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MLF1 encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Additionally we are shipping MLF1 Proteins (8) and MLF1 Kits (3) and many more products for this protein.
Showing 10 out of 120 products:
Human Polyclonal MLF1 Primary Antibody for WB - ABIN517941
Hoh, Stowe, Turk, Stearns: Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease. in PLoS ONE 2013
Human Polyclonal MLF1 Primary Antibody for WB - ABIN2785560
Li, Wu, Jiang, Liu, Wu, Inagaki, Izawa, Mizisin, Engvall, Shelton: Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice. in Journal of the neurological sciences 2007
Show all 2 Pubmed References
Mutation in HTT (show HTT Antibodies) causes Huntington's disease (HD); aggregates of mutated HTT (show HTT Antibodies) cause apoptosis in neurons of HD patients. Data suggest that both MLF1 and MLF2 preferentially interact with mutated N-terminal HTT (show HTT Antibodies); MLF1/MLF2 reduce number of neurons (Neuro2A cell line) containing mutant HTT (show HTT Antibodies) aggregates and subsequent apoptosis. (HTT (show HTT Antibodies) = Huntingtin (show HTT Antibodies) protein; MLF = myeloid leukemia (show BCL11A Antibodies) factor)
The data indicate that MLF1 serves as a proapoptotic antagonist that interacts with the HAX1 (show HAX1 Antibodies)/HtrA2-OMI (show HTRA2 Antibodies)/PARL (show PARL Antibodies) (HOP (show STIP1 Antibodies)) mitochondrial complex to modulate cell survival.
SNP associated with neuroblastoma (show ARHGEF16 Antibodies) resides upstream of the MLF1. Gene silencing of MLF1 in neuroblastoma (show ARHGEF16 Antibodies) cells results in significant growth inhibition.
Data indicte that acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)) with NPM1 (show NPM1 Antibodies)-MLF1 and AML (show RUNX1 Antibodies) with NPM1 (show NPM1 Antibodies) mutations showed similar immunophenotypical and molecular features, including gene mutation patterns and gene expression profiling (GEP (show GNA12 Antibodies)).
The subcellular localization of full-length human MLF1 is 14-3-3epsilon-independent.
changes in the subcellular localization of NPM (show NPM1 Antibodies), due to alterations in the relative abundance of NPM (show NPM1 Antibodies) and NPM (show NPM1 Antibodies)-MLF1 proteins, may contribute to the enhanced myeloid progenitor activity of Npm (show NPM1 Antibodies) +/- cells
Data present the high-resolution crystal structure of this binding motif [MLF1(29-42)pSer34] in complex with 14-3-3epsilon and analyse the interaction with isothermal titration calorimetry.
MLF1 gene rearrangement is associated with acute myeloid leukemia (show BCL11A Antibodies).
phosphorylation of 14-3-3 (show YWHAQ Antibodies) binding site by MADM (show ADAM10 Antibodies)
These findings suggest that an NPM (show NPM1 Antibodies)/MLF1 fusion is the primary molecular abnormality in t(3;5) MDS (show PAFAH1B1 Antibodies) and AML (show RUNX1 Antibodies) with multilineage dysplasia, and that cases with NPM (show NPM1 Antibodies)/MLF1 may be clinically distinct from other MDS (show PAFAH1B1 Antibodies)-associated disease
Ectopically expressed MLF1 could be responsible for the pathological apoptosis in early myelodysplastic syndrome (MDS (show MECOM Antibodies)) patients.
Mlf1 translocates between nucleus and cytoplasm, associates with a novel hnRNP, and influences gene expression
shuttling of MLF1 is critical for the regulation of cell proliferation and a disturbance in the shuttling balance increases the cell's susceptibility to oncogenic transformation
This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
myeloid leukemia factor 1
, myelodysplasia-myeloid leukemia factor 1
, hematopoietic lineage switch 7