Myosin Light Chain Kinase Proteins (MYLK)

MYLK, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. Additionally we are shipping Myosin Light Chain Kinase Antibodies (159) and Myosin Light Chain Kinase Kits (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYLK 4638 Q15746
MYLK 288057  
MYLK 107589  
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Top Myosin Light Chain Kinase Proteins at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg 15 to 18 Days
$704.00
Details
Escherichia coli (E. coli) Human His tag 100 μg 15 to 18 Days
$720.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$340.00
Details
Yeast Wild boar His tag   1 mg 60 to 71 Days
$2,297.17
Details
Yeast Sheep His tag   1 mg 60 to 71 Days
$3,224.83
Details
Insect Cells Human GST tag 5 μg 11 to 12 Days
$516.00
Details
Insect Cells Human GST tag   10 μg 3 to 4 Days
$310.00
Details
Escherichia coli (E. coli) Rat Un-conjugated   1 mg 11 to 18 Days
$1,762.47
Details

MYLK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Rat (Rattus)
Mouse (Murine)

More Proteins for Myosin Light Chain Kinase (MYLK) Interaction Partners

Human Myosin Light Chain Kinase (MYLK) interaction partners

  1. nmMLCK is a potential molecular target to counteract early stages of atherosclerosis, such as endothelial dysfunction, inflammation through its capacity to increase transendothelial migration of monocytes and, most importantly, through the reorganization of VAMP-dependent vesicles associated with the release of IL-6 in modeled obstructive sleep apnea.

  2. Report direct role for hnRNPA1 in MYLK alternative splicing in lung endothelial cells.

  3. a unique domain within the MLCK splice variant MLCK1 directs perijunctional actomyosin ring (PAMR) recruitment.

  4. We identified 2 novel disease-causing MYLK mutations using TAAD gene panel sequencing, 3explaining the cardiovascular phenotype in 0.6% of the cases (n = 358). Both heterozygous point mutations result in a pre-mature termination codon, probably leading tononsense-mediated mRNA decay and, hence, haploinsufficiency

  5. These data further define the aortic phenotype associated with MYLK pathogenic variants. Given minimal aortic enlargement before dissection, an alternative approach to guide the timing of aortic repair is proposed based on the probability of a dissection at a given age

  6. This study found that MYLK gene Ala1491Ser mutation affect the kinase activity and clinically, it presents with vascular aneurysms and dissection.

  7. miR155 directly suppressed the expression of MYLK without affecting the RhoA pathway.

  8. the MAPKspecific inhibitor SB203580 attenuated the inhibitory effects of 4HPR on the migration of HepG2 cells. Moreover, we also observed that 4HPR inhibited the activation and expression of myosin light chain kinase (MLCK) in HepG2 cells.

  9. Recombinant human MLCK was concentration- and time-dependently degraded by recombinant human MMP9 in vitro, and this process was prevented by the MMP9 inhibitor.

  10. High expression of MLCK is correlated with metastatic triple negative breast cancer.

  11. Interaction between kinase domain and regulatory light chain (RLC) substrate is identified in the absence of calmodulin, indicating restored substrate-binding capability due to mechanically induced removal of the auto-inhibitory regulatory region.

  12. loss of MLCK contributes to the migratory properties of epithelial cells resulting from changes in cell-cell and cell-matrix adhesions, and increased epidermal growth factor receptor signaling.

  13. Its phosphorylation and dephosphorylation regulate smooth muscle contraction and relaxation.

  14. Sixty-seven experienced runners competed in a marathon race. The MLCK genotype (C37885A) of these marathoners was determined. CA heterozygotes for MLCK C37885A might present higher exercise-induced muscle damage after a marathon competition than CC counterparts.

  15. three Megacystis microcolon intestinal hypoperistalsis syndrome (MMHS)-affected subjects from two consanguineous families with no variants in the known MMIHS-associated genes.

  16. these Acute respiratory distress syndrome (ARDS)-associated MYLK cytosine-guanine dinucleotides with effect modification by ethnicity and local modified cytosine quantitative trait loci suggest that MYLK epigenetic variation and local genetic background may contribute to health disparities observed in ARDS.

  17. mechanical stress and MYLK single nucleotide polymorphism regulate MYLK alternative splicing.

  18. Rebeccamycin attenuates TNF-alpha-induced disruption of intestinal epithelial barrier integrity by inducing claudin-5 expression and suppressing MLCK production via Chk1 activation.

  19. Data show that alterations in myosin light chain kinase activity, claudin-15 and claudin-2 expression are associated with gluten-induced symptomatology and intestinal permeability changes in diarrhea-predominant irritable bowel syndrome (IBS-D).

  20. PXR regulates the intestinal epithelial barrier during inflammation by modulating cytokine-induced MLCK expression and JNK1/2 activation

Cow (Bovine) Myosin Light Chain Kinase (MYLK) interaction partners

  1. Histamine induces myosin light chain (MLC)phosphorylation via MYLK, suggesting regulatory role for MLC in controlling corneal epithelial permeability.

Rabbit Myosin Light Chain Kinase (MYLK) interaction partners

  1. evaluated the spatial arrangement of the catalytic/regulatory domain, three immunoglobulin-related motifs, one fibronectin-related motif, a repetitive, proline-rich segment, and, at the N-terminus, a unique F-actin-binding domain.

Mouse (Murine) Myosin Light Chain Kinase (MYLK) interaction partners

  1. nmMLCK is a potential molecular target to counteract early stages of atherosclerosis, such as endothelial dysfunction, inflammation through its capacity to increase transendothelial migration of monocytes and, most importantly, through the reorganization of VAMP-dependent vesicles associated with the release of IL-6 in modeled obstructive sleep apnea.

  2. Report direct role for hnRNPA1 in MYLK alternative splicing in lung endothelial cells.

  3. a unique domain within the MLCK splice variant MLCK1 directs perijunctional actomyosin ring (PAMR) recruitment.

  4. telokin may play a role in attenuating constitutive myosin light chain phosphorylation

  5. MLCK is linked to timely blastocyst formation, though it is dispensable for oocyte meiotic maturation

  6. NF-kappaB novel partner within endothelial cells

  7. MLCK regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism.

  8. nmMlck modulates IL-1beta-mediated downregulation of Cldn5 in brain microvascular endothelial cells.

  9. This study provides the first prognostic cancer gene signature derived from a murine model of nmMLCK-associated lung inflammation. Activation of nmMLCK-involved pathways contributes to tumor growth and progression in human cancers.

  10. They also suggest a molecular pathomechanism of hypertrophic cardiomyopathy caused by hVLC-1 mutations.

  11. a prominent effect of the multifunctional microRNA-155 in endothelial cells is modulation of phenotype through alterations in RhoA, myosin light chain kinase expression, and actin cytoskeleton organization

  12. CArG element in intron 15 of the mylk1 gene is necessary for maximal expression of the 130-kDa smMLCK and that the 130-kDa smMLCK isoform is specifically required to regulate smooth muscle contractility

  13. In immune-mediated inflammatory bowel disease, tight junction dysregulation and barrier loss is induced by MLCK, but at advanced stages, barrier loss is MLCK-independent.

  14. Claudin-2 assumes an important role in colorectal inflammation, and furthermore implicates the involvement of MLCK in colon inflammation.

  15. involved in IL-1beta-induced increase in intestinal permeability

  16. These data suggest that myosin light-chain kinase activity may promote morphological and inflammatory responses in the ileum following ethanol exposure and burn injury.

  17. Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle.

  18. Myosin light-chain kinase is necessary for maintaining the membrane stability of inner hair cells.

  19. Deletion of MLCK restored intestinal barrier function in STAT5 knockout mice, and facilitated mucosal wound healing(MLCK)

  20. MLCK is essential for the translocation and association of cortactin and p47phox.

Zebrafish Myosin Light Chain Kinase (MYLK) interaction partners

  1. Conclude that Mlck1a is the subtype of MLCK that contributes to platelet shape change and thrombus formation.

Myosin Light Chain Kinase (MYLK) Protein Profile

Protein Summary

This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.

Gene names and symbols associated with MYLK

  • myosin light chain kinase (MYLK)
  • myosin light chain kinase (Mylk)
  • myosin, light polypeptide kinase (Mylk)
  • myosin, light chain kinase a (mylka)
  • 9530072E15Rik protein
  • A930019C19Rik protein
  • AAT7 protein
  • AW489456 protein
  • fj60a06 protein
  • KRP protein
  • mlck protein
  • MLCK1 protein
  • mlck1a protein
  • MLCK108 protein
  • MLCK210 protein
  • MSTP083 protein
  • mylk protein
  • MYLK1 protein
  • SMMLCK protein
  • wu:fj60a06 protein
  • zmlck1 protein

Protein level used designations for MYLK

kinase-related protein , myosin light chain kinase, smooth muscle , myosin, light polypeptide kinase , smooth muscle myosin light chain kinase , telokin , kinase related protein, telokin , myosin, light chain kinase , MLCK , myosin light chain kinase , myosin light chain kinase, smooth muscle-like , smooth muscle myosin light chain kinase (61-kDa active fragment) , myosin light chain kinase 1 , smooth muscle MLCK

GENE ID SPECIES
4638 Homo sapiens
288057 Rattus norvegicus
338037 Bos taurus
460640 Pan troglodytes
488012 Canis lupus familiaris
715422 Macaca mulatta
100009143 Oryctolagus cuniculus
100481263 Ailuropoda melanoleuca
107589 Mus musculus
396445 Gallus gallus
396848 Sus scrofa
443334 Ovis aries
100714177 Cavia porcellus
569510 Danio rerio
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