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MVP Products

(Major Vault Protein (MVP))
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].

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Featured MVP Categories

MVP Antibodies

High quality antibodies with extensive validation data.

MVP ELISA Kits

Reliable ELISA kits for a wide range of species.

MVP Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MVP Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, FACS, ICC, IHC, WB
Validations
  • (6)
Cat. No. ABIN5692897
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, FACS, IHC (p), WB
Validations
  • (7)
Cat. No. ABIN5708257
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application ICC, IF, IHC (p), WB
Validations
  • (5)
Cat. No. ABIN2856921
Quantity 100 μL
Datasheet Datasheet

Recommended MVP ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957625
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative
Validations
Cat. No. ABIN773458
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN770995
Quantity 96 tests
Datasheet Datasheet

Recommended MVP Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1311678
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3137190
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3094021
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our MVP products

Bornachea, Benitez-Amaro, Vea, Nasarre, de Gonzalo-Calvo, Escola-Gil, Cedo, Iborra, Martínez-Martínez, Juarez, Camara, Espinet, Borrell-Pages, Badimon, Castell, Llorente-Cortés: "Immunization with the Gly1127-Cys1140 amino acid sequence of the LRP1 receptor reduces atherosclerosis in rabbits. Molecular, immunohistochemical and nuclear imaging studies." in: Theranostics, Vol. 10, Issue 7, pp. 3263-3280, (2020) (PubMed).

Zhou, Lin, Zhang, Zhang, Zhang, Zhang, Xie, Ren: "miR-506 enhances the sensitivity of human colorectal cancer cells to oxaliplatin by suppressing MDR1/P-gp expression." in: Cell proliferation, Vol. 50, Issue 3, (2017) (PubMed).

de Gonzalo-Calvo, López-Vilaró, Nasarre, Perez-Olabarria, Vázquez, Escuin, Badimon, Barnadas, Lerma, Llorente-Cortés: "Intratumor cholesteryl ester accumulation is associated with human breast cancer proliferation and aggressive potential: a molecular and clinicopathological study." in: BMC cancer, Vol. 15, pp. 460, (2016) (PubMed).

Zhang, Neo, Gunaratne, Poulsen, Boping, Ong, Sangthongpitag, Pendharkar, Hill, Cohen: "Feedback regulation on PTEN/AKT pathway by the ER stress kinase PERK mediated by interaction with the Vault complex." in: Cellular signalling, Vol. 27, Issue 3, pp. 436-42, (2015) (PubMed).

Peng, Feng, Yuan, Benhabbour, Mumper: "Development of a novel orthotopic non-small cell lung cancer model and therapeutic benefit of 2'-(2-bromohexadecanoyl)-docetaxel conjugate nanoparticles." in: Nanomedicine : nanotechnology, biology, and medicine, Vol. 10, Issue 7, pp. 1497-506, (2014) (PubMed).

Pan, Lin, Ma, Shen, Schachner: "Major vault protein promotes locomotor recovery and regeneration after spinal cord injury in adult zebrafish." in: The European journal of neuroscience, Vol. 37, Issue 2, pp. 203-11, (2013) (PubMed).

Rahimi, Wilson, Saylor, Stelow, Thomas, Reibel, Levine, Shonka, Jameson, Read: "p16, Cyclin D1, and HIF-1? Predict Outcomes of Patients with Oropharyngeal Squamous Cell Carcinoma Treated with Definitive Intensity-Modulated Radiation Therapy." in: International journal of otolaryngology, Vol. 2012, pp. 685951, (2012) (PubMed).

Wang, Subramanian, Lu, Howatt, Moorleghen, Charnigo, Cassis, Daugherty: "Deficiency of receptor-associated protein attenuates angiotensin II-induced atherosclerosis in hypercholesterolemic mice without influencing abdominal aortic aneurysms." in: Atherosclerosis, Vol. 220, Issue 2, pp. 375-80, (2012) (PubMed).

Dortet, Mostowy, Samba-Louaka, Louaka, Gouin, Nahori, Wiemer, Dussurget, Cossart: "Recruitment of the major vault protein by InlK: a Listeria monocytogenes strategy to avoid autophagy." in: PLoS pathogens, Vol. 7, Issue 8, pp. e1002168, (2011) (PubMed).

Hu, Peng, Li: "The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer." in: Journal of experimental & clinical cancer research : CR, Vol. 28, pp. 144, (2009) (PubMed).

Synonyms and alternative names related to MVP

major vault protein (MVP), major vault protein (Mvp), major vault protein (mvp), major vault protein L homeolog (mvp.L), major vault protein (Tc00.1047053510353.10), major vault protein (Tb927.5.4460), major vault protein (Tb10.70.0520), major vault protein (Tb10.70.5840), putative major vault protein (LMJF_05_0060), 2310009M24Rik, cb771, LRP, MGC145641, mvp, Tb05.45E22.810, VAULT1, wu:fb52b05, wu:fc02g01

Protein level used designations for MVP

  • lung resistance-related protein
  • major vault protein
  • lung resistance-associated protein
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