2 that binds pathological beta2GPI/anti-beta2GPI complexes, has a positive impact on hemodynamics in lupus-prone mice with spontaneous anti-beta2GPI antibodies and hypertension
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findings indicate that impaired processing or localization of apoER2 may contribute to the pathogenic effects of familial Alzheimer's disease mutations in PS1
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reveals a novel function for Reelin/ApoER2 in peripheral nervous system, inducing cell migration of Schwann cells, a process relevant for peripheral nervous system development and regeneration
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total levels of ApoER2 and surface levels of ApoER2 are increased by active Fyn
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This study demonstrated that ApoER2 is expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex.
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This study demonistrated that LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation in mice.
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Apoer2 lacking exon 16, the O-linked sugar domain, altered the proteolytic processing and abundance of Apoer2 in cells and synapse number and function in mice, hippocampal spine density, LTP, and cued fear learning.
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genetic variants of apoE and ApoER2 impact cardiovascular health by differentially modulating endothelial function.
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Study shows that the levels of hippocampal ApoE receptors Lrp1 and Apoer2 in vivo are affected isoform specifically by ApoE4 and that the type of receptor affected is context dependent
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Tandem Sepp1-apoER2 interactions supply selenium for maintenance of brain neurons both at the blood-brain barrier and within the brain. Sepp1 inside the blood-brain barrier is taken up by neurons via apoER2, concentrating brain selenium in them.
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data demonstrate that several multivalent ligands for ApoER2 induce clustering in transfected cells and primary neurons and that these complexes included other synaptic molecules, such as APP and PSD-95
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Apolipoprotein E receptor-2 deficiency enhances macrophage susceptibility to lipid accumulation and cell death to augment atherosclerotic plaque progression and necrosis.
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longer isoforms of Sepp1 with high selenium content interact with a binding site distinct from the ligand-binding domain of apoER2 for selenium delivery
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Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway.
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The Reelin receptors ApoER2 and VLDLr play essential roles in Reelin-mediated migration and positioning of mesencephalic dopaminergic neurons.
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Dab1 mediated the association of CIN85 with ApoER2 or VLDLR in neurons.
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there are reelin-independent functions of very-low-density lipoprotein receptor (VLDLR) and low-density lipoprotein receptor-related protein 8 in geniculate nucleus development.
