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Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Additionally we are shipping MAP3K9 Proteins (6) and many more products for this protein.
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Human Polyclonal MAP3K9 Primary Antibody for IHC (p), WB - ABIN392422
Strath, Georgopoulos, Kellam, Blair: Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation. in BMC genomics 2009
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Data report that MKL1 (show MKL1 Antibodies) was both sufficient and necessary for p65 (show GORASP1 Antibodies)-dependent pro-inflammatory transcriptional program. MKL1 (show MKL1 Antibodies) deficiency erased key histone modifications synonymous with transactivation on p65 (show GORASP1 Antibodies) target promoters. Specifically, MKL1 (show MKL1 Antibodies) defined histone H3K4 trimethylation landscape for NF-kappaB (show NFKB1 Antibodies) dependent transcription.
There was a negatively relationship between miR (show MLXIP Antibodies)-15a and MAP3K9 expression in NP cells.
miR148b directly targeted mitogenactivated protein kinase (show CDK7 Antibodies) (MAPK (show MAPK1 Antibodies)) kinase kinase 9 (MAP3K9), an upstream activator of MAPK (show MAPK1 Antibodies) kinase/cJun (show JUN Antibodies) Nterminal kinase (JNK (show MAPK8 Antibodies)) signaling, suppressing the protein but not the mRNA levels.
identified three kinases with gain-of-function mutations in lung cancer, namely FGFR4 (show FGFR4 Antibodies), MAP3K9, and PAK5 (show PAK6 Antibodies). Mutations in these kinases are activating toward the ERK (show EPHB2 Antibodies) pathway, and targeted depletion of the mutated kinases inhibits proliferation
It was found that 24% of melanoma cell lines have mutations in the protein-coding regions of either MAP3K5 (show MAP3K5 Antibodies) or MAP3K9.
estrogen receptor-alpha (show ESR1 Antibodies) transcriptional activity is repressed by the Rho/megakaryoblastic leukemia 1 signaling pathway
These results show that the expression of nucleosomal SRF-dependent genes, including the SMC gene, is activated by MKL1 via activation of SRF and recruitment of the FACT complex.
There is extensive functional redundancy between MLK1 and MLK2 (show MAP3K10 Antibodies), and the other member of the family, MLK3 (show KCNK7 Antibodies), none of which are required for survival in mouse.
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
mixed lineage kinase 1 (tyr and ser/thr specificity)
, mitogen activated protein kinase kinase kinase 9
, mixed-lineage kinase 1