anti-Myelin Basic Protein (MBP) Antibodies

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. Additionally we are shipping Myelin Basic Protein Proteins (42) and Myelin Basic Protein Kits (34) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MBP 4155 P02686
MBP 17196 P04370
MBP 24547 P02688
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Top anti-Myelin Basic Protein Antibodies at antibodies-online.com

Showing 10 out of 342 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Anti-Myelin Basic Protein antibody, Western blotting WB: Mouse Brain Tissue Lysate Anti-Myelin Basic Protein antibody, IHC(P) IHC(P): Rat Brain Tissue 100 μg 4 to 6 Days
$280.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-MBP Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human brain 100 μL 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated IP, IHC, WB WB Suggested Anti-MBP Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human brain IP Suggested Anti-MBP Antibody Positive Control: NT2 CELL/BRAIN TISSUE 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated IHC (fro), IF (p), IHC (p), WB Formalin-fixed and paraffin embedded: rat brain tissue labeled with Anti-MBP Polyclonal Antibody (ABIN739400), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded: rat brain tissue labeled with Anti-MBP Polyclonal Antibody (ABIN739400), Unconjugated at 1:200, followed by conjugation to the secondary antibody was Goat Anti-Rabbit IgG, PE conjugated at 1:200 for 40 minutes at 37°C DAPI(5 µg/ml, blue) was used to stain the cell nuclei 100 μL 3 to 7 Days
$329.45
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Mouse Brain Tissue. 100 μg 13 to 16 Days
$314.00
Details
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of HepG2 cells using MBP mouse mAb (green) and negative control (red) . 100 μL 3 to 4 Days
$430.10
Details
Human Mouse Un-conjugated IHC (fro), IHC (p), WB Staining of white matter in human brain with Mouse anti MBP 2 mL 6 to 8 Days
$588.50
Details
Human Rabbit Un-conjugated EIA 0.4 mL 6 to 8 Days
$484.00
Details
Cow Mouse Un-conjugated ELISA, IHC, IHC (p), RIA Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with MBP antibody ABIN462005 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with MBP antibody ABIN462005 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μg 11 to 14 Days
$484.00
Details
Human Mouse Un-conjugated ELISA, FACS, IF/ICC, IHC, WB 100 μL 11 to 16 Days
$469.05
Details

Top referenced anti-Myelin Basic Protein Antibodies

  1. Chicken Monoclonal MBP Primary Antibody for ICC, IHC (fro) - ABIN153564 : Kawai, Itoh, Itoh, Horiuchi, Wakayama, Bannerman, Garbern, Pleasure, Lindsten: Maintenance of the relative proportion of oligodendrocytes to axons even in the absence of BAX and BAK. in The European journal of neuroscience 2010 (PubMed)
    Show all 16 Pubmed References

  2. Human Polyclonal MBP Primary Antibody for IHC (p), WB - ABIN3043688 : Wang, Tu, Zhao, An, Wang, Liu, Yuan, Ahmed, Xu, Liu, Zhang, Wang: Effects of poly(L-lysine)-modified Fe3O4 nanoparticles on endogenous reactive oxygen species in cancer stem cells. in Biomaterials 2012 (PubMed)
    Show all 13 Pubmed References

  3. Human Polyclonal MBP Primary Antibody for IHC (fro), IF (p) - ABIN739400 : Liu, Chen, Liu, Yang, Xie, Zheng, Xu, Chen, Wang, Zhang, Bai, Jin: Acellular spinal cord scaffold seeded with mesenchymal stem cells promotes long-distance axon regeneration and functional recovery in spinal cord injured rats. in Journal of the neurological sciences 2013 (PubMed)
    Show all 6 Pubmed References

  4. Rat (Rattus) Monoclonal MBP Primary Antibody for ICC, IF - ABIN446359 : Pusic, Mitchell, Kunkler, Klauer, Kraig: Spreading depression transiently disrupts myelin via interferon-gamma signaling. in Experimental neurology 2015 (PubMed)
    Show all 3 Pubmed References

  5. Guinea Pig Polyclonal MBP Primary Antibody for IHC (fro) - ABIN542645 : Hauben, Agranov, Gothilf, Nevo, Cohen, Smirnov, Steinman, Schwartz: Posttraumatic therapeutic vaccination with modified myelin self-antigen prevents complete paralysis while avoiding autoimmune disease. in The Journal of clinical investigation 2001 (PubMed)
    Show all 3 Pubmed References

  6. Guinea Pig Polyclonal MBP Primary Antibody for IHC (fro) - ABIN542629 : Schwartz, Hauben: T cell-based therapeutic vaccination for spinal cord injury. in Progress in brain research 2002 (PubMed)
    Show all 3 Pubmed References

  7. Human Polyclonal MBP Primary Antibody for DB, ELISA - ABIN548702 : Boylan, Ayres, Popko, Takahashi, Hood, Prusiner: Repetitive DNA (TGGA)n 5' to the human myelin basic protein gene: a new form of oligonucleotide repetitive sequence showing length polymorphism. in Genomics 1990 (PubMed)
    Show all 3 Pubmed References

  8. Human Polyclonal MBP Primary Antibody for ELISA, ICC - ABIN259584 : Chaudhary, Marracci, Galipeau, Pocius, Morris, Bourdette: Lipoic acid reduces inflammation in a mouse focal cortical experimental autoimmune encephalomyelitis model. in Journal of neuroimmunology 2015 (PubMed)
    Show all 2 Pubmed References

  9. Human Monoclonal MBP Primary Antibody for ICC, FACS - ABIN969279 : Rajaraman, Brenner, Butler, Wang, Pfeiffer, Ruder, Linet, Yeager, Wang, Orr, Fine, Kwon, Thomas, Rothman, Inskip, Chanock: Common variation in genes related to innate immunity and risk of adult glioma. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009 (PubMed)
    Show all 2 Pubmed References

  10. Rat (Rattus) Polyclonal MBP Primary Antibody for ELISA, WB - ABIN1574105 : Kraitsy, Uecal, Grossauer, Bruckmann, Pfleger, Ropele, Fazekas, Gruenbacher, Patz, Absenger, Porubsky, Smolle-Juettner, Tezer, Molcanyi, Fasching, Schaefer: Repetitive long-term hyperbaric oxygen treatment (HBOT) administered after experimental traumatic brain injury in rats induces significant remyelination and a recovery of sensorimotor function. in PLoS ONE 2014 (PubMed)

More Antibodies against Myelin Basic Protein Interaction Partners

Human Myelin Basic Protein (MBP) interaction partners

  1. results do not support an association of the analysed SLC6A3 and MBP gene polymorphisms with PTSD in war traumatized individuals; there is a possibility for a correlation of the T allele rs12458282 within the MBP gene with higher CAPS scores in lifetime PTSD patients which would need to be tested in a sample providing more statistical power

  2. down-regulated in cord blood by prenatal smoking

  3. the interaction between the HLA-DRB1*1501 allele and MBP gene may be considered as a predisposing factor in the development and pathogenesis of multiple sclerosis in the case of gene-gene interaction

  4. PAPP-A and ProMBP are associated with increased risk of death in heart failure patients.

  5. Studied potential use of myelin basic protein (MBP) as a biomarker in CSF of brain cancer patients. Results suggest that the presence of MBP in CSF may be considered as an indicator of the brain tumor development.

  6. t-PA binds to Lys91 in the MBP NH2-terminal region and PLG binds to Lys122 in the MBP COOH-terminal region. This proximity promotes the activation of PLG by t-PA.

  7. Specific sites of post-translational modifications in multiple sclerosis patients are localized in two zones of MBP suggests that these regions may be involved in antigen recognition by the body's immune surveillance machinery

  8. Results provide novel insights into the role of genetic variation within the MBP gene predicting multiple sclerosis clinical course, both directly and by interaction with known environmental MS risk factors

  9. Pathway analysis demonstrated that the majority of the differentially expressed genes (23.3%) were involved in cytokinecytokine receptor interaction. Subsequent to GolliMBP knockdown, the mechanisms that changed the biological characteristics of Jurkat cells were complex, involving numerous types of functional proteins, and metabolic and signaling pathway

  10. Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its binding to the proteasome and decelerates its degradation by the proteasome in mammalian cells. Potential anticancer drug tetrazole analogue of chloramidine 2, at concentrations greater than 1 microM inhibits the enzymatic activity of PAD in vitro.

  11. This study observed a significantly increased myelin basic protein (MBP) and nuclear distribution protein nudE-like 1 (NDEL1) mRNA levels in FEP patients compared with controls.

  12. myelin basic protein has a role in activating CD4+ and CD8+ T lymphocytes in multiple sclerosis

  13. B cells from relapsing-remitting multiple sclerosis patients produce TNFa and IL6, and present MBP85-99 peptide

  14. IL-17- and IL-22-secreting myelin specific CD4(+) T cells resistant to corticoids are associated with radiological activity of multiple sclerosis in early stages of the disease, mainly among Afrodescendant patients who, normally, have worse prognosis.

  15. Studies indicate that all myelin basic protein (MBP) isoforms are intrinsically disordered proteins (IDPs) that interact via molecular recognition fragments (MoRFs), which thereby undergo local disorder-to-order transitions.

  16. Reduced myelin basic protein-induced CD4+ T-cell autoreactivity in interferon-beta-treated multiple sclerosis patients may be mediated by monocyte-derived interleukin-10

  17. Negatively charged actin and calmodulin (CaM), as well as basic histone H1.3, inhibit MBP hydrolysis by competing with the proteasome and MBP, respectively, for binding their counterpart.

  18. data reveal the first case of a pathophysiologically important autoantigen as a ubiquitin-independent substrate of the 26S proteasome.

  19. Single nucleotide polymorphisms on genetic loci SOD2, MBP and C8orf42were not found significantly associated with advanced age-related macular degeneration in a Chinese cohort

  20. In autistic children with allergic manifestations there were increased serum levels of MBP (and MAG) compared to those without allergies.

Mouse (Murine) Myelin Basic Protein (MBP) interaction partners

  1. Results support the formation of an amorphous protein phase of MBP between two membrane bilayers and provide a molecular model for major dense line formation during myelination, which is of importance when understanding myelin assembly and demyelinating conditions.

  2. findings suggest that the acetylation and methylation of lysine on MBP are post-translational modifications associated with the neurological disability produced by EAE.

  3. golli-KO mice display abnormal behavior including deficits in episodic memory and reduced anxiety.

  4. The Mbp(+/-) mice exhibited defects of sensorimotor gating, as evidenced by reduced prepulse-inhibition, and a late-onset catatonia phenotype.

  5. The present study provides evidence for a novel L1-mediated function of MBP in the developing spinal cord and in the injured adult mammalian nervous system that leads to enhanced recovery after acute trauma.

  6. myelin basic protein (MBP) is inhibitory to both primitive neural stem cells and definitive neural stem cells derived colony formation.

  7. CNP directly associates with and organizes the actin cytoskeleton, thereby providing an intracellular strut that counteracts membrane compaction by myelin basic protein (MBP).

  8. to further characterize the mechanism regulating mbp transcription, study defined M3 structure/function relationships; multiple M3 regulatory element combinations were found to drive expression in oligodendrocytes and Schwann cells with a minimal 129 bp sequence conferring expression in oligodendrocytes throughout myelin elaboration, maintenance and repair

  9. Results show the expression of sncRNA715 in Schwann cells and its inverse correlation with Mbp mRNA in cultured cells and the sciatic nerve. Its inhibitory effect on MBP was confirmed in differentiating primary Schwann cells.

  10. Results suggest that GAL is a regulator of myelination, as demonstrated by MBP synthesis, and may be one of the myelination promoters

  11. Data indicate that 18.5 kDa myelin basic protein (MBP) segment upstream of the primary SH3-ligand is involved in interaction.

  12. Data suggest that prenatal alterations in expression of various fetal brain proteins (including up-regulation of Mbp) are associated with aberrant behavioral characteristics of transgenic mice that model autism-like behavior.

  13. Data suggest that hybrid protein composed of two different Myelin basic protein (MBP) isoforms (TandeMBP) might become a tool for in vitro assays to analyse various protein kinase activities.

  14. Data indicate a role for myelin basic protein (MBP) isoforms in protein-protein interactions during membrane and cytoskeletal extension and remodeling in oligodendrocytes (OLGs).

  15. Disappearance of 21.5 pMBP corresponded to demyelination and its reappearance corresponded to prevention of demyelination.

  16. Golli-BG21 enhanced SCP1/GIP phosphatase activity, whereas PKCalpha-phosphorylated BG21 inhibited its activity, suggesting a potential role of BG21 as a molecular switch ("quick-brake mechanism") on SCP1/GIP.

  17. Myelin basic protein cleaves cell adhesion molecule L1 and promotes neuritogenesis and cell survival.

  18. MBP expression in cultured Fmr1 KO oligodendrocytes is similar to wild type, and expression of MBP in brain homogenates of the Fmr1 KO mouse to be similar to wild type.

  19. myelin basic protein drives myelin biogenesis using weak forces arising from its inherent capacity to phase separate.

  20. Myelin basic protein-21.5 kDa in the nucleus promotes oligodendrocyte proliferation, while melin basic protein-18.5-kDa in plasma membrane does not.

Zebrafish Myelin Basic Protein (MBP) interaction partners

  1. Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes.

Pig (Porcine) Myelin Basic Protein (MBP) interaction partners

  1. Concentrations of MBP did not increase after injury in all age groups

  2. results provide a detailed picture of the MBP-CaM interaction, including a 3D model of the complex between full-length proteins

  3. MBP-hydrolyzing antibodies may play an important role in multiple sclerosis pathogenesis

Cow (Bovine) Myelin Basic Protein (MBP) interaction partners

  1. Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its binding to the proteasome and decelerates its degradation by the proteasome in mammalian cells. Potential anticancer drug tetrazole analogue of chloramidine 2, at concentrations greater than 1 microM inhibits the enzymatic activity of PAD in vitro.

  2. Data suggest that hybrid protein composed of two different Myelin basic protein (MBP) isoforms (TandeMBP) might become a tool for in vitro assays to analyse various protein kinase activities.

  3. trehalose completely avoid autocatalytic cleavage properties of MBP up to 4 days of incubation at 37 degrees C and pH 7.4.

  4. formation of an imine between inflammatory-derived aldehydes can lead to structural changes in MBP and a decrease in myelin stability

  5. results provide a detailed picture of the MBP-CaM interaction, including a 3D model of the complex between full-length proteins

  6. MBP can induce a dihydrocholesterol-dependent segregation of phases that can be further regulated by the electrolyte concentration in the subphase and the composition (type and proportion) of non-sterol lipids.

  7. Bovine MBP priming reduces expression of Foxp3 via nitric oxide in inducible nitric oxide synthase-deficient mouse T cells.

  8. investigation of bovine myelin basic protein binding to triphosphoinositide

  9. There is a developmental regulation of posttranslationally modified forms of myelin basic protein into specific membrane microdomains.

  10. These results suggest that phospholipids and sulfatide and heparin may function as effective stimulators for autophosphorylation of GSK-3beta and for the GSK-3beta-mediated high phosphorylation of SH-binding proteins, including MBP and tau protein.

  11. Myelin basic protein (MBP), a major autoantigen in multiple sclerosis, is a potent and specific ligand for integrin alphaMbeta2 expressed mainly on phagocytic cells.

Myelin Basic Protein (MBP) Antigen Profile

Protein Summary

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Gene names and symbols associated with MBP

  • myelin basic protein (MBP) antibody
  • myelin basic protein (Mbp) antibody
  • myelin basic protein a (mbpa) antibody
  • myelin basic protein (mbp) antibody
  • myelin basic protein L homeolog (mbp.L) antibody
  • C76307 antibody
  • cb274 antibody
  • fj33b11 antibody
  • golli-mbp antibody
  • Hmbpr antibody
  • mbp antibody
  • Mbps antibody
  • MGC115135 antibody
  • mld antibody
  • R75289 antibody
  • shi antibody
  • wu:fj33b11 antibody
  • wu:fq15b02 antibody
  • zgc:136630 antibody

Protein level used designations for MBP

myelin A1 protein , myelin membrane encephalitogenic protein , myelin deficient , shiverer , Golli-Mbp; myelin basic protein , Golli-Mbp; myelin basic protein; myelin basic protein S , MBP S , myelin basic protein Golli-mbp , myelin basic protein S , myelin basic protein , Golli-mbp , 20 kDa microtubule-stabilizing protein , microtubule-stabilizing protein , Myelin A1 protein , Myelin P1 protein

GENE ID SPECIES
4155 Homo sapiens
17196 Mus musculus
24547 Rattus norvegicus
326281 Danio rerio
396217 Gallus gallus
399102 Xenopus laevis
414286 Sus scrofa
455522 Pan troglodytes
476160 Canis lupus familiaris
549346 Xenopus (Silurana) tropicalis
618684 Bos taurus
734401 Xenopus laevis
100174122 Pongo abelii
101109407 Ovis aries
100731253 Cavia porcellus
100344447 Oryctolagus cuniculus
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