MYLK Products
(Myosin Light Chain Kinase (MYLK))
Categories
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008].
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Featured MYLK Categories
MYLK Antibodies
High quality antibodies with extensive validation data.
MYLK ELISA Kits
Reliable ELISA kits for a wide range of species.
MYLK Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MYLK Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, ICC, FACS
Validations
- (9)
Cat. No.
ABIN7193606
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7439105
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB
Validations
- (2)
- (4)
Cat. No.
ABIN392495
Quantity
400 μL
Datasheet
Datasheet
Recommended MYLK ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968752
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968751
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957977
Quantity
96 tests
Datasheet
Datasheet
Recommended MYLK Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5569798
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1311785
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1311787
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our MYLK products
: "The Protective Effect of Radix Polygoni Multiflori on Diabetic Encephalopathy via Regulating Myosin Light Chain Kinase Expression." in: Journal of diabetes research, Vol. 2015, pp. 484721, (2016) (PubMed).: "Interferon Stimulated Gene 15 upregulation precedes the development of blood brain barrier disruption and cerebral edema after traumatic brain injury in young mice." in: Journal of neurotrauma, (2015) (PubMed).
: "Pseudomonas fluorescens alters the intestinal barrier function by modulating IL-1? expression through hematopoietic NOD2 signaling." in: Inflammatory bowel diseases, Vol. 21, Issue 3, pp. 543-55, (2015) (PubMed).
: "P2Y6 Receptor-Mediated Microglial Phagocytosis in Radiation-Induced Brain Injury." in: Molecular neurobiology, (2015) (PubMed).
: "Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling." in: The Journal of clinical investigation, Vol. 122, Issue 6, pp. 2239-51, (2012) (PubMed).
: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).
: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, (2001) (PubMed).
: "The RET proto-oncogene in human cancers." in: Oncogene, Vol. 19, Issue 49, pp. 5590-7, (2000) (PubMed).
: "Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: organization, expression, alternative splicing, and polymorphic marker." in: Journal of cellular biochemistry, Vol. 75, Issue 3, pp. 481-91, (2000) (PubMed).
Synonyms and alternative names related to MYLK
myosin light chain kinase (MYLK), myosin light chain kinase (Mylk), myosin, light polypeptide kinase (Mylk), myosin, light chain kinase a (mylka), 9530072E15Rik, A930019C19Rik, AAT7, AW489456, fj60a06, KRP, MLCK, Mlck, mlck, MLCK1, mlck1a, MLCK108, MLCK210, MSTP083, mylk, MYLK1, smMLCK, SMMLCK, wu:fj60a06, zmlck1Protein level used designations for MYLK
- kinase-related protein
- myosin light chain kinase, smooth muscle
- myosin, light polypeptide kinase
- smooth muscle myosin light chain kinase
- telokin
- kinase related protein, telokin
- myosin, light chain kinase
- MLCK
- myosin light chain kinase
- myosin light chain kinase, smooth muscle-like
- smooth muscle myosin light chain kinase (61-kDa active fragment)
- myosin light chain kinase 1
- smooth muscle MLCK
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