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The protein encoded by MKL1 interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation.
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Human Polyclonal MKL1 Primary Antibody for ICC, IF - ABIN4334827
Schmidt, Duncan, Yadav, Regan, Verone, Lohse, Pop, Attwood, Wilding, Mohler, Sebo, Tindall, Heemers: RhoA as a mediator of clinically relevant androgen action in prostate cancer cells. in Molecular endocrinology (Baltimore, Md.) 2012
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The data identify the GEF (show SLC2A4RG Antibodies) Bcr (show BCR Antibodies) as a regulator of RhoA (show RHOA Antibodies)/MAL signaling in keratinocytes, which in turn promotes differentiation through the desmosomal cadherin Dsg1 (show DSG1 Antibodies).
the tumor suppressive role of miR (show MLXIP Antibodies)-219a-5p in regulating breast cancer migration by targeting MRTF-A.
HDAC4 (show HDAC4 Antibodies) stimulates MRTF-A expression and drives fibrogenesis in hepatic stellate cells by targeting miR (show MLXIP Antibodies)-206
MRTF-A is required for proliferation and formation of mammary acini from luminal epithelial cells. Conversely, elevated MRTF activity results in pre-malignant spheroid formation due to defective proliferation, polarity loss and epithelial-mesenchymal transition.
MRTF-A regulated the transcriptional activity of Nrf2 (show GABPA Antibodies) by forming a complex with SRF binding to the CarG box which existed on Nrf2 (show GABPA Antibodies) promoter region, increasing the resistance of tumor cells to doxorubicin.
Among a group of tumor cells, there is correlation between activation of the MRTF-dependent transcription and activated FAK (show PTK2 Antibodies)-dependent regulation of cell migration.
The identification of the miR (show MLXIP Antibodies)-206/TWF1 (show TWF1 Antibodies)/MKL1-SRF/IL11 (show IL11 Antibodies) signaling pathway sheds lights on the understanding of breast cancer initiation and progression, unveils new therapeutic targets, and facilitates innovative drug development to control cancer and block metastasis
Herein, we propose a new ILK (show ILK Antibodies)-MMP9 (show MMP9 Antibodies)-MRTF axis that appears to be critical for endothelial-mesenchymal transition differentiation of endothelial to cancer-associated fibroblasts -like cells. Thus, it might be an attractive target for cancer treatment
CytoD modified MKL1, a coactivator of serum response factor (SRF) regulating CTGF induction, and promoted its nuclear localization.
HOTAIR is regulated by the RhoC-MRTF-A-SRF signaling pathway in breast cancer cells.
beta-catenin (show CTNNB1 Antibodies) controls myocardin (show MYOCD Antibodies)-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes.
Study have demonstrated a stress-dependent p38MAPK (show MAPK14 Antibodies)/MK2 (show KCNA2 Antibodies)-driven phosphorylation of two defined, well conserved serine residues of MRTF-A in various cultured cell lines as well as in vitro. These observation suggests that the modulation of MRTF-A activity by MK2 (show KCNA2 Antibodies)-mediated phosphorylation could represent a novel crosstalk between myogenic and stress signaling.
these data indicate that Emerin (show EMD Antibodies), a conserved nuclear lamina protein, couples extracellular matrix mechanics and SRF-Mkl1-dependent transcription.
Here, the authors show that Rho-dependent MRTF phosphorylation reflects its nuclear accumulation and dissociation from G-actin (show ACTB Antibodies), and identify multiple sites for MRTF phosphorylation, which contribute to transcriptional activation.
BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.
knockdown of MKL1 induces a significant increase in the transcriptional activity of PPARgamma (show PPARG Antibodies) target genes and MKL1 interacts with PPARg (show PPARG Antibodies), suggesting that SRF and MKL1 independently inhibit brown adipogenesis and that MKL1 exerts its effect mainly by modulating PPARgamma (show PPARG Antibodies) activity
further found that hypericin ameliorates inflammatory response by suppressing MKL1, which is the essential cofactor of p65 (show NFkBP65 Antibodies) during the transcription process. In an Abeta (show APP Antibodies) injection AD mouse model, animals orally administrated hypericin (50 mg/kg) for seven days significantly decreased pro-inflammatory cytokines expression and NO production in hippocampus, meanwhile, hypericin improved oAbeta42-induced learning and memory...
Study demonstrates that WH2 domains activate MRTF-A and contribute to target gene regulation by a competitive mechanism, independently of their role in actin filament formation.
The transcriptional co-activator MRTF-A was activated by sphingosine-1-phosphate as assessed by its nuclear accumulation and induction of a RhoA (show RHOA Antibodies)/MRTF-A luciferase reporter.
MRTF-A regulates liver fibrosis by epigenetically tuning the TGF-beta (show TGFB1 Antibodies) signaling pathway in HSCs
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.
megakaryoblastic leukemia 1 protein
, MKL/myocardin-like protein 1
, RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein
, basic, SAP and coiled-coil domain
, megakaryocytic acute leukemia protein
, myocardin-related transcription factor A
, basic SAP and coiled-coil domains
, basic SAP coiled-coil transcription activator
, megakaryoblastic leukemia (translocation) 1 homolog
, megakaryoblastic leukemia 1 protein homolog