Lymphocyte Cytosolic Protein 1 Proteins (LCP1)

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. Additionally we are shipping LCP1 Antibodies (138) and LCP1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LCP1 3936 P13796
Rat LCP1 LCP1 306071  
LCP1 18826 Q61233
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Top LCP1 Proteins at

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Escherichia coli (E. coli) REACT_Cytomegalovirus His tag   100 μg 2 to 3 Days
Escherichia coli (E. coli) Human His tag 100 μg 15 to 18 Days

LCP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Top referenced LCP1 Proteins

  1. Human LCP1 Protein expressed in HEK-293 Cells - ABIN2729119 : Dubey, Singh, Awasthi, Nagarkoti, Kumar, Ali, Chandra, Kumar, Barthwal, Jagavelu, Sánchez-Gómez, Lamas, Dikshit: L-Plastin S-glutathionylation promotes reduced binding to β-actin and affects neutrophil functions. in Free radical biology & medicine 2015 (PubMed)

More Proteins for Lymphocyte Cytosolic Protein 1 (LCP1) Interaction Partners

Human Lymphocyte Cytosolic Protein 1 (LCP1) interaction partners

  1. LCP1-positive oral squamous cell carcnome samples were correlated closely with the primary tumor size and regional lymph node metastasis.

  2. MOLP8/R cells display a very high overexpression of LCP1 gene (l-Plastin) controlled by HIF1&alpha.

  3. these findings support a plausible mechanism by which the AP4/L-plastin axis is regulated by the PI3K/AKT pathway in human prostate cancer (PCa)and may represent a novel therapeutic target in PCa treatment.

  4. Mutated LCP1 is a driver of chronic lymphocytic leukemia.

  5. AngII-dependent phosphorylation of LCP1 in cultured podocytes was mediated by the kinases ERK, p90 ribosomal S6 kinase, PKA, or PKC. LCP1 phosphorylation increased filopodia formation.

  6. L-plastin regulates the stability of the immune synapse of naive and effector T-cells. (Review)

  7. The findings support a mechanism in which miR-375 suppresses RUNX1 levels, resulting in reduced vimentin and L-plastin expression. Knockdown of RUNX1, L-plastin, and vimentin resulted in significant reductions in cell invasion in vitro, indicating the functional significance of miR-375 regulation of specific proteins involved in head and neck squamous cell carcinoma (HNSCC) invasion.

  8. In this study, the authors found that the actin filament bundling abilities of PLS1 and PLS2 were similarly sensitive to Ca(2+) (pCa50 ~6.4), whereas PLS3 was less sensitive (pCa50 ~5.9).

  9. elevated L-plastin expression promotes elongation and reduces protrusion density in cells with relatively lower L-plastin than fascin levels.

  10. Enhanced nitroxidative stress may results in LPL S-glutathionylation leading to impaired chemotaxis, polarization, and bactericidal activity of human neutrophils.

  11. association of SNPs in LCP1 and CTIF with hearing

  12. An NKX3.1 binding site polymorphism in the l-plastin promoter leads to differential gene expression in human prostate cancer

  13. The proteins (HSP90b, TSM1 and L-plastin) in the current study may hold potential in differentiating between melanoma and benign nevi in diagnostically challenging cases.

  14. Data suggest that several single-nucleotide polymorphisms (SNPs) of the plastin genes PLS3 and LCP1 could serve as gender- and/or stage-specific molecular predictors of tumor recurrence in stage II/III colorectal cancer as well as therapeutic targets.

  15. L-plastin plays an important role in the clustering of NKG2D into lipid rafts, and it participates in NKG2D-mediated inhibition of NK cell chemotaxis.

  16. expression of L-plastin promotes tumor metastasis and, importantly, that this effect depends on an additionally required phosphorylation of L-plastin

  17. L-plastin is indispensable for podosome formation and function in macrophages.

  18. LCP1 is functionally relevant to CXCL12 induced B-cell migration.

  19. High serum LCP1 is associated with kidney cancer.

  20. Hepatic LCP1 mRNA was increased (by 300%) in liver biopsy samples from patients with nonalcoholic fatty liver disease compared to controls

Mouse (Murine) Lymphocyte Cytosolic Protein 1 (LCP1) interaction partners

  1. It is shown that TNF-alpha signaling regulates the phosphorylation of serine-5 and -7 in L-plastin which increases the actin bundling capacity of L-plastin and hence the formation of nascent sealing zones in mouse osteoclasts.

  2. the actin-bundling protein L-plastin (LPL) is required for the perinatal development of alveolar macrophages.

  3. Results identify L-plastin as a key effector of Mst1 and establish a novel mechanism linking a signaling intermediate to an actin-binding protein critical to T cell migration.

  4. L-plastin modulates both T- and B-cell function during the germinal center reaction and the production of T-cell-dependent antibody responses.

  5. L-plastin may participate in signaling that enables lymphocyte transmigration

  6. LPL-dependent actin bundling facilitates the formation of lamellipodia and normal immunological synapses and thereby enables T cell activation.

  7. Regulation of sealing ring formation by L-plastin and cortactin in osteoclasts.

  8. We thus identify L-plastin as a molecule critical for CCR7-mediated t-cell motility but dispensable for early CCR7 signaling.

  9. plastin plays a role in host defense distinguishes integrin signaling from cell adhesion and spreading.

LCP1 Protein Profile

Protein Summary

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.

Gene names and symbols associated with LCP1

  • lymphocyte cytosolic protein 1 (LCP1)
  • lymphocyte cytosolic protein 1 (L-plastin) (lcp1)
  • lymphocyte cytosolic protein 1 (L-plastin) S homeolog (lcp1.S)
  • lymphocyte cytosolic protein 1 (Lcp1)
  • lower matrix protein; involved in immune regulation (UL83)
  • AW536232 protein
  • cb245 protein
  • cp64 protein
  • D14Ertd310e protein
  • fj24b12 protein
  • l-plastin protein
  • lc64p protein
  • LCP-1 protein
  • lpl protein
  • plastin-2 protein
  • Pls2 protein
  • pp65 protein
  • wu:fj24b12 protein

Protein level used designations for LCP1

L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P) , LCP-1 , Lymphocyte cytosolic protein-1 (plasmin) , bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)) , plastin 2 , plastin-2 , L-plastin , leucocyte-specific plastin 1 , 65 kDa macrophage protein , L-fimbrin , L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65) , plastin 2, L , 65 kDa matrix phosphoprotein , Phosphoprotein UL83 , Tegument protein UL83 , involved in immune regulation , lower matrix protein , tegument protein pp65

3936 Homo sapiens
30583 Danio rerio
379911 Xenopus laevis
306071 Rattus norvegicus
418852 Gallus gallus
476921 Canis lupus familiaris
540990 Bos taurus
18826 Mus musculus
3077579 Human betaherpesvirus 5
100156254 Sus scrofa
100717499 Cavia porcellus
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