anti-Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Antibodies

Human Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. miR-675-5' induces expression of MMP1 and MMP13.

2. MMP13 potentiates the effects of the ETV4 oncogene during breast cancer genesis and progression.

3. Overexpressing of GOLM1 markedly promoted the tumorigenicity and metastasis of BC cells in vivo, whereas knock-down of GOLM1 caused the opposite outcomes. Results proved that GOLM1 promoted BC cell aggressiveness by regulating matrix metalloproteinase-13 (MMP13).

4. TSP-2 regulates cell mobility through MMP-13 expression in lung cancer cells.

5. MMP13 transcription in chondrocytes is regulated by RUNX2 and depends on the DNA methylation of the RUNX2 promoter.

6. These findings identified a novel function of IRF-8 in regulating articular cartilage matrix destruction by promoting the expression of MMP-13.

7. MMP-13 plays a critical role in the shedding/cleavage of PD-L1 in the human head and neck squamous cell carcinoma.

8. MMP-2 promoted and MMP-13 disrupted vasculogenic mimicry formation in large cell lung cancer by cleaving laminin-5 to influence EGFR signal activation.

9. Data suggest that matrix metalloproteinase 13 (MMP-13) and its regulatory networks are suitable targets for the development of effective early treatment strategies for osteoarthritis (OA).

10. our results indicated that IL-1beta treatment resulted in a significant increase in expression of the transcriptional factor interferon regulatory factor-1 (IRF-1) at both the mRNA and protein levels, which was significantly ameliorated by treatment with Nebivolol. The combination of these findings suggests that Nebivolol can potentially be applied in human osteoarthritis treatment

11. High Expressions of MMP-13 is associated with degenerative knee osteoarthritis.

12. One important finding of the present study was that MMP-3 appears to be involved solely in early-onset preeclampsia, but not in late-onset preeclampsia. Higher levels of MMP-2 and MMP-13 and lower levels of MMP-9 seem to be related to both early- and late-onset severe preeclampsia.

13. Transfection of cells with either miR-100 or miR-125b negated the induction of MMP13 release. Additionally, AR activation induced a morphological alteration of MDA-MB-453 cells, which was blocked by miR-125b only.

14. ATM could be activated by lung cancer-associated TNF-alpha, up-regulate MMP-13 expression and thereby augment tumor metastasis

15. The Sp1-mediaded allelic regulation of MMP13 expression by an esophageal squamous cell carcinoma susceptibility SNP rs2252070 has been demonstrated.

16. MMP-13 IRS represents a suitable method to assess pathologic grade of precancerous and cancerous colorectal lesions. MMP-13 has been identified as an excellent marker of high grade IEN and CRC, and may thus be applied for prognostic stratification.

17. These findings suggest that using MMP-13 inhibitors in diffuse group might contribute to the control of tumor growth

18. The present results suggested that Icariin may have a chondroprotective effect, exerted through the inhibition of MMP1, MMP3 and MMP13 via MAPK pathways. Therefore, Icariin may have potential as a novel therapeutic strategy for the treatment of osteoarthritis.

19. MMP-13 may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 is a key modulator of extracellular levels of MMP-13 and its internalization is independent of the levels of ADAMTS-4, -5 and TIMP-3.

20. proteolysis of collagen-rich natural extracellular matrix (ECM), performed uniquely by individual homologous proteases, leads to distinct events that eventually affect overall ECM morphology, viscoelastic properties, and molecular composition.

Mouse (Murine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. MMP1-PAR1 signaling system drives chronic inflammatory signaling in plaques and the progression of atherosclerosis.

2. FOXO3a activation induces vascular smooth muscle cell apoptosis and extracellular matrix breakdown, in part, because of transcriptional activation of MMP13. FOXO3a activation promotes atherosclerosis and medial degeneration and increases neointima after injury that is partly dependent on MMP13.

3. Overexpression of Dlx2 enhances early chondrocyte differentiation by increasing accumulation of Col2alpha1, type II collagen and aggrecan, but interferes later stages of chondrocyte differentiation through inhibiting MMP13 expression.

4. Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer.

5. Estrogen-related receptor gamma (ERRgamma) overexpression in chondrocytes directly upregulates matrix metalloproteinase (MMP)-3 and MMP13, which are known to play crucial roles in cartilage destruction in osteoarthritis (OA).

6. Infection with Mycobacterium bovis results in increase in interleukin-1alpha, TGF-beta1, and MMP1 in multinucleated macrophages.

7. MMP-2 promoted and MMP-13 disrupted vasculogenic mimicry formation in large cell lung cancer by cleaving laminin-5 to influence EGFR signal activation.

8. The data demonstrate that MMP13 and CTGF play a crucial role in modulation of fibrogenic mediators while promoting hepatic fibrogenesis.

9. CXCL10 has strong inhibitory effects on neovascularization, whereas MMP13 is required for neovascularization in C. albicans-infected corneas.

10. that MMP-13 is a central protease in infarct development and cortical remodeling during post-stroke neurorepair

11. the phenotype seen in the Hdac4(-/-) mice is partially derived from elevation in MMP-13 and may be due to a bone remodeling disorder caused by overexpression of this enzyme.

12. MEF2C is necessary for Mmp13 gene expression at the transcriptional level and participates in PTH-stimulated Mmp13 gene expression by increased binding to c-FOS at the AP-1 site in the Mmp13 promoter.

13. data reveal a novel involvement of MMP-13 in regulating dendritic cell (DC) immunobiology through moderating MHC-I surface presentation, endocytosis and cytokine/chemokine secretion; furthermore, the reduced MHC-I surface presentation by DCs resulted in a poor CD8(+) T-cell response in vitro; MMP-13 might be a promising target for therapeutic intervention in inflammatory diseases

14. The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 and matrix metalloproteinase 13.

15. Postnatal chondrocyte-specific deletion of Hdac3 with an inducible Col2a1-Cre caused premature production of pErk1/2 and Mmp13 in the growth plate.

16. Mmp13 is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH, and Osterix through distal enhancers.

17. Our study contributes to the understanding of the role of HIF1alpha in OA and highlights the HIF1alpha-beta-catenin interaction, thus providing new insights into the impact of hypoxia in articular cartilage.

18. Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1/protease-activated receptor-1 axis may play a role in neurogenesis following physiological and/or pathological stimuli.

19. IL-1Ra is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 signaling cascade.

20. We reveal a novel role of AP-2epsilon in the regulation of gene expression in articular chondrocytes, as well as in osteoarthritis development, through modulation of Mmp13 expression and activity.

Cow (Bovine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. p38 phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

2. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

3. MMP-13 treatment of fresh articular cartilage results in cleaved fibromodulin fragments

4. increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 and MMP-13 (follicular apex vs. base) for the preovulatory collagenolysis required for follicle rupture

5. involvement of p38 MAP kinase in the hyaluronan oligosaccharide induction of MMP-13

6. MMP-13 and collagenase have roles in chondrocyte hypertrophy induced by type II collagen

7. At high but naturally occurring concentrations the collagen peptide CB12-II induced an increase in the expressions of MMP-13 and cleavage of type II collagen by collagenase in the mid zone and also in the superficial zone.

Zebrafish Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 and Mmp13.

2. Zebra fish embryogenesis requires MMP-13 and dexamethasone and hydrocortisone modulate the expression of this gene, leading to increased activity and potentially contributing to subsequent dysmorphogenesis.

3. JNK-Mmp13 signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo

Xenopus laevis Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. XCL3 and XCL4 can be differentially induced by prolactin and thyroid hormone(3)

Rabbit Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. There were clear time-dependent degenerative changes in the histology of the medial meniscus after PCL rupture. The high expression of TIMP-1, MMP-1 and MMP-13 in the cartilage may be responsible for the degeneration, and PCL rupture may trigger meniscus degradation and ultimately osteoarthritis

2. These results suggest that PEP-1-SIRT2 promotes matrix metalloproteinases-induced dedifferentiation via ERK signaling in articular chondrocytes.

3. the total content and active forms of matrix metalloproteinases (MMPs)-1, -3, and -13 was measured to assess the potential role of the mechanical environment in regulation of matrix turnover by ligament fibroblasts.

4. chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.

5. Leptin can induce MMP-13 and have a synergistic induction effect on NO with TNF-alpha in rabbit articular chondrocytes in vitro.

Horse (Equine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. The DNA microarray analysis for matrix metalloproteinase (MMP)-related mRNA expression in equine superficial digital flexor tendinitis indicated that mRNA level of MMP-13 was apparently up-regulated in the tendinitis as compared to normal tendon.

Pig (Porcine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. TNF-alpha induced MMP-13 expression by condylar cells might be involved in the degradation of the juvenile condyle.