anti-Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8) Antibodies

Human Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8) interaction partners

1. Data indicate low-density lipoprotein receptor-related protein 8 (LRP8) as a therapeutic target for triple-negative breast cancer (TNBC) as inhibition of LRP8 can attenuate Wnt/beta-catenin signaling to suppress breast cancer stem cells (BCSCs).

2. CSF-ApoER2 fragments as a read-out of reelin signaling: Distinct patterns in sporadic and autosomal-dominant Alzheimer disease

3. ApoER2-CTF levels are decreased in AD brain at advanced Braak stages and after Abeta treatment.

4. ABGL4, LRP8 and PCSK9 polymorphisms and gene interactions increase cardiometabolic risk.

5. This study elucidates that the contracted-open conformation of ligand-bound ApoER2 at neutral pH resembles the contracted-closed conformation of ligand-unbound low-density lipoprotein receptor at acidic pH in a manner suggestive of being primed for ligand release even prior to internalization.

6. LRP8 is a risk gene for psychosis.

7. Results show that none of the SNPs were significantly associated with myocardial infarction (MI). Interestingly, haplotype based association analysis showed TG and CG of rs10788952 and rs7546246 significantly associated with MI and in particular, haplotype TG was positively correlated with the risk of MI, as this increased the LDL and total cholesterol level in MI patients in south Indians.

8. These results reveal an association between ApoER2 isoform expression and Alzheimer's disease.

9. The presence of reelin was elevated in junctional areas as in dysplastic nevi. VLDLR presented positive values in 16 cases (16/ 32) and ApoER2 was weak positive in 7 cases.

10. ApoER2 contributes cooperatively with endothelial cell protein C receptor and protease activated receptor 1 to APC-initiated endothelial antiapoptotic and barrier protective signaling.

11. two SNPs (rs3737984 and rs2297660) in ApoER2 gene had significant association with dyslipidemia in Thai ethnic

12. A novel TACGC risk haplotype in the LRP8 gene that is present in patients with CAD and MI but not in normal controls.

13. results of this study demonstrated the presence of reelin, its receptors VLDLR and ApoER2 as well as Dab1 in the ENS and might indicate a novel role of the reelin system in regulating neuronal plasticity and pre-synaptic functions in the ENS.

14. Data suggest that PS1/gamma-secretase-dependent processing of the reelin receptor ApoER2 inhibits reelin expression and may regulate its signaling.

15. ectopic expression of HIC1 in U2OS and MDA-MB-231 cell lines decreases expression of the ApoER2 and VLDLR genes, encoding two canonical tyrosine kinase receptors for Reelin.

16. By incorporating the information from bioinformatics and RNA expression analyses, we identified at least two of the most promising risk genes for alcohol dependence: APOER2 and UBAP2

17. TCCGC haplotype at the 3'-terminal block of the LRP8 gene confers a protective role in the development of familial and early-onset coronary artery disease and/or myocardial infarction.

18. In a Chinese unrelated Han population, variants within the LRP8 gene do not convey the risk of developing Parkinson's disease.

19. results identify LRP8 as a novel positive factor of canonical Wnt signaling pathway

20. Variation in genes encoding proteins at the gateway of Reelin signaling: ligands RELN and APOE, their common receptors APOER2 and VLDLR, and adaptor DAB1, was examined.

Mouse (Murine) Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8) interaction partners

1. The data of the present study demonstrated that the PCSK9 shRNAmediated antiapoptotic effect induced by MCAO in hyperlipidemic mice is associated with ApoER2 downregulation, which may be a potential new therapy for stroke treatment in patients with hyperlipidemia.

2. Stage-specific labeling of newborn Apoer2-deficient neurons revealed that the neurons ectopically invaded the marginal zone and that neuronal migration of both early- and late-born neurons was disrupted in the intermediate zone in the Apoer2 KO mice. Rescue experiments showed that ApoER2 functions both in cell-autonomous and noncell-autonomous manners.

3. GRIP1 binds to apoER2 and EphrinB2 to induce activity-dependent AMPA receptor insertion at the synapse.

4. A1-A1, which is a soluble analog of ApoER2 that binds pathological beta2GPI/anti-beta2GPI complexes, has a positive impact on hemodynamics in lupus-prone mice with spontaneous anti-beta2GPI antibodies and hypertension

5. findings indicate that impaired processing or localization of apoER2 may contribute to the pathogenic effects of familial Alzheimer's disease mutations in PS1

6. reveals a novel function for Reelin/ApoER2 in peripheral nervous system, inducing cell migration of Schwann cells, a process relevant for peripheral nervous system development and regeneration

7. total levels of ApoER2 and surface levels of ApoER2 are increased by active Fyn

8. This study demonstrated that ApoER2 is expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex.

9. This study demonistrated that LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation in mice.

10. Apoer2 lacking exon 16, the O-linked sugar domain, altered the proteolytic processing and abundance of Apoer2 in cells and synapse number and function in mice, hippocampal spine density, LTP, and cued fear learning.

11. genetic variants of apoE and ApoER2 impact cardiovascular health by differentially modulating endothelial function.

12. Study shows that the levels of hippocampal ApoE receptors Lrp1 and Apoer2 in vivo are affected isoform specifically by ApoE4 and that the type of receptor affected is context dependent

13. Tandem Sepp1-apoER2 interactions supply selenium for maintenance of brain neurons both at the blood-brain barrier and within the brain. Sepp1 inside the blood-brain barrier is taken up by neurons via apoER2, concentrating brain selenium in them.

14. data demonstrate that several multivalent ligands for ApoER2 induce clustering in transfected cells and primary neurons and that these complexes included other synaptic molecules, such as APP and PSD-95

15. Apolipoprotein E receptor-2 deficiency enhances macrophage susceptibility to lipid accumulation and cell death to augment atherosclerotic plaque progression and necrosis.

16. longer isoforms of Sepp1 with high selenium content interact with a binding site distinct from the ligand-binding domain of apoER2 for selenium delivery

17. Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway.

18. The Reelin receptors ApoER2 and VLDLr play essential roles in Reelin-mediated migration and positioning of mesencephalic dopaminergic neurons.

19. Dab1 mediated the association of CIN85 with ApoER2 or VLDLR in neurons.

20. there are reelin-independent functions of very-low-density lipoprotein receptor (VLDLR) and low-density lipoprotein receptor-related protein 8 in geniculate nucleus development.

Cow (Bovine) Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8) interaction partners

1. genetic variants of apoE and ApoER2 impact cardiovascular health by differentially modulating endothelial function.[ApoER2]

2. the differential expression patterns of LRP8 mRNA during final follicular growth and ovulation