anti-Metal-Regulatory Transcription Factor 1 (MTF1) Antibodies

MTF1 encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. Additionally we are shipping MTF1 Proteins (8) and MTF1 Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MTF1 17764 Q07243
MTF1 4520 Q14872
MTF1 362591  
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Top anti-MTF1 Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-MTF1 Antibody Titration:  5.0ug/ml  ELISA Titer:  1:2500  Positive Control:  HepG2 cell lysate MTF1 is supported by BioGPS gene expression data to be expressed in HepG2 100 μL Log in to see 2 to 3 Days
$249.00
Details
Human Rabbit Un-conjugated ChIP, ICC, IF, IHC, IHC (fro), IHC (p), WB Immunohistochemistry-Paraffin: MTF1 Antibody [NBP1-86380] - Staining of human corpus, uterine shows strong cytoplasmic positivity in glandular cells. Immunocytochemistry/Immunofluorescence: MTF1 Antibody [NBP1-86380] - Staining of human cell line U-2 OS shows positivity in nucleus but not nucleoli. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: MTF1 Antibody [NBP1-86379] - Staining of human cell line U-251 MG shows positivity in nucleus but not nucleoli. Immunohistochemistry-Paraffin: MTF1 Antibody [NBP1-86379] - Staining of human kidney shows strong cytoplasmic positivity in cells in tubules. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Cow Rabbit Un-conjugated WB 100 μg Log in to see 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of MTF1 using Jurkat whole cell lysates 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Mouse Un-conjugated ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) . Dilution: 1:500~1000 Detection limit for recombinant GST tagged MTF1 is approximately 0.3ng/ml as a capture antibody. 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-MTF-1 Polyclonal Antibody, Unconjugated (ABIN701425) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$317.90
Details
Dog Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 16 Days
$335.04
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Liver lysate; Primary Ab: 1µg/ml Rabbit Anti-Mouse MTF1 Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) Figure. Western Blot; Sample: Recombinant protein. 100 μg Log in to see 15 to 18 Days
$360.00
Details

Top referenced anti-MTF1 Antibodies

  1. Human Polyclonal MTF1 Primary Antibody for ChIP, ICC - ABIN4335936 : Kim, Jeon, Shin, Won, Lee, Kwak, Lee, Rhee, Ryu, Chun, Chun: Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis. in Cell 2014 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal MTF1 Primary Antibody for ELISA, WB - ABIN561861 : Zhang, Meyer, Zhang: Fetal exposure to cocaine causes programming of Prkce gene repression in the left ventricle of adult rat offspring. in Biology of reproduction 2009 (PubMed)

More Antibodies against MTF1 Interaction Partners

Zebrafish Metal-Regulatory Transcription Factor 1 (MTF1) interaction partners

  1. The functional characterization of a complete zebrafish MTF-1, is reported.

  2. MTF1 is a master regulator of gene expression during development.

Mouse (Murine) Metal-Regulatory Transcription Factor 1 (MTF1) interaction partners

  1. Findings identify a reciprocal activation mechanism involving HIF-2alpha and the zinc-ZIP8-MTF1 axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction.

  2. MTF1 mediates the increase of CaV3.2 mRNA and a rise in intracellular Zn(2+) which is associated with status epilepticus.

  3. the presence of SUMO moiety allows the MTF-1 protein to interact directly with metal-responsive element

  4. nuclear receptor SHP inhibits zinc-dependent induction of Dnmt1 by antagonizing metal-responsive transcription factor-1.

  5. MTF-1 DNA-binding activity is strongly enhanced in the presence of zinc.

  6. PTEN associates with MTF-1 in cells in response to oxidative stress and in zinc homeostasis.

  7. Results reveal a novel repressive role for MTF-1 in the regulation of the Zip10 zinc transporter expression by pausing Pol II transcription.

  8. Data show that disruption of nucleosome structure at the MT-I promoter is mediated by zinc-responsive recruitment of an active MTF-1-coactivator complex.

  9. Zinc and cadmium can activate FPN1 transcription through the MTF-1.

  10. mouse MTF-1 is polymorphic

  11. Zinc finger domains 1, 3, and 6 of MTF1, in particular domains 1 and 6, show lower metal ion affinities and remain as the most likely candidates if the Cys2His2 metal ion-binding sites of MTF1 are, indeed, responsible for zinc sensing in vivo.

  12. MTF1 plays a critical role in embryonic liver formation, heavy metal toxicity, and hematopoiesis.

  13. MTF-1 enhances the ability of the developing tumor mass to evade fibrosis and scarring of the tumor, a critical step in tumor cell proliferation.

  14. Highly inducible strains having Mtf-1 of proline type are refractory to radiation effects and hence are resistant to lymphoma development.

  15. Zinc sensing by MTF-1 in eukaryotic cells involves multiple zinc fingers and occurs over a 100-fold or less range of accessible Zn(II) concentration.

  16. Together, these novel findings define a role for MTF-1 in the regulation of HIF-1 activity.

  17. New MTF-1 target genes with metal response elements motifs in the promoter region were identified.

  18. Results suggest a mechanism by which physiological concentrations of accessible cellular zinc affect MTF-1 activity.

  19. We also show that large thymocytes with higher ROS levels and a proliferation capacity were more numerous in the Mtf-1 susceptible mice than the resistant mice when examined at 7 days after irradiation.

  20. Nuclear factor-1 acts synergistically with MTF-1 to activate the mouse metallothionein-1 promoter in response to metal ions

Human Metal-Regulatory Transcription Factor 1 (MTF1) interaction partners

  1. MTF1 heads a hierarchy of zinc sensors, and through controlling the expression of a raft of metallothioneins and other key proteins involved in controlling intracellular zinc levels (e.g. ZnT1) alters zinc buffering capacity and total cellular zinc content.

  2. MTF-1 has a role in regulating zinc dependent cellular processes at the molecular level [review]

  3. Forty-one single nucleotide polymorphisms (SNPs) within the MTF1 gene region.

  4. Human ZnT2 expression is regulated by MTF-1.

  5. Zn-responsive proteome profiling and time-dependent expression of proteins are regulated by MTF-1 in human alveolar epithelial cells.

  6. The zinc-sensing cytoplasmic transcription factor MTF-1 plays a key role in cellular zinc homoeostasis.

  7. Results identify a cysteine cluster that mediates homodimerization of human MTF-1, and show that dimer formation in vivo is important for basal and especially metal-induced transcriptional activity.

  8. Variations in the ability of LAT1/DMT1/MTF1/MT1a to process and transport Hg may not play a significant role in the etiology of autism.

  9. It is concluded that SUMO conjugation and the SIM on MTF-1 do not play a critical role in suppressing transcriptional activity. Instead, MTF-1 forms complexes with cellular factors through SIM and SUMO moiety in the cytoplasm

  10. Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by metal transcription factor-1.

  11. Zinc and cadmium can activate FPN1 transcription through the MTF-1.

  12. Data show that hepcidin transcription involves interactions between functional metal response elements (MREs) in its promoter, and the MRE-binding transcription factor-1.

  13. Genetic regulation via sequences downstream of promoters highlights a new direction for identifying previously unrecognized target genes for MTF-1.

  14. Loss of LI-cadherin results in up-regulation of MTF-1 and PlGF, thereby regulating angiogenesis in intrahepatic cholangiocarcinoma

  15. role in regulating metallothionein transcription

  16. MTF1 transactivation potential is affected by chromium levels

  17. mediates transcriptional hyperactivation along with heat and heavy metal stress

  18. MTF-1 contains a cysteine-rich cluster, -632Cys-Gln-Cys-Gln-Cys-Ala-Cys638-, which appears to be specifically required for MTF-1 to activate transcription in the presence of inducing heavy metal ions.

  19. The MTF-1 serves targeted disruption of the MTF-1 gene results in death at embryonic day 14 due to liver degeneration and under hypoxic-anoxic stress, MTF-1 helps to activate the transcription of the gene PIGF.

  20. SP1 and MTF-1 represent new targets in the development of key therapeutics toward modulating the expression of the cellular prion protein and ultimately the prevention of prion disease

MTF1 Antigen Profile

Protein Summary

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).

Gene names and symbols associated with MTF1

  • metal regulatory transcription factor 1 (MTF1) antibody
  • metal-regulatory transcription factor 1 (mtf1) antibody
  • metal-regulatory transcription factor 1 L homeolog (mtf1.L) antibody
  • metal regulatory transcription factor 1 (mtf1) antibody
  • metal response element binding transcription factor 1 (Mtf1) antibody
  • metal-regulatory transcription factor 1 (Mtf1) antibody
  • MGC86485 antibody
  • MTF-1 antibody
  • mtf1 antibody
  • Thyls antibody
  • ZRF antibody

Protein level used designations for MTF1

metal regulatory transcription factor 1 , metal-regulatory transcription factor 1 , metal regulatory transcription factor 1-like , MRE-binding transcription factor , metalloregulatory transcription factor , transcription factor MTF-1 , MRE-binding transcription factor-1 , metal-responsive transcription factor 1 , zinc regulatory factor , metal response element binding transcription factor 1

GENE ID SPECIES
100054605 Equus caballus
195821 Danio rerio
428218 Gallus gallus
456766 Pan troglodytes
714795 Macaca mulatta
779158 Xenopus laevis
100218965 Taeniopygia guttata
100352804 Oryctolagus cuniculus
100457400 Pongo abelii
100480003 Ailuropoda melanoleuca
100495484 Xenopus (Silurana) tropicalis
100539531 Meleagris gallopavo
100555296 Anolis carolinensis
100620000 Monodelphis domestica
17764 Mus musculus
4520 Homo sapiens
608127 Canis lupus familiaris
509960 Bos taurus
362591 Rattus norvegicus
100511998 Sus scrofa
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