anti-Megakaryoblastic Leukemia (Translocation) 1 (MKL1) Antibodies

The protein encoded by MKL1 interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation.

list all antibodies Gene Name GeneID UniProt
Anti-Human MKL1 MKL1 57591 Q969V6
Anti-Rat MKL1 MKL1 315151  
Anti-Mouse MKL1 MKL1 223701 Q8K4J6
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Top anti-MKL1 Antibodies at antibodies-online.com

Showing 10 out of 88 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: Mkl1 Antibody [NBP1-88498] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli. Immunohistochemistry-Paraffin: Mkl1 Antibody [NBP1-88498] - Immunohistochemical staining of human placenta shows strong nuclear positivity in decidual cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-MKL1 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:1562500  Positive Control:  NIH/3T3 cell lysate Host:  Rabbit  Target Name:  MKL1  Sample Tissue:  Mouse Spleen  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$229.00
Details
Mouse Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc/HeLa cells, using MKL1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB Immunohistochemistry of paraffin-embedded mouse brain using MKL1 antibody. Immunohistochemistry of paraffin-embedded rat brain using MKL1 antibody. 100 μL Log in to see 16 Days
$334.02
Details
Cow Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti Mkl1/MRTF-A Polyclonal Antibody, Unconjugated (ABIN1387286) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse lung labeled with Rabbit Anti Mkl1/MRTF-A Polyclonal Antibody, Unconjugated (ABIN1387286) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$306.90
Details
Human Rabbit Un-conjugated WB MKL1 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MKL1 antibody detected the MKL1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis in CEM cell line lysates (35ug/lane). 400 μL Log in to see 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated IHC (p), WB <b>Western blot</b> (WB) analysis of MRTF-A antibody in extracts from HUVEC cells. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details

Top referenced anti-MKL1 Antibodies

  1. Human Polyclonal MKL1 Primary Antibody for ICC, IF - ABIN4334827 : Schmidt, Duncan, Yadav, Regan, Verone, Lohse, Pop, Attwood, Wilding, Mohler, Sebo, Tindall, Heemers: RhoA as a mediator of clinically relevant androgen action in prostate cancer cells. in Molecular endocrinology (Baltimore, Md.) 2012 (PubMed)
    Show all 5 Pubmed References

More Antibodies against MKL1 Interaction Partners

Human Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. The data identify the GEF (show SLC2A4RG Antibodies) Bcr (show BCR Antibodies) as a regulator of RhoA (show RHOA Antibodies)/MAL signaling in keratinocytes, which in turn promotes differentiation through the desmosomal cadherin Dsg1 (show DSG1 Antibodies).

  2. the tumor suppressive role of miR (show MLXIP Antibodies)-219a-5p in regulating breast cancer migration by targeting MRTF-A.

  3. HDAC4 (show HDAC4 Antibodies) stimulates MRTF-A expression and drives fibrogenesis in hepatic stellate cells by targeting miR (show MLXIP Antibodies)-206

  4. MRTF-A is required for proliferation and formation of mammary acini from luminal epithelial cells. Conversely, elevated MRTF activity results in pre-malignant spheroid formation due to defective proliferation, polarity loss and epithelial-mesenchymal transition.

  5. MRTF-A regulated the transcriptional activity of Nrf2 (show GABPA Antibodies) by forming a complex with SRF binding to the CarG box which existed on Nrf2 (show GABPA Antibodies) promoter region, increasing the resistance of tumor cells to doxorubicin.

  6. Among a group of tumor cells, there is correlation between activation of the MRTF-dependent transcription and activated FAK (show PTK2 Antibodies)-dependent regulation of cell migration.

  7. The identification of the miR (show MLXIP Antibodies)-206/TWF1 (show TWF1 Antibodies)/MKL1-SRF/IL11 (show IL11 Antibodies) signaling pathway sheds lights on the understanding of breast cancer initiation and progression, unveils new therapeutic targets, and facilitates innovative drug development to control cancer and block metastasis

  8. Herein, we propose a new ILK (show ILK Antibodies)-MMP9 (show MMP9 Antibodies)-MRTF axis that appears to be critical for endothelial-mesenchymal transition differentiation of endothelial to cancer-associated fibroblasts -like cells. Thus, it might be an attractive target for cancer treatment

  9. CytoD modified MKL1, a coactivator of serum response factor (SRF) regulating CTGF induction, and promoted its nuclear localization.

  10. HOTAIR is regulated by the RhoC-MRTF-A-SRF signaling pathway in breast cancer cells.

Cow (Bovine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. beta-catenin (show CTNNB1 Antibodies) controls myocardin (show MYOCD Antibodies)-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes.

Mouse (Murine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. Study have demonstrated a stress-dependent p38MAPK (show MAPK14 Antibodies)/MK2 (show KCNA2 Antibodies)-driven phosphorylation of two defined, well conserved serine residues of MRTF-A in various cultured cell lines as well as in vitro. These observation suggests that the modulation of MRTF-A activity by MK2 (show KCNA2 Antibodies)-mediated phosphorylation could represent a novel crosstalk between myogenic and stress signaling.

  2. these data indicate that Emerin (show EMD Antibodies), a conserved nuclear lamina protein, couples extracellular matrix mechanics and SRF-Mkl1-dependent transcription.

  3. Among a group of tumor cells, there is correlation between activation of the MRTF-dependent transcription and activated FAK (show PTK2 Antibodies)-dependent regulation of cell migration.

  4. Here, the authors show that Rho-dependent MRTF phosphorylation reflects its nuclear accumulation and dissociation from G-actin (show ACTB Antibodies), and identify multiple sites for MRTF phosphorylation, which contribute to transcriptional activation.

  5. BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.

  6. knockdown of MKL1 induces a significant increase in the transcriptional activity of PPARgamma (show PPARG Antibodies) target genes and MKL1 interacts with PPARg (show PPARG Antibodies), suggesting that SRF and MKL1 independently inhibit brown adipogenesis and that MKL1 exerts its effect mainly by modulating PPARgamma (show PPARG Antibodies) activity

  7. further found that hypericin ameliorates inflammatory response by suppressing MKL1, which is the essential cofactor of p65 (show NFkBP65 Antibodies) during the transcription process. In an Abeta (show APP Antibodies) injection AD mouse model, animals orally administrated hypericin (50 mg/kg) for seven days significantly decreased pro-inflammatory cytokines expression and NO production in hippocampus, meanwhile, hypericin improved oAbeta42-induced learning and memory...

  8. Study demonstrates that WH2 domains activate MRTF-A and contribute to target gene regulation by a competitive mechanism, independently of their role in actin filament formation.

  9. The transcriptional co-activator MRTF-A was activated by sphingosine-1-phosphate as assessed by its nuclear accumulation and induction of a RhoA (show RHOA Antibodies)/MRTF-A luciferase reporter.

  10. MRTF-A regulates liver fibrosis by epigenetically tuning the TGF-beta (show TGFB1 Antibodies) signaling pathway in HSCs

MKL1 Antigen Profile

Protein Summary

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

Gene names and symbols associated with MKL1

  • megakaryoblastic leukemia (translocation) 1 (MKL1) antibody
  • megakaryoblastic leukemia 1 protein (mkl1) antibody
  • megakaryoblastic leukemia (translocation) 1 (Mkl1) antibody
  • megakaryoblastic leukemia (translocation) 1 S homeolog (mkl1.S) antibody
  • MKL (megakaryoblastic leukemia)/myocardin-like 1 (Mkl1) antibody
  • AI852829 antibody
  • AMKL antibody
  • AW743281 antibody
  • AW821984 antibody
  • Bsac antibody
  • Mal antibody
  • MKL1 antibody
  • Mrtf-A antibody
  • mrtfa antibody

Protein level used designations for MKL1

megakaryoblastic leukemia 1 protein , MKL/myocardin-like protein 1 , RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein , basic, SAP and coiled-coil domain , megakaryocytic acute leukemia protein , myocardin-related transcription factor A , xMRTF-A , basic SAP and coiled-coil domains , basic SAP coiled-coil transcription activator , megakaryoblastic leukemia (translocation) 1 homolog , megakaryoblastic leukemia 1 protein homolog

GENE ID SPECIES
745765 Pan troglodytes
100358994 Oryctolagus cuniculus
100510767 Anolis carolinensis
418005 Gallus gallus
57591 Homo sapiens
509011 Bos taurus
315151 Rattus norvegicus
398403 Xenopus laevis
223701 Mus musculus
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