NEL-Like 1 (Chicken) Proteins (NELL1)

NELL1 encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. Additionally we are shipping NEL-Like 1 (Chicken) Antibodies (38) and NEL-Like 1 (Chicken) Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NELL1 338352 Q2VWQ2
NELL1 4745 Q92832
NELL1 81733 Q62919
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Top NEL-Like 1 (Chicken) Proteins at

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Human Cells Human His tag   50 μg Log in to see 4 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Human Cells Human His tag   10 μg Log in to see 15 to 16 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
HEK-293 Cells Human His tag   10 μg Log in to see 8 to 11 Days

NELL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
Rat (Rattus)

More Proteins for NEL-Like 1 (Chicken) (NELL1) Interaction Partners

Mouse (Murine) NEL-Like 1 (Chicken) (NELL1) interaction partners

  1. Nell-1-haploinsufficient mice (show WNT2 Proteins)have normal s (show CTNNB1 Proteins)keletal development but undergo age-related osteoporosis, characterized by a reduction in osteoblast:osteoclast ratio and increased bone fragility.

  2. These results suggest that an oligomerization-induced conformational change in the C-terminal region of NELL1 is important for the efficient mediation of cell adhesion and spreading by NELL1.

  3. Nell-1 might play a role in ameloblast and odontoblast differentiation, secretion and mineralization of the extracellular enamel matrix, molar crown morphogenesis, as well as root formation during the entire development period.

  4. NELL-1 protein promotes cell adhesion in ST2 cells.

  5. The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin alpha3beta1

  6. data suggest Nell-1 is important growth factor for regulation of osteochondral differentiation regulating both Runx2 (show RUNX2 Proteins) and Sox9 (show SOX9 Proteins) expression in calvarium. Nell-1 is required for normal craniofacial membranous and endochondral skeletal development.

  7. These studies suggest that Nell-1 is a potent anti-adipogenic agent. Moreover, Nell-1 signaling may inhibit adipogenic differentiation via a Hedgehog (show SHH Proteins) dependent mechanism.

  8. Nfatc2 (show NFAT1 Proteins) likely plays an important role in Nell-1-mediated osteochondral differentiation in vitro and in vivo.

  9. Nell-1 supports continued osteoblastic differentiation and function in osteoblastic lineage cells during calvarial development. Nell-1 is a key functional, downstream mediator of Runx2 (show RUNX2 Proteins) osteogenic activity.

  10. A recessive, neonatal-lethal point mutation in the Nell1 gene causes cranial and skeletal defects.

Human NEL-Like 1 (Chicken) (NELL1) interaction partners

  1. This work indicates that NELL-1, HMGB1 (show HMGB1 Proteins), and CCN2 (show CTGF Proteins) might enhance bone defect healing via the recruitment of endogenous cells and induction of vascularization and act via different processes than BMP2 (show BMP2 Proteins).

  2. NELL1 variant is associated with tobacco- and HPV-mediated oral oncogenesis.

  3. Results demonstrate that NELL1 is differentially expressed in fusion-positive alveolar rhabdomyosarcoma (ARMS) and in embryonal rhabdomyosarcoma (ERMS) samples, and they show that this transcriptional difference partially depends on genomic DNA methylation (show HELLS Proteins). The study also found that high NELL1 levels are correlated with negative RMS prognostic factors and with poor tumor outcomes.

  4. lipoaspirate-derived hPSCs present a novel and abundant cell source of MSCs for cartilage regeneration, and the combinatorial application of NELL-1, TGF-beta3 (show TGFB3 Proteins), and BMP-6 (show BMP6 Proteins) with hPSCs may remarkably enhance and accelerate cartilage repair.

  5. establish the feasibility of combining NELL-1 with BMP2 (show BMP2 Proteins) to improve clinical bone regeneration and provide mechanistic insight into canonical Wnt (show WNT2 Proteins) pathway activity during NELL-1 and BMP2 (show BMP2 Proteins) osteogenesis

  6. Data suggest that TSPN (N-terminal thrombospondin-1-like (show THBS1 Proteins)) domain of NELL1 exhibits major heparin-binding sites which may be involved in interaction of NELL1 with cell surface heparan sulfate proteoglycans.

  7. NELL-1 signaling activates Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  8. We also detected lower relative expression of Nell-1 by real-time PCR. Furthermore, immunohistochemical analyses revealed that Nell-1 staining was less intense in cancer tissue relative to normal tissue and that the tumor cells had spread to the muscle

  9. CpG islands in the NELL1 and NELL2 promoters are hypermethylated in renal cell carcinoma.NELL1 and NELL2 protein expression is downregulated in clear cell renal carcinoma.

  10. NELL-1 demonstrates diffuse and reliable expression in benign but not malignant bone-forming skeletal tumors

NEL-Like 1 (Chicken) (NELL1) Protein Profile

Protein Summary

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NEL-Like 1 (Chicken) Proteins (NELL1)

  • NEL-like 1 (Nell1)
  • neural EGFL like 1 (NELL1)
  • neural EGFL like 1 (Nell1)
  • B230343H07Rik protein
  • IDH3GL protein
  • l7R6 protein
  • NRP1 protein

Protein level used designations for NEL-Like 1 (Chicken) Proteins (NELL1)

NEL-like protein 1 , protein kinase C-binding protein NELL1 , NELL-1 protein short isoform , nel-related protein 1 , neural epidermal growth factor-like 1

338352 Mus musculus
4745 Homo sapiens
81733 Rattus norvegicus
100336918 Bos taurus
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