anti-Major Vault Protein (MVP) Antibodies

MVP encodes the major component of the vault complex. Additionally we are shipping Major Vault Protein Kits (41) and Major Vault Protein Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MVP 9961 Q14764
MVP 64681 Q62667
MVP 78388  
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Top anti-Major Vault Protein Antibodies at antibodies-online.com

Showing 9 out of 239 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-MVP Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: COLO205 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), SimWes, WB Immunocytochemistry/Immunofluorescence: MVP Antibody [NBP1-82820] - Staining of human cell line U-251 MG shows positivity in cytoplasm. Simple Western: MVP Antibody [NBP1-82820] - Electropherogram image(s) of corresponding Simple Western lane view. MVP antibody was used at 1:30 dilution on RT-4 and U-251MG lysate(s). 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Immunohistochemistry-Paraffin: MVP Antibody [NBP1-33560] - Paraffin-embedded A549 xenograft, using antibody at 1:500 dilution. Immunocytochemistry/Immunofluorescence: MVP Antibody [NBP1-33560] - Paraformaldehyde-fixed A431, using antibody at 1:200 dilution. 100 μL Log in to see 8 to 11 Days
$516.98
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: MVP Antibody [NBP1-31295] - Sample (30 ug of whole cell lysate) A:NIH-3T37C 5% SDS PAGE; antibody diluted at 1:1000. Western Blot: MVP Antibody [NBP1-31295] - Sample (30 ug of whole cell lysate) A: Hela 7. 5% SDS PAGE LRP(MVP) antibody, antibody diluted at 1:1000. 100 μL Log in to see 8 to 11 Days
$516.98
Details
Human Rabbit Un-conjugated ELISA, FACS, ICC, IHC, WB Western blot analysis of MVP using anti-MVP antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: human placenta tissue lysates, Lane 2: human HepG2 whole cell lysates,  Lane 3: human A549 whole cell lysates,  Lane 4: human PANC-1 whole cell lysates,  Lane 5: human SGC-7901 whole cell lysates,  Lane 6: human MDA-MB-231 whole cell lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-MVP antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for MVP at approximately 99KD. The expected band size for MVP is at 99KD. Western blot analysis of MVP using anti-MVP antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat spleen tissue lysates, Lane 2: rat lung tissue lysates, Lane 3: rat kidney tissue lysates, Lane 4: mouse spleen tissue lysates, Lane 5: mouse lung tissue lysates, Lane 6: mouse kidney tissue lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-MVP antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for MVP at approximately 99KD. The expected band size for MVP is at 99KD. 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Human A549 Cells; Lane2: Human Hela Cells; Lane3: Human Lung Tissue. 100 μg Log in to see 13 to 16 Days
$332.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of Hela whole cell lysates, using MVP Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276995 at 1/100 staining Rat brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: Hela 7.5% SDS PAGE LRP(MVP) antibody antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded human gastric , using MVP/LRP, antibody at 1:100 dilution. 100 μL Log in to see 3 to 4 Days
$466.18
Details

Top referenced anti-Major Vault Protein Antibodies

  1. Fish Polyclonal MVP Primary Antibody for IF (p), IHC (p) - ABIN671586 : Hu, Peng, Li: The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer. in Journal of experimental & clinical cancer research : CR 2009 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal MVP Primary Antibody for ELISA, WB - ABIN545724 : Aronica, Gorter, van Vliet, Spliet, van Veelen, van Rijen, Leenstra, Ramkema, Scheffer, Scheper, Sisodiya, Troost: Overexpression of the human major vault protein in gangliogliomas. in Epilepsia 2003 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal MVP Primary Antibody for IF, IHC (p) - ABIN564285 : Rahimi, Wilson, Saylor, Stelow, Thomas, Reibel, Levine, Shonka, Jameson, Read: p16, Cyclin D1, and HIF-1? Predict Outcomes of Patients with Oropharyngeal Squamous Cell Carcinoma Treated with Definitive Intensity-Modulated Radiation Therapy. in International journal of otolaryngology 2012 (PubMed)

  4. Human Polyclonal MVP Primary Antibody for ELISA, IHC - ABIN6263445 : Zhou, Lin, Zhang, Zhang, Zhang, Zhang, Xie, Ren: miR-506 enhances the sensitivity of human colorectal cancer cells to oxaliplatin by suppressing MDR1/P-gp expression. in Cell proliferation 2017 (PubMed)

More Antibodies against Major Vault Protein Interaction Partners

Human Major Vault Protein (MVP) interaction partners

  1. B7-H3 is associated with the major vault protein (MVP) and activates MEK through MVP-enhancing B-RAF and MEK interaction. B7-H3 expression increases stem cell population by binding to MVP which regulates the activation of the MAPK kinase pathway. Depletion of MVP blocks the activation of MEK induced by B7-H3 and dramatically inhibits B7-H3 induced stem cells.

  2. KPNA7 binding and nuclear transfer was validated for two proteins, MVP and ZNF414. MVP and ZNF414 have a key role in the regulation of pancreatic cancer cell growth.

  3. Knockout of MVP leads to miR-193a accumulation in the exosomal donor cells instead of exosomes, inhibiting tumour progression.

  4. The expression levels of LRP and GSTP1 in primary epithelial ovarian cancer were the highest, followed by borderline adenoma tissues, and lowest levels in benign tumor tissues. The difference between resistant gene negative-expression and positive-expression of chemotherapy efficiency, disease free survival time, and recurrence time were statistically significant.

  5. KIF4A promotes drug resistance of lung adenocarcinoma cells through transporting LRP-based vaults along microtubules towards the cell membrane

  6. Major vault protein is important in the drug resistance of cancer cells, but it requires the presence of vPARP for full activity

  7. involved in doxorubicin resistance of non-small cell lung cancer

  8. Study found significant upregulation of MVP and BCRP whereas MRP1 and UGT1A4 were unaltered in drug resistant epilepsy brains. While upregulation of BCRP was significantly higher in mesial temporal lobe epilepsy (9.34+/-0.45; p<0.05), upregulation of MVP was significantly higher in focal cortical dysplasia (2.94+/-0.65; p<0.01).

  9. Taxus chinensis var.-mediated downregulation of MRP1, MDR1, and LRP might contribute to the reversal of drug resistance in non-small cell lung cancer stem cells.

  10. We believe that for the first time, genetic variants at XRCC6 and MVP genes are associated with risk of more aggressive disease, and would be taken into account when assessing the malignancy of prostate cancer

  11. MVP genetic polymorphisms and haplotypes may not be associated with drug resistance of partial epilepsy in the Chinese Han population.

  12. NSCLCs [ non-small cell lung cancer ] expressing P-gp [P-glycoprotein ]/LRP [ lung resistance-related protein] bear the EGFR [epidermal growth factor receptor] mutation in exon 19 or 21 easily.

  13. The association of MVP amplification and PTEN deletion could be a potential biomarker in glioblastoma.

  14. Bag3-MVP is an important complex that regulates a potent prosurvival signaling pathway and contributes to chemotherapy resistance in breast cancer

  15. LDL increases ABCB1, ABCC1, and LRP expression in a human doxorubicin-resistant uterine sarcoma cell line.

  16. Study demonstrates that vaults have a tumour-promoting potential by stabilizing EGFR/PI3K-mediated migration and survival pathways in human glioblastoma.

  17. USF1 binding to an E-box element may be critical for basal MVP promoter activation.

  18. hyperosmotic stress upregulates Sp1 expression levels by inhibiting ubiquitination through the activation of JNK, and the induction of Sp1 expression directly enhances MVP transcription.

  19. the protein levels of MVP, TEP1 and vPARP are actually increased in the highergrade tumors suggesting existence of post-transcriptional regulation of vault component production.

  20. Lung resistance-related protein is associated with malignant ascitic cells and recurrence in ovarian serous carcinoma.

Mouse (Murine) Major Vault Protein (MVP) interaction partners

  1. plays major role in anti-viral immunity

  2. MVP may fine-tune SR-A activity in macrophages which contributes to the development of atherosclerosis

  3. MVP is hijacked by L. monocytogenes in order to counteract the autophagy process, a finding that could have major implications in deciphering the cellular role of vault particles.

  4. These results suggest that up-regulation of MVP in multi-drug resistance (MDR) may involve chromatin remodeling.

  5. Results suggest that major vault protein functions as a novel scaffold protein for both SHP-2 and Erk.

  6. results suggest that MVP makes a substantial contribution to epithelial cell-mediated resistance to infection

  7. The crystal structure of the vault particle solved at 8 A resolution, together with the 2.1-A structure of the seven N-terminal domains (R1-R7) of MVP, provide an explanation for a reversible dissociation induced by low pH.

Zebrafish Major Vault Protein (MVP) interaction partners

  1. MVP is beneficial for functional recovery and axonal regrowth after spinal cord injury in adult zebrafish.

Purple Sea Urchin (Strongylocentrotus purpuratus) Major Vault Protein (MVP) interaction partners

  1. structure and cellular localization during embryonic development; findings indicate a dramatic relocalization of MVP from the cytoplasm to the nucleus during sea urchin embryogenesis

Major Vault Protein (MVP) Antigen Profile

Protein Summary

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.

Gene names and symbols associated with MVP

  • major vault protein (MVP) antibody
  • major vault protein (Mvp) antibody
  • major vault protein (mvp) antibody
  • major vault protein L homeolog (mvp.L) antibody
  • major vault protein (Tc00.1047053510353.10) antibody
  • major vault protein (Tb927.5.4460) antibody
  • major vault protein (Tb10.70.0520) antibody
  • major vault protein (Tb10.70.5840) antibody
  • putative major vault protein (LMJF_05_0060) antibody
  • 2310009M24Rik antibody
  • cb771 antibody
  • LRP antibody
  • MGC145641 antibody
  • mvp antibody
  • Tb05.45E22.810 antibody
  • VAULT1 antibody
  • wu:fb52b05 antibody
  • wu:fc02g01 antibody

Protein level used designations for MVP

lung resistance-related protein , major vault protein , lung resistance-associated protein

GENE ID SPECIES
9961 Homo sapiens
64681 Rattus norvegicus
78388 Mus musculus
373081 Danio rerio
379630 Xenopus laevis
420049 Gallus gallus
516456 Bos taurus
575735 Strongylocentrotus purpuratus
779746 Xenopus (Silurana) tropicalis
3535684 Trypanosoma cruzi strain CL Brener
3657553 Trypanosoma brucei brucei strain 927/4 GUTat10.1
3662971 Trypanosoma brucei brucei strain 927/4 GUTat10.1
3663013 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5648865 Leishmania major strain Friedlin
100380384 Salmo salar
100622738 Sus scrofa
100726794 Cavia porcellus
100340748 Oryctolagus cuniculus
479783 Canis lupus familiaris
101119435 Ovis aries
100172829 Pongo abelii
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