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MAGEA2 is a member of the MAGEA gene family.
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Data indicate that melanoma-associated antigen (show ZNF654 Antibodies) A2 (MAGEA2)is significantly overexpressed in triple-negative breast cancer (TNBC) tissues and is important for progression of TNBC and may serve as a novel molecular therapeutic target.
suppression of MAGEA2 in lung cancer cells significantly reduced the growth/survival of cancer cells. High-MAGEA2 was identified as an independent prognostic factor in lung adenocarcinoma. Specific inhibition of MAGEA2 may be a promising therapeutic strategy for patients with lung cancer.
Immunohistochemistry using D2-40 monoclonal antibody (MAGE2) and anti-MITF1 increased detection of lymphovascular invasion in primary cutaneous melanoma.
We find that MAGE-A2 interacts with MDM2 (show MDM2 Antibodies) via the N-terminal p53 (show TP53 Antibodies)-binding pocket and the RING finger (show PCGF1 Antibodies) domain of MDM2 (show MDM2 Antibodies) that is required for homo/hetero-dimerization and for E2 ligase interaction.
Consistent with increased cell death, the induced loss of MAGEA2 expression correlated with increased caspase 3 (show CASP3 Antibodies)/7 activity, BCL2 (show BCL2 Antibodies)/BAX (show BAX Antibodies) ratio and TUNEL signal.
MAGEA2 has a critical role in the development of tamoxifen-resistant breast cancer
MageA2 interferes with p53 (show TP53 Antibodies) acetylation at PML (show PML Antibodies)-nuclear bodies (NBs (show NBN Antibodies)) and with PMLIV-dependent activation of p53 (show TP53 Antibodies).
Report MAGEA1 (show MAGEA1 Antibodies)-A6 expression in sputum suggests presence of lung cancer cells or precancerous cells.
These data suggest that MAGEA2 is differentially expressed in HNSCC and functions, in part, through the p53 (show TP53 Antibodies) pathway by increasing cellular proliferation and abrogating cell cycle arrest.
MAGE-A2 targets p53 (show TP53 Antibodies) transactivation function through histone deacetylase (show HDAC1 Antibodies) recruitment
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
melanoma antigen family A, 2
, MAGE-2 antigen
, cancer/testis antigen 1.2
, cancer/testis antigen family 1, member 2
, melanoma antigen 2
, melanoma-associated antigen 2