NK2 Homeobox 3 Proteins (NKX2-3)

NKX2-3 encodes a homeodomain-containing transcription factor. Additionally we are shipping NK2 Homeobox 3 Antibodies (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NKX2-3 159296 Q8TAU0
NKX2-3 18089 P97334
Rat NKX2-3 NKX2-3 309389  
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Top NK2 Homeobox 3 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

NKX2-3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for NK2 Homeobox 3 (NKX2-3) Interaction Partners

Human NK2 Homeobox 3 (NKX2-3) interaction partners

  1. NKX2-3 is a key mediator for maintaining myofibroblast characteristics, and our results show that colorectal myofibroblasts, as defined by the expression of AOC3 (show AOC2 Proteins), NKX2-3, and other markers, are a distinctly different cell type from TGFbeta (show TGFB1 Proteins)-activated fibroblasts

  2. The persons with a NKX2-3 G or T allele may have a moderately increased risk of CD.

  3. NKX2-3 may play different roles in ulcerative colitis and Crohn's disease pathogenesis by differential regulation of EGR1 (show EGR1 Proteins).

  4. A positive correlation was observed between mRNA expression of PTPN2 and NKX2-3 in B cells and in intestinal tissues from both Crohn's disease and ulcerative colitis patients.

  5. The binding of NFAT1 to the NKX2-3 promoter region with rs1190140 was confirmed by chromatin immunoprecipitation assay.

  6. the risk haplotype of NKX2.3 confers susceptibility to UC through increasing expression of NKX2.3 mRNA in the colonic mucosa.

  7. NKX2-3 may play an important role in inflammatory bowel disease pathogenesis by regulating endothelin-1 (show EDN1 Proteins) and VEGF (show VEGFA Proteins) signaling in human intestinal microvascular endothelial cells.

  8. Data suggest that NKX2-3 and IRGM (show IRGM Proteins) are susceptibility loci for inflammatory bowel disease in Eastern European patients.

  9. Nkx2-3 may contribute to the pathogenesis of inflammatory bowel disease-associated colorectal cancer and sporadic colorectal cancer by regulating the Wnt (show WNT2 Proteins) signaling pathway.

  10. a decrease in Nkx2-3 gene expression level can profoundly alter the expression of genes and cellular functions relevant to the pathogenesis and progression of inflammatory bowel disease, such as EDN1 (show EDN1 Proteins).

Mouse (Murine) NK2 Homeobox 3 (NKX2-3) interaction partners

  1. Nkx2-3 deficiency reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches.

  2. the organ-specific patterning of splenic vasculature is critically regulated by Nkx2-3, thereby profoundly affecting the lymphocyte homing mechanism and blood filtering capacity of the spleen in a tissue-specific manner.

  3. The splenic vascular defects in Nkx2-3 deficiency include the generation of LYVE-1 (show LYVE1 Proteins)(+) cysts, comprised of endothelial cells without being committed along the LEC lineage.

  4. NKX2.3 has a role in mouse pharyngeal organogenesis

  5. Data indicate a substantial role for Nkx2-3 in the correct association of lymphocytes and splenic stromal elements that is independent of chemokine (show CCL1 Proteins) expression.

  6. Phenotypic heterogeneity among different vascular elements within distinct anatomical regions of the spleen differentially depends on developmental factors such as lymphotoxin (show LTB Proteins) signaling or Nkx2.3, whereas the marginal sinus is controlled by both pathways.

  7. Formation of various white pulp fibroblast subsets is differentially affected by the presence of Nkx2.3 activity, possibly also influencing their role in various immune functions linked with complement activation and deposition.

NK2 Homeobox 3 (NKX2-3) Protein Profile

Protein Summary

This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.

Gene names and symbols associated with NK2 Homeobox 3 Proteins (NKX2-3)

  • NK2 homeobox 3 (NKX2-3)
  • NK2 homeobox 3 (Nkx2-3)
  • NK2 transcription factor related, locus 3 (NKX2-3)
  • CNKX-2.3 protein
  • CSX3 protein
  • NK2.3 protein
  • Nkx-2.3 protein
  • Nkx2.3 protein
  • NKX2C protein
  • NKX4-3 protein
  • tinman protein

Protein level used designations for NK2 Homeobox 3 Proteins (NKX2-3)

NK2 transcription factor related, locus 3 , homeobox protein NK-2 homolog C , homeobox protein Nkx-2.3 , Drosophila NK2 transcription factor related, locus 3 , homeobox protein NK-2 homolog 3 , nkx2-C

159296 Homo sapiens
539451 Bos taurus
18089 Mus musculus
309389 Rattus norvegicus
395888 Gallus gallus
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