anti-Mesoderm Posterior 2 Homolog (Mouse) (Mesp2) Antibodies

Mesp2 encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. Additionally we are shipping Mesp2 Proteins (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Mesp2 17293 O08574
Mesp2 55897 Q9BRJ9
Mesp2 293046  
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Top anti-Mesp2 Antibodies at antibodies-online.com

Showing 10 out of 23 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Rabbit Un-conjugated WB WB Suggested Anti-MESP2 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:62500  Positive Control:  SP2/0 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of MESP2 expression in A549 (A), NS-1 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Mouse Un-conjugated ELISA, WB 100 μg Log in to see 11 to 16 Days
$426.40
Details
Mouse Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Human Mouse Un-conjugated ELISA, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using MESP2 mAb against human MESP2 recombinant protein. (Expected MW is 31.4 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
$561.00
Details
Mouse Rabbit Un-conjugated WB Western Blot: MESP2 Antibody [NBP1-80219] - SP2/0 cell lysate, concentration 1.25ug/ml. 100 μL Log in to see 8 to 11 Days
$444.19
Details
Mouse Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 16 Days
$221.38
Details
Human Mouse Un-conjugated IF, ELISA Immunofluorescence of monoclonal antibody to MESP2 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 7 to 9 Days
$375.83
Details

Top referenced anti-Mesp2 Antibodies

  1. Human Monoclonal Mesp2 Primary Antibody for ELISA, WB - ABIN1098148 : Qiu, Zhou, Jiang, Ji, Ding, Lv, Liu, Tang, Cheng, Qiu: Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis. in Studies in health technology and informatics 2012 (PubMed)
    Show all 2 Pubmed References

  2. Mouse (Murine) Polyclonal Mesp2 Primary Antibody for WB - ABIN2779870 : Morimoto, Takahashi, Endo, Saga: The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. in Nature 2005 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Mesp2 Interaction Partners

Mouse (Murine) Mesoderm Posterior 2 Homolog (Mouse) (Mesp2) interaction partners

  1. Studies indicate that mesodermal posterior 1 (Mesp1 (show MESP1 Antibodies)) and mesodermal posterior 2 (Mesp2) double-knockout embryos exhibited defective development of the embryonic mesoderm.

  2. conclusion was supported by analyses of Mesp2 KO and Ripply1/2 double KO embryos lacking rostral and caudal (show CAD Antibodies) properties, respectively

  3. current observations of the spatiotemporal disorder of vertebral organogenesis in the Mesp2-null mice provide further insight into the pathogenesis of SCDO and STDO, and the physiological development of the axial skeleton

  4. Data demonstrate that Mesp2 is a novel component involved in the suppression of Notch (show NOTCH1 Antibodies) target genes.

  5. Data propose a novel function of Notch (show NOTCH1 Antibodies) signaling, in which a progressive oscillating wave of Notch (show NOTCH1 Antibodies) activity is translated into the rostral-caudal (show CAD Antibodies) polarity of a somite by regulating Mesp2 expression in the anterior presomitic mesoderm.

  6. A bHLH-type transcription factor, Mesp2, plays an essential role in somite segmentation in mice.

  7. Data describe the genetic interactions between Dll1 (show DLL1 Antibodies), Dll3 (show DLL3 Antibodies), Mesp2 and Psen1 (show PSEN1 Antibodies), and the roles of Dll1 (show DLL1 Antibodies)- and Dll3 (show DLL3 Antibodies)-Notch (show NOTCH1 Antibodies) pathways, with or without Psen1 (show PSEN1 Antibodies), in rostrocaudal patterning.

  8. Mesp2 is responsible for the rostro-caudal (show CAD Antibodies) patterning process itself in the anterior presomitic mesoderm, via cellular interaction.

  9. developmental protein "wavefront" is generated by suppression of Notch (show NOTCH1 Antibodies) activity by mesoderm posterior 2 (Mesp2) through induction of the lunatic fringe (show LFNG Antibodies) gene (Lfng (show LFNG Antibodies))

  10. Tbx6 (show TBX6 Antibodies) directly binds to the Mesp2 gene upstream region and mediates Notch (show NOTCH1 Antibodies) signaling, and subsequent Mesp2 transcription, in the anterior presomitic mesoderm.

Human Mesoderm Posterior 2 Homolog (Mouse) (Mesp2) interaction partners

  1. The present study firstly provided experimental evidence supporting the concept that a MESP1 (show MESP1 Antibodies) lossoffunction mutation may contribute to the development of double outlet right ventricle in humans, which presents a significant insight into the molecular pathogenesis of congenital heart disease.

  2. results suggest that pathologic variants in MESP1 (show MESP1 Antibodies) may contribute to the development of congenital heart disease (CHD (show CHDH Antibodies)) and that additional protein partners and downstream targets could likewise contribute to the wide range of causes for CHD (show CHDH Antibodies)

  3. The MESP1 (show MESP1 Antibodies)-NKX2-5 (show NKX2-5 Antibodies) hESC reporter line allows us to identify molecular cues crucial for specification and expansion of human cardiac mesoderm and early progenitors and their differentiation to specific cardiovascular derivatives.

  4. MESP1 (show MESP1 Antibodies) SNPs are associated with congenital heart disease in patients and altered transcription in vitro.

  5. Transcription factors ETS2 (show ETS2 Antibodies) and MESP1 (show MESP1 Antibodies) transdifferentiate human dermal fibroblasts into cardiac progenitors.

  6. MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population.

  7. MesP1 (show MESP1 Antibodies) drives vertebrate cardiovascular differentiation through Dkk-1 (show DKK1 Antibodies)-mediated blockade of Wnt (show WNT2 Antibodies)-signalling

  8. Mutated MESP2 causes spondylocostal dysostosis

  9. Mesp1 (show MESP1 Antibodies) is down-regulated in the later stages of development by increasing levels of Mesp2 in the wild-type embryo.

  10. findings suggest a founder-effect mutation in the MESP2 gene as a major cause of the classical Puerto Rican form of spondylothoracic dysostosis/Jarcho-Levin syndrome

Mesp2 Antigen Profile

Protein Summary

This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02).

Gene names and symbols associated with Mesp2

  • mesoderm posterior 2 (Mesp2) antibody
  • mesoderm posterior bHLH transcription factor 1 (MESP1) antibody
  • mesoderm posterior bHLH transcription factor 2 (Mesp2) antibody
  • mesoderm posterior bHLH transcription factor 2 (MESP2) antibody
  • bHLHc5 antibody
  • bHLHc6 antibody
  • SCDO2 antibody

Protein level used designations for Mesp2

mesoderm posterior protein 2 , class C basic helix-loop-helix protein 5 , mesoderm posterior protein 1 , mesoderm posterior 2 , class C basic helix-loop-helix protein 6

GENE ID SPECIES
17293 Mus musculus
55897 Homo sapiens
293046 Rattus norvegicus
100015370 Monodelphis domestica
145873 Homo sapiens
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