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NELL1 encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats.
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Nell-1-haploinsufficient mice (show WNT2 Proteins)have normal s (show CTNNB1 Proteins)keletal development but undergo age-related osteoporosis, characterized by a reduction in osteoblast:osteoclast ratio and increased bone fragility.
These results suggest that an oligomerization-induced conformational change in the C-terminal region of NELL1 is important for the efficient mediation of cell adhesion and spreading by NELL1.
Nell-1 might play a role in ameloblast and odontoblast differentiation, secretion and mineralization of the extracellular enamel matrix, molar crown morphogenesis, as well as root formation during the entire development period.
NELL-1 protein promotes cell adhesion in ST2 cells.
The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin alpha3beta1
data suggest Nell-1 is important growth factor for regulation of osteochondral differentiation regulating both Runx2 (show RUNX2 Proteins) and Sox9 (show SOX9 Proteins) expression in calvarium. Nell-1 is required for normal craniofacial membranous and endochondral skeletal development.
These studies suggest that Nell-1 is a potent anti-adipogenic agent. Moreover, Nell-1 signaling may inhibit adipogenic differentiation via a Hedgehog (show SHH Proteins) dependent mechanism.
Nfatc2 (show NFAT1 Proteins) likely plays an important role in Nell-1-mediated osteochondral differentiation in vitro and in vivo.
Nell-1 supports continued osteoblastic differentiation and function in osteoblastic lineage cells during calvarial development. Nell-1 is a key functional, downstream mediator of Runx2 (show RUNX2 Proteins) osteogenic activity.
A recessive, neonatal-lethal point mutation in the Nell1 gene causes cranial and skeletal defects.
Results demonstrate that NELL1 is differentially expressed in fusion-positive alveolar rhabdomyosarcoma (ARMS) and in embryonal rhabdomyosarcoma (ERMS) samples, and they show that this transcriptional difference partially depends on genomic DNA methylation (show HELLS Proteins). The study also found that high NELL1 levels are correlated with negative RMS prognostic factors and with poor tumor outcomes.
lipoaspirate-derived hPSCs present a novel and abundant cell source of MSCs for cartilage regeneration, and the combinatorial application of NELL-1, TGF-beta3 (show TGFB3 Proteins), and BMP-6 (show BMP6 Proteins) with hPSCs may remarkably enhance and accelerate cartilage repair.
establish the feasibility of combining NELL-1 with BMP2 (show BMP2 Proteins) to improve clinical bone regeneration and provide mechanistic insight into canonical Wnt (show WNT2 Proteins) pathway activity during NELL-1 and BMP2 (show BMP2 Proteins) osteogenesis
Data suggest that TSPN (N-terminal thrombospondin-1-like (show THBS1 Proteins)) domain of NELL1 exhibits major heparin-binding sites which may be involved in interaction of NELL1 with cell surface heparan sulfate proteoglycans.
NELL-1 signaling activates Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
We also detected lower relative expression of Nell-1 by real-time PCR. Furthermore, immunohistochemical analyses revealed that Nell-1 staining was less intense in cancer tissue relative to normal tissue and that the tumor cells had spread to the muscle
CpG islands in the NELL1 and NELL2 promoters are hypermethylated in renal cell carcinoma.NELL1 and NELL2 protein expression is downregulated in clear cell renal carcinoma.
NELL-1 demonstrates diffuse and reliable expression in benign but not malignant bone-forming skeletal tumors
NELL1 overexpression greatly enhanced the osteogenic differentiation and mineral synthesis of iPSC-MSCs on RGD-grafted CPC scaffold for the first time.
Two single-nucleotide polymorphisms of the NELL1 gene may represent a novel mechanism underlying hydrochlorothiazide-induced adverse metabolic effects (meta-analysis).
This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Two transcript variants encoding different isoforms have been found for this gene.
NEL-like protein 1
, protein kinase C-binding protein NELL1
, NELL-1 protein short isoform
, nel-related protein 1
, neural epidermal growth factor-like 1