anti-Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Antibodies

Human Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. Transfection of cells with either miR (show MLXIP Antibodies)-100 or miR (show MLXIP Antibodies)-125b negated the induction of MMP13 release. Additionally, AR activation induced a morphological alteration of MDA-MB-453 cells, which was blocked by miR (show MLXIP Antibodies)-125b only.

2. ATM (show ATM Antibodies) could be activated by lung cancer-associated TNF-alpha (show TNF Antibodies), up-regulate MMP-13 expression and thereby augment tumor metastasis

3. The Sp1 (show PSG1 Antibodies)-mediaded allelic regulation of MMP13 expression by an esophageal squamous cell carcinoma susceptibility SNP rs2252070 has been demonstrated.

4. MMP-13 IRS (show IARS Antibodies) represents a suitable method to assess pathologic grade of precancerous and cancerous colorectal lesions. MMP-13 has been identified as an excellent marker of high grade IEN and CRC (show CALR Antibodies), and may thus be applied for prognostic stratification.

5. These findings suggest that using MMP-13 inhibitors in diffuse group might contribute to the control of tumor growth

6. The present results suggested that Icariin may have a chondroprotective effect, exerted through the inhibition of MMP1 (show MMP1 Antibodies), MMP3 (show MMP3 Antibodies) and MMP13 via MAPK (show MAPK1 Antibodies) pathways. Therefore, Icariin may have potential as a novel therapeutic strategy for the treatment of osteoarthritis.

7. MMP-13 may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 (show LRP1 Antibodies) is a key modulator of extracellular levels of MMP-13 and its internalization is independent of the levels of ADAMTS-4 (show ADAMTS4 Antibodies), -5 and TIMP-3 (show TIMP3 Antibodies).

8. proteolysis of collagen-rich natural extracellular matrix (ECM (show MMRN1 Antibodies)), performed uniquely by individual homologous proteases, leads to distinct events that eventually affect overall ECM (show MMRN1 Antibodies) morphology, viscoelastic properties, and molecular composition.

9. A strong association between the -77 MMP-13 polymorphism and posterior tibial tendinopathy insufficiency.

10. Data show that AJUBA (show AJUBA Antibodies) upregulated MMP10 (show MMP10 Antibodies) and MMP13 expression in esophageal squamous cell carcinoma (ESCC).

Mouse (Murine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. that MMP-13 is a central protease in infarct development and cortical remodeling during post-stroke neurorepair

2. the phenotype seen in the Hdac4 (show HDAC5 Antibodies)(-/-) mice is partially derived from elevation in MMP-13 and may be due to a bone remodeling disorder caused by overexpression of this enzyme.

3. MEF2C (show MEF2C Antibodies) is necessary for Mmp13 gene expression at the transcriptional level and participates in PTH (show PTH Antibodies)-stimulated Mmp13 gene expression by increased binding to c-FOS at the AP-1 (show JUN Antibodies) site in the Mmp13 promoter.

4. data reveal a novel involvement of MMP-13 in regulating dendritic cell (DC) immunobiology through moderating MHC-I surface presentation, endocytosis and cytokine/chemokine (show CCL1 Antibodies) secretion; furthermore, the reduced MHC-I surface presentation by DCs resulted in a poor CD8 (show CD8A Antibodies)(+) T-cell response in vitro; MMP-13 might be a promising target for therapeutic intervention in inflammatory diseases

5. The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2 (show DDR2 Antibodies)-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 (show DDR2 Antibodies) and matrix metalloproteinase 13.

6. Postnatal chondrocyte-specific deletion of Hdac3 (show HDAC3 Antibodies) with an inducible Col2a1 (show COL2A1 Antibodies)-Cre caused premature production of pErk1/2 and Mmp13 in the growth plate.

7. Mmp13 is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (show PTH Antibodies), and Osterix (show SP7 Antibodies) through distal enhancers.

8. Our study contributes to the understanding of the role of HIF1alpha (show HIF1A Antibodies) in OA and highlights the HIF1alpha (show HIF1A Antibodies)-beta-catenin (show CTNNB1 Antibodies) interaction, thus providing new insights into the impact of hypoxia in articular cartilage.

9. Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1 (show MMP1 Antibodies)/protease-activated receptor-1 (show F2R Antibodies) axis may play a role in neurogenesis following physiological and/or pathological stimuli.

10. IL-1Ra (show IL1RN Antibodies) is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 (show IL1A Antibodies) signaling cascade.

Cow (Bovine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. p38 (show MAPK14 Antibodies) phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

2. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

3. MMP-13 treatment of fresh articular cartilage results in cleaved fibromodulin (show FMOD Antibodies) fragments

4. increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 (show MMP1 Antibodies) and MMP-13 (follicular apex (show APEX1 Antibodies) vs. base) for the preovulatory collagenolysis required for follicle rupture

5. involvement of p38 MAP kinase (show MAPK14 Antibodies) in the hyaluronan oligosaccharide induction of MMP-13

6. MMP-13 and collagenase have roles in chondrocyte hypertrophy induced by type II collagen (show COL2A1 Antibodies)

7. At high but naturally occurring concentrations the collagen peptide CB12 (show PABPC4 Antibodies)-II induced an increase in the expressions of MMP-13 and cleavage of type II collagen (show COL2A1 Antibodies) by collagenase in the mid zone and also in the superficial zone.

Xenopus laevis Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. XCL3 and XCL4 can be differentially induced by prolactin (show PRL Antibodies) and thyroid hormone (show PTH Antibodies)(3)

Zebrafish Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 (show MMP9 Antibodies) and Mmp13.

2. Zebra fish embryogenesis requires MMP-13 and dexamethasone and hydrocortisone modulate the expression of this gene, leading to increased activity and potentially contributing to subsequent dysmorphogenesis.

3. JNK (show MAPK8 Antibodies)-Mmp13 signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo

Rabbit Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. These results suggest that PEP-1-SIRT2 (show SIRT2 Antibodies) promotes matrix metalloproteinases-induced dedifferentiation via ERK (show MAPK1 Antibodies) signaling in articular chondrocytes.

2. chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 (show MMP3 Antibodies) and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.

3. Leptin (show LEP Antibodies) can induce MMP-13 and have a synergistic induction effect on NO with TNF-alpha (show TNF Antibodies) in rabbit articular chondrocytes in vitro.

Horse (Equine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. The DNA microarray analysis for matrix metalloproteinase (MMP)-related mRNA expression in equine superficial digital flexor tendinitis indicated that mRNA level of MMP-13 was apparently up-regulated in the tendinitis as compared to normal tendon.

Pig (Porcine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. TNF-alpha (show TNF Antibodies) induced MMP-13 expression by condylar cells might be involved in the degradation of the juvenile condyle.