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The oncogenic protein encoded by MCF2 is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases.
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Results support a role for Dbl oncogene (show RAB1A Proteins) in mammary epithelial cell differentiation and transformation and suggest the relevance of GEF (show SLC2A4RG Proteins) deregulation in tumor onset and progression.
Phosphoinositide 3-kinase C2beta regulates RhoA (show RHOA Proteins) and the actin cytoskeleton through an interaction with Dbl
Dbl is regulated by hamartin (show TSC1 Proteins) through association with ezrin (show EZR Proteins).
proto-oncogene dbl is not a major target for sporadic testicular germ cell tumors
data describe 4 splicing variants of the human DBL (MCF-2) proto-oncogene (show RAB1A Proteins) that show different tissue distributions and guanine nucleotide exchange factor (show RASGRF1 Proteins) specificities
provides fundamental data on the structure of Mcf-2, which regulates a variety of cellular signaling pathways
These data suggest a mechanism whereby precise spatial guanine nucleotide exchange of Cdc42 (show CDC42 Proteins) by Dbl is dependent on functional ERM (show ETV5 Proteins) proteins and is important for directional cell migration.
Galphaq (show GNAQ Proteins) directly activates p63RhoGEF and Trio (show TRIO Proteins) via a conserved extension of the Dbl homology-associated pleckstrin (show PLEK Proteins) homology domain
Nm23-H1 (show NME1 Proteins) can negatively regulate cell migration and tumor metastasis by modulating the activity of Cdc42 (show CDC42 Proteins) and possibly other Rho family members through interaction with Dbl-1
The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.
Oncogene MCF2 (oncogene DBL)
, proto-oncogene DBL
, proto-oncogene MCF-2