anti-NDRG Family Member 2 (NDRG2) Antibodies

NDRG2 is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. Additionally we are shipping NDRG2 Proteins (24) and NDRG2 Kits (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NDRG2 29811 Q9QYG0
NDRG2 57447 Q9UN36
NDRG2 171114 Q8VBU2
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Top anti-NDRG2 Antibodies at antibodies-online.com

Showing 10 out of 109 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Mouse Un-conjugated ELISA, WB NDRG2 monoclonal antibody (M03), clone 6A5 Western Blot analysis of NDRG2 expression in HeLa Detection limit for recombinant GST tagged NDRG2 is approximately 0.03ng/ml as a capture antibody. 100 μg 11 to 12 Days
$440.00
Details
Cow Rabbit Un-conjugated IHC, WB Host:  Rabbit  Target Name:  NDRG2  Sample Tissue:  Mouse Liver  Antibody Dilution:  1ug/ml 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Ndrg2 Antibody   Titration: 1.0 ug/ml   Positive Control: Mouse Kidney 100 μL 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated IHC (p), WB Anti- NDRG2 Picoband antibody, IHC(P) IHC(P): Mouse Brain Tissue 100 μg 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated WB Anti- NDRG2 antibody, Western blotting All lanes: Anti NDRG2  at 0.5ug/ml Lane 1: SMMC Whole Cell Lysate at 40ug Lane 2: PANC Whole Cell Lysate at 40ug Predicted bind size: 41KD Observed bind size: 41KD 100 μg 4 to 6 Days
$240.00
Details
Human Goat Un-conjugated ELISA, IHC, WB ABIN625831 (0.1µg/ml) staining of Human Temporal Cortex lysate (35µg protein in RIPA buffer). Detected by chemiluminescence. ABIN625831 (0.3µg/ml) staining of Mouse (A) and Rat (B) Brain lysates (35µg protein in RIPA buffer). Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Cow Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of NDRG2 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of NDRG2 expression in HeLa (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of NDRG2 Antibody (N-term) in CEM cell line lysates (35ug/lane). This demonstrates the NDRG2 antibody detected the NDRG2 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg 2 to 3 Days
$515.63
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-NDRG2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other form ... 100 μL 11 to 14 Days
$727.83
Details

Top referenced anti-NDRG2 Antibodies

  1. Human Monoclonal NDRG2 Primary Antibody for ELISA, WB - ABIN566107 : Shen, Zhao, Wang, Ji, Liu, Liu, Che, Lin, Li, Zhang, Yao: Immunohistochemical detection of Ndrg2 in the mouse nervous system. in Neuroreport 2008 (PubMed)
    Show all 16 Pubmed References

  2. Human Polyclonal NDRG2 Primary Antibody for ICC, IF - ABIN4338340 : Tepel, Roerig, Wolter, Gutmann, Perry, Reifenberger, Riemenschneider: Frequent promoter hypermethylation and transcriptional downregulation of the NDRG2 gene at 14q11.2 in primary glioblastoma. in International journal of cancer 2008 (PubMed)
    Show all 5 Pubmed References

  3. Human Polyclonal NDRG2 Primary Antibody for ELISA, WB - ABIN528174 : Araya-Callís, Hiemke, Abumaria, Flugge: Chronic psychosocial stress and citalopram modulate the expression of the glial proteins GFAP and NDRG2 in the hippocampus. in Psychopharmacology 2012 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal NDRG2 Primary Antibody for WB - ABIN528175 : Wang, Zhong, Li, Peng, Kinden, Liang, Li, Shi, Liu, Wang, Xiong: Electroacupuncture attenuates reference memory impairment associated with astrocytic NDRG2 suppression in APP/PS1 transgenic mice. in Molecular neurobiology 2014 (PubMed)

  5. Human Polyclonal NDRG2 Primary Antibody for ELISA, WB - ABIN4338339 : Shi, Li, Li, Chen, Wang, Xu, Zhang, Jin, Zhang, Zhao, Song, Feng, Feng, Shen, Yao, Zhao: Expression of NDRG2 in esophageal squamous cell carcinoma. in Cancer science 2010 (PubMed)

  6. Mouse (Murine) Polyclonal NDRG2 Primary Antibody for IHC (p), WB - ABIN3043261 : Sun, Shen, Sun, Tong, Sun, Han, Yang, Zhang, Cao, Yao, Wang: Variation of NDRG2 and c-Myc expression in rat heart during the acute stage of ischemia/reperfusion injury. in Histochemistry and cell biology 2011 (PubMed)

More Antibodies against NDRG2 Interaction Partners

Mouse (Murine) NDRG Family Member 2 (NDRG2) interaction partners

  1. Study identified FLNa as a substrate of Ndr2 in vitro and demonstrated that Ndr2 phosphorylates FLNa at serine 2152 (S2152) upon TCR-triggering in vivo. Ndr2-dependent phosphorylation of FLNa at S2152 releases the binding of this molecule from the inactive conformation of LFA-1, thus allowing the TCR-mediated association of Talin and Kindlin-3 to the cytoplasmatic domain of CD18.

  2. Ndr2 is important regulator of the retinal interneurons.

  3. NF-kappaB participated in the hepatocellular carcinoma suppressor function of Ndrg2-deficient macrophages.

  4. N-Myc downstream-regulated gene-2 (NDRG2) is a newly identified differentiation- and stress-associated gene that is highly expressed in the heart, muscle, kidney, and brain.

  5. These findings suggest that NDRG2 plays a key role in the pathology of experimental autoimmune encephalomyelitis by modulating glutamate metabolism

  6. results indicate that NDRG2 deficiency leads to Attention-deficit/hyperactivity disorder (ADHD) phenotypes and that impaired astroglial glutamate clearance, a mechanism distinct from the well-established dopamine deficit hypothesis for ADHD, underlies the resultant behavioral abnormalities.

  7. Immunohistological analysis showed that the expression of NDRG2 increases dominantly in astrocytes following permanent middle cerebral artery occlusion (MCAO). Genetic deletion of Ndrg2 exhibited enhanced levels of infarct volume and accumulation of immune cells into the ipsilateral brain hemisphere following ischemia. Expression of matrix metalloproteinases (MMPs) after MCAO markedly increased in Ndrg2(-/-) mice.

  8. Increased level of NDRG2 in cortex or hippocampus may be a potential risk for Alzheimer's disease. NDRG2 increased Abeta1-42 might be related to the changes of BEAC1 and GGA3. It might also affect CDK5 and tau overphosphorylation. NDRG2 interacting with STAT3 and modulating Fas/Fasl signaling pathway plays important roles in cell death.

  9. These findings provide insight into the role of NDRG2 in ischemic-hypoxic injury and provide potential targets for future clinical therapies for stroke.

  10. NDRG2 is a novel ERS-responsive protein and acts as PERK co-factor to facilitate PERK branch, thereby contributing to ERS-induced apoptosis.

  11. Our results show how NDRG2 expression serves as a critical determinant of the invasive and metastatic capacity of oral squamous cell carcinoma (OSCC)

  12. Using double knockout of NDR1 and 2 shows that NDRs acted downstream of MST1 to mediate the egress of mature thymocytes from the thymus, as well as the interstitial migration of naive T cells within popliteal lymph nodes.

  13. The expression level of NDRG2 has a causal influence on mood-related phenotypes.

  14. Ndr1/2-double null embryos show defects in somitogenesis and cardiac looping, which reveals their essential functions and shows that the NDR kinases are critically required during the early phase of organogenesis

  15. Taken together, our results suggest that the expression of NDRG2 potentially inhibits osteoclast differentiation and plays a role in modulating the signal transduction pathway responsible for osteoclastogenesis.

  16. NDRG2 is associated with decidualization during early pregnancy.

  17. NDRG2 accumulated in skeletal muscle and myoblasts in the absence of TRIM32. NDRG2 overexpression in myoblasts led to reduced cell proliferation and delayed cell cycle withdrawal during differentiation.

  18. Electroacupuncture administration can alleviate reference memory deficits and suppress N-myc downstream-regulated gene 2 upregulation in an AD transgenic mouse model

  19. Rassf5 and Ndr1 or Ndr2 kinases regulate neuronal polarity through Par3 phosphorylation.

  20. Ndrg2 plays a key role in reactive astrogliosis after cortical stab injury through a mechanism involving the positive regulation of IL-6/STAT3 signaling

Human NDRG Family Member 2 (NDRG2) interaction partners

  1. Study identified FLNa as a substrate of NDR2 in vitro and demonstrated that NDR2 phosphorylates FLNa at serine 2152 (S2152) upon TCR-triggering in vivo. NDR2-dependent phosphorylation of FLNa at S2152 releases the binding of this molecule from the inactive conformation of LFA-1, thus allowing the TCR-mediated association of Talin and Kindlin-3 to the cytoplasmatic domain of CD18.

  2. Low NDRG2 expression is associated with proliferation, migration, invasion and epithelial-mesenchymal transition of esophageal cancer.

  3. Supporting the biological significance of the reciprocal relationship between NDRG2 and Skp2, an NDRG2low/Skp2high gene expression signature correlates with poor colorectal cancer (CRC) patient outcome and could be considered as a diagnostic marker of CRCs.

  4. We observed the knockdown of NDRG2 with miR-28-5p and miR-650 inhibitors inducing CLL cell apoptosis, yet found no increased apoptosis rates in patients with p53 aberrations following transfection with the above miRNAs inhibitors.

  5. NDRG2 knockdown promotes renal fibrosis through its effect on the protein and mRNA expression of epithelial-mesenchymal transition markers.

  6. Data show that Sentrin/SUMO specific protease (SENP2) interacts with N-myc downstream regulated gene 2 (NDRG2) and mediates the de-SUMOylation process of NDRG2.

  7. Down-regulation of NDRG2 promotes cancer cell proliferation and neoplasm invasion through regulation by microRNA-454.

  8. Increased level of NDRG2 in cortex or hippocampus may be a potential risk for Alzheimer's disease. NDRG2 increased Abeta1-42 might be related to the changes of BEAC1 and GGA3. It might also affect CDK5 and tau overphosphorylation. NDRG2 interacting with STAT3 and modulating Fas/Fasl signaling pathway plays important roles in cell death.

  9. Lower expression of KLF4 and NDRG2 in colorectal cancer patients was correlated with poor overall survival. Thus, KLF4 inhibited the proliferation of colorectal cancer cells dependent on NDRG2 signaling, which provides a novel strategy for therapy and early diagnosis of colorectal cancer.

  10. NDRG2 could be a potential independent diagnostic biomarker for bladder cancer.

  11. The different NDRG2 promoter methylation and expression levels in pituitary adenoma samples showed tumor heterogeneity and indicates a potential role of this gene in pituitary adenoma pathogenesis.

  12. NDRG2 expression decreased in adriamycin resistance breast cancer cells. NDRG2 can promote adriamycin sensitivity by inhibiting proliferation, enhancing cellular damage responses, and promoting apoptosis in a p53-dependent manner.

  13. Authors investigate the clinical and pathological role of NDRG2 in human malignant tumors. The absence of NDRG2 expression is associated with oncogenic properties through the loss of its role as a tumor suppressor; NDRG2 overexpression inhibits proliferation, adhesion, and invasion, whereas its expression is low or undetectable in various cancers. [Review]

  14. These findings indicate that SUMOylation of NDRG2 is necessary for its tumor suppressor function in lung adenocarcinoma and that RNF4 increases the efficiency of this process.

  15. NDRG2 is a novel ERS-responsive protein and acts as PERK co-factor to facilitate PERK branch, thereby contributing to ERS-induced apoptosis.

  16. Our results show how NDRG2 expression serves as a critical determinant of the invasive and metastatic capacity of oral squamous cell carcinoma (OSCC)

  17. putative tumor suppressive function of NDRG2 may be confined to luminal- and basal B-type breast cancers

  18. Overexpression of NDRG2 can inhibit the proliferation.

  19. present results suggest that hypermethylation in promoter around exon 2 is functioning as essential factors of NDRG2 silencing in gastrointestinal cancers

  20. NDRG2 overexpression significantly reduced hepatoma cell proliferation and enhanced cell apoptosis under glucose limitation. Moreover, NDRG2 overexpression aggravated energy imbalance and oxidative stress by decreasing the intracellular ATP and NADPH generation and increasing ROS levels.

NDRG2 Antigen Profile

Protein Summary

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with NDRG2

  • NDRG family member 2 (ndrg2) antibody
  • NDRG family member 2 (NDRG2) antibody
  • N-myc downstream regulated gene 2 (Ndrg2) antibody
  • NDRG family member 2 S homeolog (ndrg2.S) antibody
  • NDRG family member 2 (Ndrg2) antibody
  • AI182517 antibody
  • AU040374 antibody
  • im:6909381 antibody
  • Ndr2 antibody
  • NDRG2 antibody
  • si:dkey-88n24.1 antibody
  • SYLD antibody
  • zgc:101847 antibody

Protein level used designations for NDRG2

protein NDRG2 , NDRG family member 2 , N-myc downstream-regulated gene 2 , N-myc downstream regulated 2 , N-myc downstream-regulated gene 2 protein , protein Ndr2 , N-myc downstream regulator 2 , NDR1-related protein NDR2 , cytoplasmic protein Ndr1 , syld709613 protein , N-myc downstream regulated gene 2 , NDRG1-related protein , antidepressant-related protein ADRG123 , N-Myc downstream regulated gene 2

GENE ID SPECIES
493281 Xenopus (Silurana) tropicalis
706990 Macaca mulatta
100351595 Oryctolagus cuniculus
29811 Mus musculus
494050 Danio rerio
380081 Xenopus laevis
57447 Homo sapiens
609390 Canis lupus familiaris
515063 Bos taurus
171114 Rattus norvegicus
100174656 Pongo abelii
100499579 Pan troglodytes
780431 Sus scrofa
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