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Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. Additionally we are shipping MCRS1 Antibodies (35) and MCRS1 Kits (8) and many more products for this protein.
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Results suggest that dMCRS2 is required for loading of RNAP II complexes on the cyclin (show PCNA Proteins) gene promoters.
MSP58 downregulation suppressed the proliferation and invasion of renal cell carcinoma (show MOK Proteins) cells.
MCRS1 is phosphorylated by the Aurora-A kinase (show AURKA Proteins) in mitosis on Ser35/36.
RINT-1 (show RINT1 Proteins) interacts with MSP58 and UBF (show UBTF Proteins) within nucleoli and plays a role in ribosomal gene transcription.
The immunoreactivity score (IRS (show IARS Proteins)) of MSP58 increased with tumor grade with grade IV gliomas exhibiting the highest expression and showed a highly significant positive correlation with the Ki-67 (show MKI67 Proteins) index (r = 0.65, P < 0.001).
Suggest that MSP58 plays an important role in tumorigenesis and progression and may help predict the prognosis of gastric cancer patients.
MCRS1 overexpression induced non-small cell lung cancer proliferation through the miR (show MLXIP Proteins)-155-Rb1 (show RB1 Proteins) pathway and DNA copy-number amplification is one of the mechanisms underlying MCRS1 overexpression in non-small cell lung cancer.
MSP58 subnuclear localization is regulated by two nuclear import signals, and proper subcellular localization of MSP58 is critical for its role in transcriptional regulation. A molecular mechanism controls nuclear and nucleolar localization of MSP58.
BAP1 (show RNF2 Proteins) loss and MCRS1 down-regulation in renal cell carcinoma (show MOK Proteins) are associated with adverse clinicopathological features.
MiR (show MLXIP Proteins)-129* down-regulation induced MCRS1 overexpression.
High expression of MSP58 was also an independent unfavorable prognostic factor.
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity.
, lethal (3) rG166
, reduction in Cnn dots 5
, microspherule protein 1
, microspherule protein 1-like
, 58 kDa microspherule protein
, nucleolar protein
, INO80 complex subunit J
, INO80 complex subunit Q
, cell cycle-regulated factor (78 kDa)
, cell cycle-regulated factor p78