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MARK4 encodes a member of the microtubule affinity-regulating kinase family.
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Human Polyclonal MARK4 Primary Antibody for ELISA, WB - ABIN249489
Kato, Satoh, Okabe, Kitahara, Ono, Kihara, Tanaka, Tsunoda, Yamaoka, Nakamura, Furukawa: Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis. in Neoplasia (New York, N.Y.) 2001
data demonstrate that miR (show MLXIP Antibodies)-515-5p dramatically inhibits cell migration by directly down-regulating MARK4 expression in two different cancer types
Our results show that MARK4 acts as a negative regulator of the Hippo kinase cassette to promote YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) activity and that loss of MARK4 restrains the tumorigenic properties of breast cancer cells.
Atypical PKC (show PRRT2 Antibodies) phosphorylates serine-threonine residues of MARK4.
Suggest role for polypyrimidine-tract binding protein (show PTBP1 Antibodies) in regulating alternative splicing of MARK4 in gliomas.
MARK4 is a key component in the regulation of microtubule dynamics and has major role in cell cycle progression, particularly at the G1/S transition.
Molecular dynamic simulation data predicted the three dimensional structure for the kinase domain of MARK4 and its structural properties.
A strong and significant elevation of MARK4 expression and MARK4-tau interactions in AD brains correlates with the Braak stages of the disease, suggesting that the MARK4-tau interactions are of functional importance in the progression of AD.
MARK4 is a critical positive regulator of early steps in ciliogenesis.
MARK4 is a new negative regulator of mTORC1
The balance between the MARK4 isoforms is carefully guarded during neural differentiation but may be subverted in gliomagenesis.
PPARgamma (show PPARG Antibodies) interacted with Mark4 and inhibited the stimulating effect of Mark4 on oxidative stress and inflammation.
data indicate a key role of MARK4 in energy metabolism, implicating the kinase as a novel drug target for the treatment of obesity and type 2 diabetes.
MARK4 is a functional protein kinase (show CDK7 Antibodies) which specifically phosphorylates a cognate peptide substrate for the AMP (show TMPRSS5 Antibodies)-kinase family. On overexpression in heterologous cells functional wild-type protein, but not its kinase-dead mutant, decreased cell viability
This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
MAP/microtubule affinity-regulating kinase 4
, MAP/microtubule affinity-regulating kinase like 1
, MARK4 serine/threonine protein kinase
, MAP/microtubule affinity-regulating kinase 4L