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The protein encoded by NEK6 is a kinase required for progression through the metaphase portion of mitosis. Additionally we are shipping NEK6 Antibodies (73) and many more products for this protein.
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NEK6 is overexpressed in various human cancer tissues, and ectopic expression of NEK6 increases tumor promoter-induced transformation of JB6 Cl41 mouse epidermal cells.
During early embryogenesis nek6 is highly expressed in primary giant trophoblast cells. Later in embryogenesis, nek6 is found in ventricular and sub-ventricular regions.
NEK6 (show NEK5 Proteins) forms heterodimers with NEK4 and NEK5 to regulate cortical microtubule organization possibly through the phosphorylation of beta-tubulins.
cis (show CISH Proteins)-regulatory circuits that lead to overexpression of NEK6, a mitosis-associated kinase, in human B cell lymphoma, were analyzed.
High NEK6 expression is associated with Cluster Amplified Centrosomes in cancer.
Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 to properly coordinate cytokinesis.
our studies establish NEK6 signaling as a central mechanism mediating castration-resistant prostate cancer
overexpression of PAK1 (show PAK1 Proteins), NEK6, AURKA (show AURKA Proteins), and AURKB (show AURKB Proteins) genes in patients with Colorectal adenomatous polyp and colorectal cancer in the Turkish population.
We found that NEK6-mediated phosphorylation of TPP1 (show TPP1 Proteins) Ser255 in G2/M phase regulates the association between telomerase activity and TPP1 (show TPP1 Proteins). Furthermore, we found evidence that POT1 (show POT1 Proteins) negatively regulates TPP1 (show TPP1 Proteins) phosphorylation because the level of Ser255 phosphorylation was elevated when telomeres were elongated by a POT1 (show POT1 Proteins) mutant lacking its OB-fold domains
Overexpression of AURKA (show AURKA Proteins) and NEK6 genes was significantly more pronounced in Ulcerative colitis patients with more extensive colon involvement
NEK6 suppresses the cell growth arrest induced by TGFbeta (show TGFB1 Proteins). Mechanically, NEK6 blocks nuclear translocation of Smad4 (show SMAD4 Proteins), which is essential for TGFbeta (show TGFB1 Proteins) function.
Nek6 is also a critical signaling molecule that helps prevent cardiac hypertrophy and inhibits the Akt (show AKT1 Proteins) signaling pathway.
Nek6 facilitates association of Hsp72 (show HSPA1A Proteins) with the mitotic spindle, where it promotes stable K-fiber assembly through recruitment of the ch-TOG-TACC3 (show TACC3 Proteins) complex.
The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene.
NIMA-related expressed kinase 6
, never in mitosis A-related kinase 6
, nimA-related protein kinase 6
, serine/threonine-protein kinase Nek6
, putative serine-threonine protein kinase
, NIMA (never in mitosis gene a)-related kinase 6
, protein kinase SID6-1512
, NIMA (never in mitosis gene a)-related expressed kinase 6