anti-Megakaryoblastic Leukemia (Translocation) 1 (MKL1) Antibodies

The protein encoded by MKL1 interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. Additionally we are shipping and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MKL1 57591 Q969V6
MKL1 315151  
MKL1 223701 Q8K4J6
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Top anti-MKL1 Antibodies at

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Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-MKL1 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:1562500  Positive Control:  NIH/3T3 cell lysate Host:  Rabbit  Target Name:  MKL1  Sample Tissue:  Mouse Spleen  Antibody Dilution:  1.0ug/ml 100 μL 2 to 3 Days
Mouse Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc/HeLa cells, using MKL1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
Human Rabbit Un-conjugated WB Immunohistochemistry of paraffin-embedded mouse brain using MKL1 antibody. Immunohistochemistry of paraffin-embedded rat brain using MKL1 antibody. 100 μL 11 to 13 Days
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Available
Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated ELISA, ICC, IF, WB ABIN6268849 staining HuvEc by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. Western blot analysis of MKL1 expression in HeLa cell extract 100 μL 11 to 12 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti Mkl1/MRTF-A Polyclonal Antibody, Unconjugated (ABIN1387286) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse lung labeled with Rabbit Anti Mkl1/MRTF-A Polyclonal Antibody, Unconjugated (ABIN1387286) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
Human Rabbit Un-conjugated WB MKL1 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MKL1 antibody detected the MKL1 protein (arrow). 400 μL 10 to 11 Days
Human Rabbit Un-conjugated WB Western blot analysis in CEM cell line lysates (35ug/lane). 400 μL 2 to 3 Days
Human Rabbit Un-conjugated IF, IHC, IHC (p) Anti-BSAC / MKL1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100. 50 μL 11 to 14 Days

Top referenced anti-MKL1 Antibodies

  1. Human Polyclonal MKL1 Primary Antibody for ICC, IF - ABIN4334827 : Schmidt, Duncan, Yadav, Regan, Verone, Lohse, Pop, Attwood, Wilding, Mohler, Sebo, Tindall, Heemers: RhoA as a mediator of clinically relevant androgen action in prostate cancer cells. in Molecular endocrinology (Baltimore, Md.) 2012 (PubMed)
    Show all 6 Pubmed References

More Antibodies against MKL1 Interaction Partners

Human Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. Our new data identifies and important contribution of MKL1/2 to explaining the strikingly different response of VSMCs and ECs to cAMP elevation. Elucidation of these pathways promises to identify targets for specific inhibition of VSMC migration and proliferation.

  2. MKL1 induced HOTAIR transcription through direct interacted with the CArG box in the HOTAIR promoter region.

  3. Active serum response factor (SRF) along with its coactivator megakaryoblastic leukemia 1 (MKL1) binds DNA near hedgehog target genes and forms a previously unknown protein complex with the hedgehog transcription factor glioma-associated oncogene family zinc finger-1 (GLI1), causing amplification of GLI1 transcriptional activity.

  4. Disseminated cancer cells employ L1CAM to spread on capillaries and activate the mechanotransduction effectors YAP and MRTF-A, displacing resident pericytes and enabling the outgrowth of metastasis-initiating cells.

  5. Overexpression of MRTF-A promotes the proliferation and migration of A549 cells, while silent MRTF-A inhibits its proliferation and migration.

  6. The MRTF-A might be a key regulator of Doxorubicin (DOX)-induced PERP transcription in colon cancer cells.

  7. Interplay of cell-cell contacts and RhoA/MRTF-A signaling regulates cardiomyocyte identity.

  8. Taken together, these findings suggest that MKL1 and MKL2 are present at synapses and involved in dendritic spine maturation.

  9. Depletion of MRTF-A abolished the upregulation of COL1A1 in response to the TGF-beta or Wnt signaling.

  10. The data identify the GEF Bcr as a regulator of RhoA/MAL signaling in keratinocytes, which in turn promotes differentiation through the desmosomal cadherin Dsg1.

  11. the tumor suppressive role of miR-219a-5p in regulating breast cancer migration by targeting MRTF-A.

  12. HDAC4 stimulates MRTF-A expression and drives fibrogenesis in hepatic stellate cells by targeting miR-206

  13. MRTF-A is required for proliferation and formation of mammary acini from luminal epithelial cells. Conversely, elevated MRTF activity results in pre-malignant spheroid formation due to defective proliferation, polarity loss and epithelial-mesenchymal transition.

  14. MRTF-A regulated the transcriptional activity of Nrf2 by forming a complex with SRF binding to the CarG box which existed on Nrf2 promoter region, increasing the resistance of tumor cells to doxorubicin.

  15. Among a group of tumor cells, there is correlation between activation of the MRTF-dependent transcription and activated FAK-dependent regulation of cell migration.

  16. The identification of the miR-206/TWF1/MKL1-SRF/IL11 signaling pathway sheds lights on the understanding of breast cancer initiation and progression, unveils new therapeutic targets, and facilitates innovative drug development to control cancer and block metastasis

  17. Herein, we propose a new ILK-MMP9-MRTF axis that appears to be critical for endothelial-mesenchymal transition differentiation of endothelial to cancer-associated fibroblasts -like cells. Thus, it might be an attractive target for cancer treatment

  18. CytoD modified MKL1, a coactivator of serum response factor (SRF) regulating CTGF induction, and promoted its nuclear localization.

  19. HOTAIR is regulated by the RhoC-MRTF-A-SRF signaling pathway in breast cancer cells.

  20. TNF-alpha and LPS promoted the interaction between MKL1 and PCAF.

Cow (Bovine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes.

Mouse (Murine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. In conclusion, SRF andMKL1/MKL2 are essential for postnatal podocyte structure and function, likely through the maintenance of a normal actin cytoskeleton.

  2. JMY activates MRTF-SRF independently of F-actin via WH2/V-mediated competition with the RPEL region for G-actin binding in the cytoplasm

  3. MKL1, the key transcriptional co-activator of many actin cytoskeletal genes, regulates genomic accessibility and cell fate reprogramming

  4. AMPK may be a critical regulator of fibroblast activation through regulation of cytoskeleton dynamics and myocardin-related transcription factor-A nuclear translocation, promoting renal fibrosis.

  5. Study have demonstrated a stress-dependent p38MAPK/MK2-driven phosphorylation of two defined, well conserved serine residues of MRTF-A in various cultured cell lines as well as in vitro. These observation suggests that the modulation of MRTF-A activity by MK2-mediated phosphorylation could represent a novel crosstalk between myogenic and stress signaling.

  6. these data indicate that Emerin, a conserved nuclear lamina protein, couples extracellular matrix mechanics and SRF-Mkl1-dependent transcription.

  7. Among a group of tumor cells, there is correlation between activation of the MRTF-dependent transcription and activated FAK-dependent regulation of cell migration.

  8. Here, the authors show that Rho-dependent MRTF phosphorylation reflects its nuclear accumulation and dissociation from G-actin, and identify multiple sites for MRTF phosphorylation, which contribute to transcriptional activation.

  9. BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.

  10. knockdown of MKL1 induces a significant increase in the transcriptional activity of PPARgamma target genes and MKL1 interacts with PPARg, suggesting that SRF and MKL1 independently inhibit brown adipogenesis and that MKL1 exerts its effect mainly by modulating PPARgamma activity

  11. further found that hypericin ameliorates inflammatory response by suppressing MKL1, which is the essential cofactor of p65 during the transcription process. In an Abeta injection AD mouse model, animals orally administrated hypericin (50 mg/kg) for seven days significantly decreased pro-inflammatory cytokines expression and NO production in hippocampus, meanwhile, hypericin improved oAbeta42-induced learning and memory...

  12. Study demonstrates that WH2 domains activate MRTF-A and contribute to target gene regulation by a competitive mechanism, independently of their role in actin filament formation.

  13. The transcriptional co-activator MRTF-A was activated by sphingosine-1-phosphate as assessed by its nuclear accumulation and induction of a RhoA/MRTF-A luciferase reporter.

  14. MRTF-A regulates liver fibrosis by epigenetically tuning the TGF-beta signaling pathway in HSCs

  15. Exploration of the molecular causes of enhanced cardiac hypertrophy revealed significant activation of beta-catenin/GSK-3beta signaling, whereas MAPK and MKL1/serum-response factor pathways were inhibited.

  16. MRTF-A is a critical for epithelial to mesenchymal transition and can be stereoselectively inhibited by CCG-1423.

  17. MKL1 plays a significant role in mediating the fibrotic response to bleomycin injury. Loss of MKL1 attenuated early neutrophil influx, as well as myofibroblast-mediated remodeling.

  18. MRTF-A/B depletion results in an increase in the cell surface expression of ICAM-1 and interactions between HAoECs and leukocytes

  19. knockdown of MRTF-A synthesis abolishes the systemic sclerosis myofibroblast enhanced basal contractility and synthesis of type I collagen and inhibits the matricellular profibrotic protein, connective tissue growth factor (CCN2/CTGF

  20. Either MRTF-A or MRTF-B is dispensable for cardiac development, whereas deletion of both causes a spectrum of abnormalities ranging from reduced cardiac contractility and adult onset heart failure to neonatal lethality accompanied by sarcomere disarray.

MKL1 Antigen Profile

Protein Summary

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

Gene names and symbols associated with MKL1

  • megakaryoblastic leukemia (translocation) 1 (MKL1) antibody
  • megakaryoblastic leukemia 1 protein (mkl1) antibody
  • megakaryoblastic leukemia (translocation) 1 (Mkl1) antibody
  • megakaryoblastic leukemia (translocation) 1 S homeolog (mkl1.S) antibody
  • MKL (megakaryoblastic leukemia)/myocardin-like 1 (Mkl1) antibody
  • AI852829 antibody
  • AMKL antibody
  • AW743281 antibody
  • AW821984 antibody
  • Bsac antibody
  • Mal antibody
  • MKL1 antibody
  • Mrtf-A antibody
  • mrtfa antibody

Protein level used designations for MKL1

megakaryoblastic leukemia 1 protein , MKL/myocardin-like protein 1 , RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein , basic, SAP and coiled-coil domain , megakaryocytic acute leukemia protein , myocardin-related transcription factor A , xMRTF-A , basic SAP and coiled-coil domains , basic SAP coiled-coil transcription activator , megakaryoblastic leukemia (translocation) 1 homolog , megakaryoblastic leukemia 1 protein homolog

745765 Pan troglodytes
100358994 Oryctolagus cuniculus
100510767 Anolis carolinensis
418005 Gallus gallus
57591 Homo sapiens
509011 Bos taurus
315151 Rattus norvegicus
398403 Xenopus laevis
223701 Mus musculus
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