Myosin Light Chain Kinase Proteins (MYLK)

MYLK, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. Additionally we are shipping Myosin Light Chain Kinase Antibodies (124) and Myosin Light Chain Kinase Kits (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYLK 4638 Q15746
MYLK 288057  
MYLK 107589  
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Top Myosin Light Chain Kinase Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$704.00
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$720.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$2,297.17
Details
Yeast Sheep His tag   1 mg Log in to see 60 to 71 Days
$3,224.83
Details
Insect Cells Human GST tag 5 μg Log in to see 11 to 12 Days
$515.20
Details
Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$352.75
Details
Insect Cells Human GST tag   10 μg Log in to see 3 to 4 Days
$310.00
Details
Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

MYLK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Rat (Rattus)
Mouse (Murine)

More Proteins for Myosin Light Chain Kinase (MYLK) Interaction Partners

Human Myosin Light Chain Kinase (MYLK) interaction partners

  1. miR155 directly suppressed the expression of MYLK without affecting the RhoA (show RHOA Proteins) pathway.

  2. the MAPKspecific inhibitor SB203580 attenuated the inhibitory effects of 4HPR on the migration of HepG2 cells. Moreover, we also observed that 4HPR inhibited the activation and expression of myosin light chain kinase (MLCK) in HepG2 cells.

  3. Recombinant human MLCK was concentration- and time-dependently degraded by recombinant human MMP9 (show MMP9 Proteins) in vitro, and this process was prevented by the MMP9 (show MMP9 Proteins) inhibitor.

  4. High expression of MLCK is correlated with metastatic triple negative breast cancer.

  5. Interaction between kinase domain and regulatory light chain (RLC) substrate is identified in the absence of calmodulin, indicating restored substrate-binding capability due to mechanically induced removal of the auto-inhibitory regulatory region.

  6. loss of MLCK contributes to the migratory properties of epithelial cells resulting from changes in cell-cell and cell-matrix adhesions, and increased epidermal growth factor receptor (show EGFR Proteins) signaling.

  7. Sixty-seven experienced runners competed in a marathon race. The MLCK genotype (C37885A) of these marathoners was determined. CA heterozygotes for MLCK C37885A might present higher exercise-induced muscle damage after a marathon competition than CC counterparts.

  8. these Acute respiratory distress syndrome (ARDS)-associated MYLK cytosine-guanine dinucleotides with effect modification by ethnicity and local modified cytosine quantitative trait loci suggest that MYLK epigenetic variation and local genetic background may contribute to health disparities observed in ARDS.

  9. mechanical stress and MYLK single nucleotide polymorphism regulate MYLK alternative splicing.

  10. Rebeccamycin attenuates TNF-alpha (show TNF Proteins)-induced disruption of intestinal epithelial barrier integrity by inducing claudin-5 (show CLDN5 Proteins) expression and suppressing MLCK production via Chk1 (show CHEK1 Proteins) activation.

Cow (Bovine) Myosin Light Chain Kinase (MYLK) interaction partners

  1. Histamine induces myosin light chain (MLC)phosphorylation via MYLK, suggesting regulatory role for MLC in controlling corneal epithelial permeability.

Rabbit Myosin Light Chain Kinase (MYLK) interaction partners

  1. evaluated the spatial arrangement of the catalytic/regulatory domain, three immunoglobulin-related motifs, one fibronectin-related motif, a repetitive, proline-rich segment, and, at the N-terminus, a unique F-actin-binding domain.

Mouse (Murine) Myosin Light Chain Kinase (MYLK) interaction partners

  1. telokin may play a role in attenuating constitutive myosin light chain phosphorylation

  2. MLCK is linked to timely blastocyst formation, though it is dispensable for oocyte meiotic maturation

  3. NF-kappaB (show NFKB1 Proteins) novel partner within endothelial cells

  4. MLCK regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism.

  5. nmMlck modulates IL-1beta (show IL1B Proteins)-mediated downregulation of Cldn5 (show CLDN5 Proteins) in brain microvascular endothelial cells.

  6. a prominent effect of the multifunctional microRNA-155 in endothelial cells is modulation of phenotype through alterations in RhoA, myosin light chain kinase expression, and actin cytoskeleton organization

  7. CArG element in intron 15 of the mylk1 gene is necessary for maximal expression of the 130-kDa smMLCK and that the 130-kDa smMLCK isoform is specifically required to regulate smooth muscle contractility

  8. In immune-mediated inflammatory bowel disease, tight junction dysregulation and barrier loss is induced by MLCK, but at advanced stages, barrier loss is MLCK-independent.

  9. Claudin-2 (show CLDN2 Proteins) assumes an important role in colorectal inflammation, and furthermore implicates the involvement of MLCK in colon inflammation.

  10. involved in IL-1beta (show IL1B Proteins)-induced increase in intestinal permeability

Zebrafish Myosin Light Chain Kinase (MYLK) interaction partners

  1. Conclude that Mlck1a is the subtype of MLCK that contributes to platelet shape change and thrombus formation.

Myosin Light Chain Kinase (MYLK) Protein Profile

Protein Summary

This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.

Gene names and symbols associated with MYLK

  • myosin light chain kinase (MYLK)
  • myosin light chain kinase (Mylk)
  • myosin, light polypeptide kinase (Mylk)
  • myosin, light chain kinase a (mylka)
  • 9530072E15Rik protein
  • A930019C19Rik protein
  • AAT7 protein
  • AW489456 protein
  • fj60a06 protein
  • KRP protein
  • mlck protein
  • MLCK1 protein
  • mlck1a protein
  • MLCK108 protein
  • MLCK210 protein
  • MSTP083 protein
  • mylk protein
  • MYLK1 protein
  • SMMLCK protein
  • wu:fj60a06 protein
  • zmlck1 protein

Protein level used designations for MYLK

kinase-related protein , myosin light chain kinase, smooth muscle , myosin, light polypeptide kinase , smooth muscle myosin light chain kinase , telokin , kinase related protein, telokin , myosin, light chain kinase , MLCK , myosin light chain kinase , myosin light chain kinase, smooth muscle-like , smooth muscle myosin light chain kinase (61-kDa active fragment) , myosin light chain kinase 1 , smooth muscle MLCK

GENE ID SPECIES
4638 Homo sapiens
288057 Rattus norvegicus
338037 Bos taurus
460640 Pan troglodytes
488012 Canis lupus familiaris
715422 Macaca mulatta
100009143 Oryctolagus cuniculus
100481263 Ailuropoda melanoleuca
107589 Mus musculus
396445 Gallus gallus
396848 Sus scrofa
443334 Ovis aries
100714177 Cavia porcellus
569510 Danio rerio
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