NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 1, 7.5kDa Proteins (NDUFA1)

The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. Additionally we are shipping NDUFA1 Antibodies (65) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NDUFA1 54405 O35683
Rat NDUFA1 NDUFA1 363441  
NDUFA1 4694 O15239
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Top NDUFA1 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
Details
Escherichia coli (E. coli) Human GST tag NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 1, 7.5kDa (NDUFA1) (AA 1-70), (full length) protein (GST tag) 1 mg Log in to see 60 to 71 Days
$1,842.50
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$325.44
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Yeast Bonobo His tag   1 mg Log in to see 60 to 71 Days
$2,082.67
Details
Yeast Chinese Hamster His tag   1 mg Log in to see 60 to 71 Days
$2,082.67
Details

NDUFA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 1, 7.5kDa (NDUFA1) Interaction Partners

Mouse (Murine) NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 1, 7.5kDa (NDUFA1) interaction partners

  1. In an X-chromosome linked model for partial Complex I deficiency, Ndufa1 mutant males displayed reduced respiratory exchange and produced less body heat.

  2. Species-specific and mutant MWFE proteins effect on the assembly of a functional mammalian mitochondrial complex I.

Human NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 1, 7.5kDa (NDUFA1) interaction partners

  1. Results from a study on gene expression variability markers in early-stage human embryos shows that NDUF1A is a putative expression variability marker for the 3-day, 8-cell embryo stage.

  2. The gene signature of OPA1, CTSA, NDUFA1, STK10 and PRDX1 was able to identify patients post-implant with a sensitivity of 91% and a specificity of 86% in discrimination between post-implant group and healthy controls.

  3. Fanconi anemia complementation group A mutants show defective respiration through Complex I, diminished ATP production and metabolic sufferance with an increased AMP/ATP ratio.

  4. Heterozygous mutation in the X chromosomal NDUFA1 gene in a girl with complex I deficiency

  5. Mutations in the NDUFA1 gene is linked to a delayed mitochondrial network recovery in OXPHOS disorders.

  6. Species-specific and mutant MWFE proteins effect on the assembly of a functional mammalian mitochondrial complex I.

  7. A family-based association study finds that the NDUFA1 gene is unlikely to harbor a major visual loss susceptibility locus for Leber hereditary optic neuropathy.

  8. Oxidative stress and partial deficiencies of mitochondrial complex I are key factors in the pathogenesis of Parkinson's disease. (REVIEW)

  9. Suppression of NDUFA1 expression could represent a key pathogenic mechanism in the development of basal cell carcinoma

  10. Two novel p.Gly8Arg and p.Arg37Ser hemizygous mutations in NDUFA1 were identified in two unrelated male patients presenting with Leigh's syndrome and with myoclonic epilepsy and developmental delay.

  11. hypothesize that the novel G32R mutation in NDUFA1 is causing complex I deficiency either by itself or in synergy with additional mtDNA variants

Cow (Bovine) NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 1, 7.5kDa (NDUFA1) interaction partners

  1. subunit MWFE is required for assembly into complex I of seven hydrophobic subunits encoded in the mitochondrial genome

NDUFA1 Protein Profile

Protein Summary

The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the 'hydrophobic protein' (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function.

Gene names and symbols associated with NDUFA1

  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (Ndufa1)
  • NADH:ubiquinone oxidoreductase subunit A1 (Ndufa1)
  • NADH:ubiquinone oxidoreductase subunit A1 (NDUFA1)
  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa (NDUFA1)
  • 1810049F12Rik protein
  • CI-MWFE protein
  • MWFE protein
  • RGD1560955 protein
  • ZNF183 protein

Protein level used designations for NDUFA1

CI-MWFE , NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (7.5kD, MWFE) , NADH dehydrogenase 1 alpha subcomplex, 1 , NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 , NADH ubiquinone oxidoreductase subunit MWFE , NADH-ubiquinone oxidoreductase MWFE subunit , complex I-MWFE , Complex I-MWFE , NADH ubiquinone oxidoreductase NDUFA1 , NADH oxidoreductase subunit MWFE , NADH:ubiquinone oxidoreductase (complex 1) , complex I MWFE subunit , type I dehydrogenase

GENE ID SPECIES
54405 Mus musculus
363441 Rattus norvegicus
100689328 Cricetulus griseus
4694 Homo sapiens
481033 Canis lupus familiaris
327673 Bos taurus
100983914 Pan paniscus
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