anti-Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) Antibodies

MAN2B1 encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Additionally we are shipping Mannosidase, Alpha, Class 2B, Member 1 Proteins (10) and Mannosidase, Alpha, Class 2B, Member 1 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MAN2B1 17159 O09159
Anti-Rat MAN2B1 MAN2B1 361378  
MAN2B1 4125 O00754
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Top anti-Mannosidase, Alpha, Class 2B, Member 1 Antibodies at antibodies-online.com

Showing 7 out of 13 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Mouse Rabbit Un-conjugated WB Western blot analysis of extracts of mouse liver cells, using MAN2B1 antibody. 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg 13 to 16 Days
$350.00
Details
Human Rabbit Un-conjugated WB Western Blot analysis of MAN2B1 expression in transfected 293T cell line by MAN2B1 MaxPab polyclonal antibody.Lane 1: MAN2B1 transfected lysate(113.70 KDa).Lane 2: Non-transfected lysate. MAN2B1 MaxPab rabbit polyclonal antibody. Western Blot analysis of MAN2B1 expression in HepG2. 100 μg 11 to 12 Days
$425.71
Details
Human Mouse Un-conjugated WB Western Blot analysis of MAN2B1 expression in transfected 293T cell line by MAN2B1 MaxPab polyclonal antibody.Lane 1: MAN2B1 transfected lysate(111.21 KDa).Lane 2: Non-transfected lysate. 50 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IF/ICC, IHC, IP, WB Western blot analysis of the recombinant protein. IHC-P analysis of Human Tissue, with DAB staining. 100 μg 71 Days
$440.62
Details
Human Rabbit Un-conjugated WB   100 μL 13 to 14 Days
$393.25
Details
Human Mouse Un-conjugated IF/ICC, IHC, IP, WB   200 μg 11 to 18 Days
$454.83
Details

More Antibodies against Mannosidase, Alpha, Class 2B, Member 1 Interaction Partners

Mouse (Murine) Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) interaction partners

  1. Mannose receptor (-/-) liver sinusoidal endothelial cells had markedly and significantly reduced enzyme activities for four out of five lysosomal enzymes tested, i.e., cathepsin-D, alpha-mannosidase, beta-hexosaminidase and arylsulfatase.

Human Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) interaction partners

  1. A novel heterozygous mutation (c.2013G>A; p.R638H) of MANBA was identified in patients with autosomal-dominant nystagmus. An additional mutation (c.2346T>A; p.L749H) in MANBA was found by screening patients with sporadic nystagmus.

  2. Our results indicate a correlation between the MAN2B1 genotypes and the cognitive function, upper limb coordination, balance, FVC% and the storage of oligosaccharides in CSF.

  3. The results showed that the alpha-mannosidosis patient has compound heterozygous mutations in the MAN2B1 gene

  4. MAN2B1 is targeted to the vacuole without passing through the Golgi complex.

  5. A single nucleotide polymorphism in MAN2B, rs228614, is associated with risk for multiple sclerosis.

  6. Expressed MAN2B1 and MAN2B2 in Drosophila S2 cells and functionally characterized them. MAN2B1 and MAN2B2 were significantly inhibited by the class II alpha-mannosidase inhibitors, swainsonine and mannostatin A.

  7. 5 new mutations were found in the MAN2B1 gene: c.157G>T, c.562C>T, c.599A>T, c.293dupA, c.2402G>A (p.E53X, p.R188X, p.H200L, p.Y99VfsX61, p.G801D). p.H200L could involve the catalytic mechanism. p.G801D would affect correct folding.

Cow (Bovine) Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) interaction partners

  1. a previously undetected mechanism of low-pH activation and a role in lysosomal transport

Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) Antigen Profile

Protein Summary

This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MAN2B1

  • mannosidase alpha class 2B member 1 (MAN2B1) antibody
  • mannosidase, alpha, class 2B, member 1 (man2b1) antibody
  • mannosidase 2, alpha B1 (Man2b1) antibody
  • mannosidase alpha class 2B member 1 (Man2b1) antibody
  • mannosidase, alpha, class 2B, member 1 (Man2b1) antibody
  • AW107687 antibody
  • Laman antibody
  • MANB antibody

Protein level used designations for MAN2B1

mannosidase, alpha, class 2B, member 1 , lysosomal alpha-mannosidase (109.3 kD) (XF355) , lysosomal alpha-mannosidase , lysosomal alpha-mannosidase-like , lysosomal acid alpha-mannosidase , mannosidase alpha class 2B member 1 , mannosidase alpha-B , mannosidase 2, alpha B1 , mannosidase, alpha B, lysosomal , laman

GENE ID SPECIES
484932 Canis lupus familiaris
779924 Xenopus (Silurana) tropicalis
100010377 Monodelphis domestica
100174476 Pongo abelii
100395073 Callithrix jacchus
100598622 Nomascus leucogenys
17159 Mus musculus
100718205 Cavia porcellus
361378 Rattus norvegicus
4125 Homo sapiens
282272 Bos taurus
493697 Felis catus
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