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MKL1 Products

(Megakaryoblastic Leukemia (Translocation) 1 (MKL1))

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The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. [provided by RefSeq, Jul 2008].

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Featured MKL1 Categories

MKL1 Antibodies

High quality antibodies with extensive validation data.

Recommended MKL1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN7264553
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IF, WB
Validations
  • (2)
Cat. No. ABIN7257724
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Mouse, Pig, Rat
Application ELISA, IF (cc), IF (p), IHC (fro), IHC (p), WB
Validations
  • (2)
Cat. No. ABIN1387286
Quantity 100 μL
Datasheet Datasheet

Recommended MKL1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968520
Quantity 96 tests
Datasheet Datasheet

Recommended MKL1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093809
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3136609
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our MKL1 products

Whitson, Lee, Urman, Mirza, Yao, Brown, Li, Shankar, Fry, Atwood, Lee, Hollmig, Aasi, Sarin, Scott, Epstein, Tang, Oro: "Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas." in: Nature medicine, Vol. 24, Issue 3, pp. 271-281, (2018) (PubMed).

Gjorevski, Piotrowski, Varner, Nelson: "Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices." in: Scientific reports, Vol. 5, pp. 11458, (2015) (PubMed).

Record, Malinova, Zenner, Plagnol, Nowak, Syed, Bouma, Curtis, Gilmour, Cale, Hackett, Charras, Moulding, Nejentsev, Thrasher, Burns: "Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1." in: Blood, Vol. 126, Issue 13, pp. 1527-35, (2015) (PubMed).

Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).

Schmidt, Duncan, Yadav, Regan, Verone, Lohse, Pop, Attwood, Wilding, Mohler, Sebo, Tindall, Heemers: "RhoA as a mediator of clinically relevant androgen action in prostate cancer cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 26, Issue 5, pp. 716-35, (2012) (PubMed).

Muehlich, Hampl, Khalid, Singer, Frank, Breuhahn, Gudermann, Prywes: "The transcriptional coactivators megakaryoblastic leukemia 1/2 mediate the effects of loss of the tumor suppressor deleted in liver cancer 1." in: Oncogene, Vol. 31, Issue 35, pp. 3913-23, (2012) (PubMed).

Synonyms and alternative names related to MKL1

megakaryoblastic leukemia (translocation) 1 (MKL1), megakaryoblastic leukemia 1 protein (mkl1), megakaryoblastic leukemia (translocation) 1 (Mkl1), megakaryoblastic leukemia (translocation) 1 S homeolog (mkl1.S), MKL (megakaryoblastic leukemia)/myocardin-like 1 (Mkl1), AI852829, AMKL, AW743281, AW821984, BSAC, Bsac, MAL, Mal, MKL1, MRTF-A, Mrtf-a, mrtf-a, Mrtf-A, mrtfa

Protein level used designations for MKL1

  • megakaryoblastic leukemia 1 protein
  • MKL/myocardin-like protein 1
  • RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein
  • basic, SAP and coiled-coil domain
  • megakaryocytic acute leukemia protein
  • myocardin-related transcription factor A
  • xMRTF-A
  • basic SAP and coiled-coil domains
  • basic SAP coiled-coil transcription activator
  • megakaryoblastic leukemia (translocation) 1 homolog
  • megakaryoblastic leukemia 1 protein homolog
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