Major Vault Protein (MVP) (C-Term) antibody

Details for Product No. ABIN2854785
Target
Binding Specificity
C-Term
11
10
7
5
3
3
2
2
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse
142
31
31
2
2
2
2
2
2
1
1
1
1
1
1
1
Host
Rabbit
73
68
5
Clonality
Polyclonal
Conjugate
Un-conjugated
9
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
81
70
53
50
37
36
16
16
10
8
4
3
3
3
2
2
1
1
Options
Immunogen Recombinant protein encompassing a sequence within the C-terminus region of human MVP/LRP. The exact sequence is proprietary.
Isotype IgG
Cross-Reactivity Rat (Rattus), Cow (Bovine)
Cross-Reactivity (Details) Rat (91 %), Bovine (93 %)
Characteristics Rabbit Polyclonal antibody to MVP/LRP (major vault protein)
MVP/LRP antibody [C2C3], C-term
Purification Purified by antigen-affinity chromatography.
Target
Alternative Name MVP/LRP (MVP Antibody Abstract)
Background This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences, however, the open reading frames are the same in both transcripts.

Cellular Localization: Cytoplasm , Nucleus , nuclear pore complex
Molecular Weight 99 kDa
Gene ID 9961
Application Notes Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
Comment

Positive Control: A431 , H1299 , HeLa , HepG2 , NIH-3T3

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1XPBS, 1 % BSA, 20 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Images
Image no. 1 for anti-Major Vault Protein (MVP) (C-Term) antibody (ABIN2854785) WB Image Sample (30 ug of whole cell lysate) A: Hela 7.5% SDS PAGE LRP(MVP) antibody ...
Image no. 2 for anti-Major Vault Protein (MVP) (C-Term) antibody (ABIN2854785) IHC-P Image Immunohistochemical analysis of paraffin-embedded human gastric , using M...
Image no. 3 for anti-Major Vault Protein (MVP) (C-Term) antibody (ABIN2854785) WB Image Sample (30 ug of whole cell lysate) A:NIH-3T3 7.5% SDS PAGE antibody diluted...